Misagh Naderi, PhD

New diffractive camera hides images from view: https://lnkd.in/g2z4hUUY IOP Publishing UCLA Henry Samueli School of Engineering and Applied Science California NanoSystems Institute at UCLA ECE Department #DiffractiveProcessors

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Oregon State University researchers have discovered compounds that convert a #protein known for protecting #cancer cells into a #tumor killer. Scientists say their findings, several years in the making, open the door to promising therapies for #breastcancer and other malignancies whose cells rely on the Bcl-2 protein to evade treatment and develop drug resistance. https://lnkd.in/euUU4j-m "The holy grail in cancer research is finding a molecular target that plays a major, essential role in cancer cell growth that you can go after without causing side effects—that is, without affecting regular cells," said Siva Kolluri, professor of environmental and molecular toxicology in the College of Agricultural Sciences. "Multiple pathways control a normal cell to be normal, and cancer cells hijack one of those pathways that control the rate of proliferation and/or death." https://lnkd.in/euUU4j-m Many types of cells are recycled, Kolluri said, through a programmed cell death process called #apoptosis. Cancer cells, however, neutralize pathways that ordinarily kill cells, allowing these cells to grow out of control and in many cases metastasize, or spread, to other parts of the body. Bcl-2 is an anti-apoptosis protein produced in higher levels by some cancer cells and has been used as a target by many drug researchers, Kolluri said. Inhibiting Bcl-2 has been successful in treating certain blood cancers, but not for solid cancers such as breast cancers. "Cancer cells are so smart, they figure out ways to survive," Kolluri said. "Many therapies do work for a while. But it's like making a car stop, only to have the car move again. Here we're completely taking the wheels off the car. We used the same Bcl-2 pathway but fundamentally made a new discovery: changing how this protein functions so it starts killing cancer cells." The research led by Kolluri and Christiane Löhr, professor of anatomic pathology in the Carlson College of Veterinary Medicine, involved studying triple-negative breast cancer in cell cultures and mouse models. More information: Prasad R. Kopparapu et al, Identification and Characterization of a Small Molecule Bcl-2 Functional Converter, Cancer Research Communications (2024). https://lnkd.in/eretxAZF

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Weekly digest breakthroughs in cancer treatment, chemistry, and more by The Babak Lab https://lnkd.in/deJEF24c Maria (Masha) Babak, PhD FDA Berkeley Lab Vanessa Barrs #Cancer #CancerTreatment #FDA #CancerEducation #ScientificBreakthroughs #OncoDaily #Oncology

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Excellent synthesis of the current state of gene therapy 🤓🧬

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Dr. shahad alsaiari recently published her article, "CRISPR–Cas9 Delivery Strategies for the Modulation of Immune and Non-Immune Cells," in Nature Reviews Materials! Learn more about her publication on our website! #Bioscience #Nanotechnology #WomenInSTEM

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🧪 University of California, Berkeley Professor James Olzmann’s lab is uncovering how cells regulate lipids and the surprising ways these processes impact health. Olzmann’s team uses a combination of systems biology, chemical biology, and cutting-edge techniques like #CRISPR-based genetic screens to make groundbreaking discoveries—like how ferroptosis, a recently discovered form of cell death, could hold new keys to cancer therapies. Olzmann’s passion for discovery extends to mentoring graduate students, calling them “real innovators” who tackle big questions with creativity. As part of the new division of Molecular Therapeutics, his work is shaping the future of drug discovery and disease research.💡 Learn more ➡️ https://bit.ly/49wsZDX

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A paper from our group was just published on PLOSONE with Dr. Katherine Swanson (now at Cal Poly) as first author and in collaboration with Dr. David Hendrix, Dr. Duo Jiang, and Dr. Michelle Kutzler (all from Oregon State University). The objective was to assess the effect of feeding milk to adipose stem cells. By using pig as animal model, we analyzed the transcriptome of the porcine adipose stem cells besides the analysis of the miRNA in circulating exosomes and milk exosomes, besides performing in vitro adipogenic differentiation of the adipose stem cells. Our data revealed that feeding milk affects the biology and the transcriptome of the adipose stem cells, but, different than what originally hypothesized, the effect was not due to milk exosomes, as indicated by the lack of a vertically transfer (i.e., milk exosomes were not detected in circulation) and by the analysis of the transcriptomic data. https://lnkd.in/gZA5ZHy3

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We are thrilled to introduce Nahid Moradi, MD, a dedicated Stanford Data Ocean graduate and medical doctor from Isfahan University of Medical Sciences in Iran who is currently engaged in translational and clinical research focusing on cancer pathophysiology and treatment. In this testimonial, Nahid shares her enlightening experience with the Stanford Data Ocean platform. Having studied R programming and Python for the past two years, she found the program to be the perfect blend of medical science and data science. The platform offered a user-friendly interface with well-designed Jupyter notebooks, making it easy to navigate and practice coding. Nahid particularly appreciated the AI tutor, which provided insightful guidance whenever she faced challenges. Nahid's favorite aspect of the program was how the courses were tailored for individuals at any level of knowledge in medical science and programming. The practical examples in areas like image analysis, omics, and clinical data allowed her to see how data science could be applied directly to her research. Looking ahead, Nahid plans to leverage the knowledge she gained from Stanford Data Ocean in her ongoing research in cancer pathway physiology and treatment. She aims to integrate deep learning and neural networks with clinical practice image data, such as CT, MRI, and pathology samples, to enhance diagnostic accuracy and improve patient outcomes, especially in cancer care. Nahid emphasizes the importance of bioinformatics, noting that in today’s era, combining medical knowledge with computational tools is essential for advancing diagnostic and therapeutic approaches. She highly recommends the Stanford Data Ocean program to researchers and students in biology and medicine who are interested in integrating data science with clinical science. Join us in celebrating Nahid’s achievements and her exciting journey at the intersection of medicine and data science! We remain committed to empowering women across the globe, with a special focus on the Middle East, Africa, and South America. Through our scholarships, we support their educational and professional development, ensuring they have the necessary resources to thrive and make a lasting impact in their communities. Start your bioinformatics journey with Stanford Data Ocean: https://lnkd.in/ggsKFHWG Fundamentals of Data Science in Precision Medicine and Cloud Computing: https://lnkd.in/dKeqBUn3 Fundamentals of AI/ML in Precision Medicine: https://lnkd.in/dx5UR-SR We believe that anyone who wants a precision medicine education should be able to get one. If you earn less than 70k/yr, you are eligible for a scholarship. Apply here: https://lnkd.in/eqyCP2eZ #DeepData #PrecisionMedicine #Bioinformatics #AI #ML #AIHealthcare #DataScience #ComputationalBiology #Python #MD #Certification #Stanford #StanfordMedicine #Iran #Testimonial #CancerResearch

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What may #AbuDhabiMotors #BMW have to do with lab tours during UAE BioTech Symposium ? ?? 😎 Follow the page for any news inshallah. ( &Jason as CEO of Speedmaster ™ I have a personal question in the vid for you too... ) For me, it was the lab tours to the few but world class research facilities that was my due diligence in deciding to make the move to #AbuDhabi. It’s better than the best I’ve seen at The Rockefeller University where I was a student in a top The Nobel Prize winning lab This is a new sector that is now primed for growth. When Dubai and Abu Dhabi built their cities in record time, imagine what they can do in BioTech in no time. Our event targets U.S. BioTech owners & execs considering the a move, and/or other collaboration and business opportunities. Come meet the people who built companies, newly exploring the UAE. #Comeridewithme @uaebiotechsymposium Folllow the page for all exciting developments as they may be formally announced

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Researchers, from the National Institutes of Health and the Keck School of Medicine of USC, have successfully used AI to reprogram cancer cells into tumor-fighting immune cells. By converting glioblastoma cells into dendritic cells, they've achieved a significant increase in survival rates for mice with this deadly brain cancer. This is a major leap forward in immunotherapy. Immunotherapy works by leveraging the body’s own immune defenses to recognize and eliminate cancer cells or pathogens. Bispecific antibodies (BsAbs) can enhance this process by serving as bridges between immune cells and tumor cells, facilitating targeted destruction of malignant cells and leading to improved clinical outcomes. At evitria, we offer comprehensive support for researchers exploring the world of bispecific antibodies. We serve therapeutic companies by supporting their drug discovery research and production of new therapeutics. Imagine a future where cancer is treated by the body's own immune system! #Cancer #AI #Immunotherapy #Biotech #evitria

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☑️ *READ ASTRACT BELOW:* Part 2: The model's training utilized biological and physicochemical properties from a dataset containing protective antigens and non-protective proteins of ESKAPE pathogens. Conventional autoencoders based strategy was employed for feature encoding and selection. During the training process, seven machine learning algorithms were trained and subjected to Stratified 5-fold Cross Validation. Random Forest and Logistic Regression exhibited best performance in various metrics including accuracy, precision, recall, WF1 score, and Area under the curve. An ensemble model was developed, to take collective strengths of both the algorithms. To assess efficacy of our final ensemble model, a high-quality benchmark dataset was employed. VacSol-ML(ESKAPE) demonstrated outstanding discrimination between protective vaccine candidates (PVCs) and non-protective antigens. VacSol-ML(ESKAPE), proves to be an invaluable tool in expediting vaccine development for these pathogens. Accessible to the public through both a web server and standalone version, it encourages collaborative research. The web-based and standalone tools are available at https://lnkd.in/eYRDTX2W. Nasir S, Vaccine. 2024 Sep 17;42(22):126204. doi: 10.1016/j.vaccine.2024.126204. Epub 2024 Aug 9. PMID: 39126830 #Gesundheit #Bildung #Fuehrung #Coaching #Mindset #Motivation #Gehirn #Neuroscience #Psychologie #Persoenlichkeitsentwicklung #Kindheit #KeyNoteSpeaker #Humangenetik #Biochemie #Neuroleadership #Ernaehrung #Transformation #Stress #Demografie #Gender #Age #interkulturelleKompetenz #Epigenetik #Veraenderung #EmotionaleIntelligenz #Change #Gesellschaft #Organisationsentwicklung #Philosophie #Beratung # Quantum

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🎙️ New episode on Getting to Know Your Research! 🎉 In episode seven, Dr. Dawn Eichenfield and Dr. Jennifer Sui discuss their 2022 PeDRA Research Fellowship project titled Characterization of non-coding genetic loci and transcription factors that drive the development of linear morphea. Listen to learn about the many collaborations needed to propel a study like this. 🎧 Listen on PeDRA Pearls or click here 👉 https://lnkd.in/eG5Atjeg #PeDRA #pedraresearch #dermatology #pedsderm #dermresearch #dermnerds #academicdermatology #dermpodcast #morphea

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Exciting news for those interested in inflammation and brain health! 🧠 I'm thrilled to announce that I'm working with Sage Cerebro to develop SageSignal™, the world's first at-home diagnostic that measures inflammation in your brain, also known as neuroinflammation. Why is this a game-changer? High neuroinflammatory levels are associated with a wide range of health concerns, including: - Anxiety 😰 - COVID brain fog 🌫️ - Attention and mood disturbances 😔 - Poor sleep quality 😴 Moreover, neuroinflammation is a key marker for identifying diseases such as Alzheimer's & Dementia, and it's also now effective at predicting your risk of stroke. 🩺 This incredible innovation comes from the brilliant minds at UCLA, including my colleague Jason Hinman's lab. Their tremendous work paves the way for accessible, at-home brain health monitoring. 👨‍🔬👩‍🔬 If you're interested in measuring your neuroinflammation from the comfort of your own home, join our waitlist at Sage Cerebro today! 🙌 Join the Waitlist → https://sagecerebro.com/ For more information, check out this article from the San Francisco Chronicle: https://lnkd.in/geTypdpF #SageCerebro #Neuroinflammation #BrainHealth #Alzheimers #Dementia #Stroke #Innovation #HealthTech

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Paper-based sensors may lead to rapid detection of heart attacks National Science Foundation (NSF) PATHS-UP Engineering Research Center UCLA Henry Samueli School of Engineering and Applied Science California NanoSystems Institute at UCLA ECE Department UCLA Department of Bioengineering

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UC Davis researchers have developed a rapid, noninvasive tool to track the neurons and biomolecules activated in the brain by psychedelic drugs. The protein-based tool, which is called Ca2+-activated Split-TurboID, or CaST, is described in research published in Nature Methods. There has been mounting interest in the value of psychedelic-inspired compounds as treatments for brain disorders including depression, post-traumatic stress disorder, and substance use disorder, among others. Psychedelic compounds — like LSD, DMT and psilocybin — promote the growth and strengthening of neurons and their connections in the brain’s prefrontal cortex. Those afflicted with brain disorders showcase signs of neural atrophy in this region. “It’s important to think about the cellular mechanisms that these psychedelics act upon,” said Christina Kim, an assistant professor of neurology at the UC Davis Center for Neuroscience and an affiliate of the Institute for Psychedelics and Neurotherapeutics. “What are they? Once we know that, we can design different variants that target the same mechanism but with fewer side effects.” This research provides scientists with a new technique that could be used to track step-by-step the molecular signaling processes that lead to these compounds’ beneficial neuroplastic effects. What’s more, CaST accomplishes the task of cellular tagging in rapid time, taking 10 to 30 minutes rather than the hours typical of other tagging methods.     “We designed these proteins in the lab that can be packaged into DNA and then put into harmless adeno-associated viruses,” Kim said. “Once we deliver the CaST tool and these proteins into neurons, then they incubate inside the cells and start expressing.” The research was conducted in collaboration with David Olson, the founding director of the UC Davis Institute for Psychedelics and Neurotherapeutics and a professor of chemistry, and biochemistry and molecular medicine. Learn more: https://lnkd.in/gtdqSTwR 

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Congrats to Alycia Drwencke with the Tucker Lab at UC Davis on her recent publication! Grateful to have had the opportunity to contribute. I believe, a great example of sharing research results even when the outcome wasn't what you had hoped for...avoiding +Publication Bias. I effectively used ethanol epidurals in practice to address post-calving pelvic pain and was sure this was going to be a game changer! Thanks to the disciplined, thoughtful and deliberate design and execution of the study, it changed my game, but not in the way I thought it would. How has my game changed? 1. I am over dehorning (disbudding) - at this point we need supply chain and industry efforts to focus on adopting polled genetics. I have seen 3000 cow herds that are now 100% polled. There is truly no reason 100% of herds should not be actively incorporating polled genetics. This will support progress to advance the trait further. 2. I am over paste - Yup, that is right. I have come full circle. Early in practice, I learned to hate paste. It was rarely used correctly and caused more problems than it solved. Then, we finally realized, if used, it must be EARLY. Applied at day 1-3, we seemed to avoid some of the problem of calves rubbing off the paste. No regrowth if done early, and easier than hot iron when pain mitigation was not being given. Yay! (for ease of application, not for lack of pain management) But man, healing time for paste is nearly 2x as long! And that is when you don't use too much, which many people do. And many continue to use paste WITHOUT pain relief because they think it is not needed. We know better now! A local anesthetic is a must, as are post-op pain meds, no matter what method! The facts are in, disbudding is a pain, for you and the calf! So, if you are using a local, why not use the method that works 100% of the time and heals faster? Yes, you need the right equipment. Yes, you need to restrain. But you need to restrain for the local too. And yes, you get the benefit of knowing it is done right while avoiding the pain of paste getting rubbed on you, other calves or into eyes or other parts. Better yet just used polled! Let's face it, the only one who hates disbudding more than the caregiver is the calf! Let's move towards polled! Until then, let's make sure to use a local and anti-inflammatory. If I was going to pick a method today, I have to admit I would be back, full circle and be opting for hot iron, the earlier the better. Open access! Download and expand your mind for free 😊 If you are a visual learner, a great graphical abstract sums it up! #bekind #push4polled

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Our paper describing a gene regulatory model of a normal, full-term human placenta was published yesterday in Science Advances! Led by Dr. Alison Paquette, 12 placental samples were collected from OHSU and brought to Altius Institute for Biomedical Sciences where we processed them for DNase-seq. This was all the way back at the end of 2018 when I was finishing up my post-doc with John Stam. From this data, Ali and her team were able to map TF binding motifs with co-expression networks to generate a transcriptional regulatory network model. The backbone of this gene regulatory mapping method was developed in Nathan Price's lab at the Institute for Systems Biology (ISB) when I was a grad student by Seth Ament. We previously applied this TRN method to brain data and used it to understand gene expression changes in various disease states, work that made up the bulk of my dissertation (Ament & Pearl et al 2018, Pearl et al 2019). This placenta TRN paper was truly a cross-institutional effort and required countless hours on Ali and other co-authors part to get this data and the subsequent paper out into the world. I hope it serves as a useful reference for studying gene regulatory networks (and transcription factors in particular) in normal, full-term, placental biology, an important cornerstone to our understanding of reproductive health. Congrats all 🎉 Link: https://lnkd.in/gYrrcFUa

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Dr. Shreyas Supekar is a computational biophysicist specializing in Al-driven enzyme engineering, biomolecular modeling, molecular simulations, and drug design. With a Ph.D. from the Technical University of Munich, Dr. Supekar's research focuses on unraveling the complex. dynamics of biomolecular systems, particularly enzymes and their substrates. His work spans a range of topics, from proton-transfer dynamics in cytochrome c oxidase to water dynamics in DNA grooves, contributing valuable insights to the field of biomolecular science. Dr. Supekar is currently advancing his research at the Bioinformatics Institute in Singapore. For more information, get in touch with us at Emerging Trends in Translational Bioinformatics (ET2B) 2024, an International Conference organised by the Department of Bioengineering and Biotechnology, Birla Institute of Technology, Mesra #InnovateWithBiotech #BioengineeringTheFuture #BITBiotechLeads #BioTechBreakthroughs #BITMesra #BITBioTech #BITat75 #BioInformatics #ET2B2024 #Bioinformatics2024 #TranslationalBioinformatics #InnovateInBiotech #DataDrivenHealthcare #FutureOfBioinformatics #BioinformaticsResearch #BITMesraConferences #BiotechInnovation #GenomicsResearch #BioinformaticsTools #ComputationalBiology #DataScienceInBiotech #GeneticEngineering #Biopharmaceuticals #NextGenSequencing #OmicsTechnologies #HealthTech #AIinBiotech #SystemsBiology #PrecisionMedicine #TranslationalResearch

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https://lnkd.in/d9_Vfssr 3D Bioprinting: Technique Prints Human Tissue 10 Times Faster. From Penn State comes HITS-Bio, the system that revolutionizes 3D bioprinting: now printing human tissue is 10 times faster (and ultra-precise).

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