Gretchen Fleming

Wonderful article about Emily Knight and the whole The Engine Accelerator team on the amazing work their doing changing the world with #ToughTech!

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At Two Bear Capital our definition of value-add, lead, early-stage investing is to form a true partnership with the founders we back. We believe that only a small fraction of our return potential comes from us “picking right” when we make our first investment into a company – the vast majority comes from how effectively we can actively help our brilliant founders over the ensuing 3-7 years in achieving the passionate, ambitious, and positive-impact goals that drive them.

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At R7, we felt it was kind of silly for scientists to spend millions of hours per year, manually counting spores in a petri dish. We partnered with Reshape Biotech last year to provide a full-stack automation platform capable of streamlining everything from plate filling to diagnostics, slashing time-to-market by 10x and cutting costs by up to 70%. 🌟 Vision 🔬 : To build a new generation of lab equipment – and the infrastructure behind it – so that scientists and technicians can dramatically accelerate their work. Carl-Emil Grøn Magnus Madsen

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Today, GTMfund’s is excited to announce to launch of Operator, its first incubated company. Max Altschuler (founder of GTMfund) teamed up with co-founder Adam M. (design engineer and 0-1 builder) and co-founder Mark Kosoglow (Outreach employee #1 and former SVP of Global Sales) to create Operator.ai alongside an insanely talented team Pleasant Middelhof, Jeremy Jonas, Carl Gunderson. We've entered a period called “The Great Ignore”. Spam and irrelevant, poorly-automated outbound campaigns are running rampant.   Operator gives you an easy-to-use Growth Engineer that allows you to build and enrich lists with accurate data, and run experiments and queries using AI to generate highly targeted outreach.    Check out their website to get updates, early access, and see how they are taking the world back to 2 touches meant to attract buyers into conversations that convert, instead of 20 touches meant to make sure you hit your activity number: https://www.operator.ai/

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Excited to announce Frist Cressey Ventures' investment in Qualified Health and privileged to partner w/ SignalFire, Healthier Capital, Town Hall Ventures and others!   Healthcare costs are increasing at a faster rate than ever before, with the US spending nearly twice as other wealthy countries and still ranking bottom in outcomes. It's a story you've all heard - - US healthcare is known for astronomical inefficiencies, waste, workforce supply constraints, fragmented access, appalling patient experiences, and driving patients and businesses into debt.   Yes these problems present opportunities. But opportunities are limited to the system's appetite for change, desire and incentive to try something new and the innovation available. At FCV we believe we've hit the trifecta with Generative AI. Generative AI has given us truly transformational tools in the toolkit and the healthcare ecosystem is demanding to absorb its benefits. This perfect collision of supply and demand means healthcare is poised for big change.   Generative AI is everywhere, it's buzzy, it dangles hope and opportunity. But many things need to be true for the Gen AI transformation in healthcare to take hold, such as but not limited to:   💡 Patient lives and data need to remain safe: We believe in a highly regulated and human life-touching sector such as healthcare we must ensure Gen AI can drive to unrivalled savings and improvements in the quality of care WHILE not putting patient lives or data at risk.   💡 Systems need to own their utilization of Gen AI: We believe systems will use some hybrid of external partners and homegrown solutions but importantly will want full control of data provisioning and utilization as well as the ability to solve an unlimited number of nuanced issues and not cookie cutter algorithms.   💡 Costs need to be looked at on an enterprise level: We believe the speed of innovation in Gen AI means costs will continue decreasing dramatically but at an enterprise level this will still not be a small detail. Systems will want the ability to understand costs and delegate as needed for the outcomes desired at the organizational level.   Enter Qualified.   We knew when we met Justin Norden, MD, MBA, MPhil and team we were standing in front of changemakers. These individuals have lived and breathed the true application and implementation of Generative AI far before we were asking ChatGPT to write our emails. In fact, if you’ve ever driven in a Waymo you’ve benefited from past products this team has built.   Qualified Health is on a mission to enforce governance in Gen AI, allow systems to rapidly build for their needs, monitor and make decisions for all GenAI (homegrown and external) and accelerate the value the sector can glean from these new technologies.   Huge shout out to William T., Tommaso Auerbach and Jamie Kuntz for their hard work!

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Excited to announce our investment in Alta Resource Technologies alongside Leonardo Banchik (Voyager Ventures) with participation from Orion Resource Partners, Overture Ventures, and WovenEarth Ventures. Rare earths are critical in products from magnets to ceramics and it's important for the US to develop its own supply chain. While the US has some of the best rare earth resources, separating them has historically proven expensive and environmentally unfriendly. Alta through it's computationally designed and optimized proteins allows the US to bring back rare earth production with a cleaner, lower capex, and lower opex solution - and that's just the beginning. Congrats to Nathan Ratledge and the entire Alta team. Read more here: https://lnkd.in/gbGnAJn3

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One of my proudest moments as an investor occurred today as Alaffia Health announced its series A because it shows how the Aperture® Venture Capital vision of multi-level, multi-generational #impactinvesting is succeeding in the marketplace. Here’s the model in its most basic form : ✅As diverse fund managers with meaningful capital to allocate, we are changing the VC landscape every day just by doing our day jobs. ✅As Black/Brown investors with ~40 years experience collectively, Aperture GPs have access to talent /excellence that others do not, so our portfolio *organically* is more inclusive by race, gender and geography even while optimizing for financial outcomes (all about the alpha). ✅Our most successful portco’s are using financial #innovation to solve market problems that impact underrepresented demographics and underserved communities. Alaffia Health is a shining example of the impact portion of our overall fund thesis, and we couldn’t be prouder of TJ Ademiluyi and Adun Akanni, MPH, PMP - the dynamic brother-sister founder duo whose vision we have steadfastly supported on their journey. Congratulations to TJ and Adun from William Crowder and myself, as well as the whole Aperture team- Marjorie King Philip McKenzie Yves Louis-Jacques Tanvi Lal Michelle Dhansinghani Lisha Bell Katie Kelly Amy Chung Cindy Chong, CFA Brian Fernandes-Halloran Monroe France Jayden Pantel Darren Herman Evan Wladis Neal Triplett Thomas Scriven Peter Ammon Irina Bit-Babik Tim Milanich Rob Rahbari

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Two announcements re: our upcoming first-of-its-kind-event: a) 70+ Attendees are registered! b) The upcoming SiliconXL LaunchAthon is perfect for Job Seekers, Software Engineers and Boston-based Startups For more info or to register, visit ---> https://lnkd.in/efPxJ6Fk www - launchathons - com/boston The upcoming SiliconXL LaunchAthon is designed to provide job seekers with an immersive, hands-on experience that goes beyond traditional training. Through targeted AI coding workshops, attendees will dive deep into advanced AI tools and coding platforms, equipping them with practical skills that employers actively seek. These workshops allow job seekers to build real-world projects in collaboration with industry mentors, creating tangible portfolio pieces that showcase their abilities and problem-solving prowess. For those looking to enter the tech field, our LaunchAthon is an invaluable opportunity to gain relevant, hands-on experience that will make them stand out in a competitive job market. Furthermore, the collaborative environment encourages networking with potential employers and peers, giving job seekers a head start on forming connections that may lead to employment opportunities. For software engineers already in the workforce, our LaunchAthon’s workshops provide a vital opportunity to upskill and explore emerging technologies that might not be part of their current roles. The hands-on experience in AI-powered coding workshops offers a practical way to stay updated with industry trends, experiment with new tools, and learn innovative problem-solving techniques. These workshops encourage engineers to think outside their regular scope of work, sparking creativity and enhancing their adaptability to new challenges. Attending the SiliconXL LaunchAthon can add value not only to their current skill set but also to their role within their organization, as they bring back fresh insights and advanced knowledge that can be applied immediately to drive innovation in their day-to-day work. or startup entrepreneurs, the upcoming LaunchAthon offers an unparalleled opportunity to bring their ideas to life through hands-on experience with cutting-edge AI tools and collaborative workshops. Entrepreneurs will benefit from an environment where they can test, validate, and iterate on their concepts with the guidance of industry mentors and experienced tech professionals. These sessions are designed to accelerate the development process, providing valuable insights into product design, rapid prototyping, and market alignment. Beyond just building, entrepreneurs will also network with potential co-founders, partners, and investors, creating connections that can support their startup’s growth. LaunchAthon is more than an event; it’s a launchpad for entrepreneurial visionaries looking to create impactful, scalable tech solutions in a high-energy, supportive setting.

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I'm so excited to continue supporting Prolific Machines, Inc., and the incredible Deniz Kent, PhD ,Max Huisman, and Declan Jones. Today's cellular biology processes are incredibly expensive, inefficient, imprecise, and sometimes purely ineffective. These processes are used from everything from making antibodies to treat diseases, to fermentation used to make high-value nutritional proteins in baby formula, to whole cuts of cultured meat. Prolific has developed a biology platform that leverages light to guide cell behavior and optimize performance over time using AI. By combining light, bioengineering, hardware, and AI in fundamentally new ways, Prolific can help pharmaceutical, nutritional, and therapeutics companies get to market faster, less expensively, and more efficiently — ultimately in hopes of helping improve outcomes — a mission any of us can get behind. Mark Cuban Peter T. Frederick Blackford Cooper Rinzler David Adelman Darco Capital Breakthrough Energy Michael Schulson Kevin Love Tobias Harris Breyer Capital Charles Besser Brennan Besser Lettuce Entertain You Restaurants https://lnkd.in/ea2TqdQk

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Apply now to get a coveted spot for the Venture Lane B2B Pitch Night Event! 🚀 🥇 On November 19th, Venture Lane | Startup Hub is hosting our exclusive Pitch Night 👉 - a rare opportunity for Boston's B2B tech founders to tune their pitch and get in front of awesome mentors, investors, and industry leaders. ⏰ Apply by November 1st to secure your spot! 📲 Find the application link in the comments below. #B2BTech #Startups #Fundraising #BostonStartups #PitchNight #VentureLaneStudio

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Thrilled to announce the launch of our inaugural edition of Beyond Benchmarks at Emergence Capital. This comprehensive report dives deep into the metrics and trends shaping the early-stage enterprise cloud market. A huge thank you to our VC partners and contributors for making this possible! Here's a sneak peek of our findings: --> 60% of companies have already integrated GenAI into their service offerings, with another 20% planning to do so this year. --> While most companies use OpenAI as their primary LLM, many are experimenting with multiple models. We’re seeing a trend toward intelligently routing GenAI inference requests based on cost, performance, and security. --> Companies that have implemented GenAI are showing promising results, with a 7% higher NDR compared to those that haven’t. Beyond Benchmarks goes further with more GenAI trends, insights on the current fundraising environment, and key performance metrics. Our goal is to provide founders and their teams with valuable benchmarks to help them make better-informed decisions. At Emergence Capital, we're committed to helping founders build iconic companies. Dive into the full report here: https://lnkd.in/g6bnvAZM

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I really enjoyed breaking in our new studio to sit down with Temporal Technologies Co-Founders Samar Abbas and Maxim Fateev for the latest episode of Founded & Funded. Temporal was founded in 2019 based on an open-source microservices orchestration engine project but is the result of a more than decade-long partnership between the two co-founders that spanned their time working on different iterations of the same thing at AWS, Microsoft, and Uber. In this episode, Samar, Maxim, and I dive into the challenges of building an open-source ecosystem while also working on a commercial offering and scaling a successful company, how to navigate and adjust a product roadmap in an ever-changing world of AI and large language models, and how to successfully build an early startup team, navigate through a CEO transition, and bring on a startups first independent board member. It's a very compelling conversation and a must-listen for every builder out there. Watch the full episode on YouTube: https://lnkd.in/gymf9sES Find other platforms and the transcript on our website: https://lnkd.in/ggRtnKtM Be sure to subscribe to our channel for more deep dives into cutting-edge technologies and the minds behind them. Don't forget to like, comment, and share this conversation if you found it valuable!

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The (Healthcare) Ground Beneath Our Feet… This year it is likely that over $10 billion will be invested in the digital health sector – a robust amount, no doubt, but inconsequential when compared to the amount of capital tied up in healthcare real estate assets, which is estimated to be $1.2 trillion by Jones Lang Lasalle. Of that amount, approximately $790 billion is in the hospital sector while the remaining $490 billion is in medical office assets. It is estimated that there are 48.6k facilities with 3.4 billion square feet of healthcare real estate, 42% of which are owned by REITs and another 33% held by other private investment vehicles. Much of the digital health investment is meant to make the physical healthcare infrastructure more productive: greater operating efficiencies, greater patient throughput, more relevant personalized care models with better outcomes. As the healthcare system is being pushed to be more distributed to lower cost sites of care, accelerated now by the rapid proliferation of automation and AI capabilities, the potential impact on healthcare infrastructure assets will be profound. Thoughts on what that might look like... https://lnkd.in/eTfAdUbS #digitalhealth Flare Capital Partners

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🎃 Ready to carve out your path to Product-Market Fit?🎃 Join Companyon Ventures’ Behind the Curtain roundtable tomorrow (Oct 30) with Michael Ho, Firas Raouf, Eric Morgan, and Hersh Tapadia as they 'exorcise' the mysteries of PMF. Don’t ghost us—RSVP in the comments 👻 https://lnkd.in/emCJcn4w #emergingmanager #venturecapital #productmarketfit

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Insightful look into bioplatform strategy, and what it takes to raise a Series A from my partner, Omri Amirav-Drory: https://lnkd.in/dFv7GbF6

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We're absolutely thrilled to announce a monumental milestone for Flo Health Inc.! After years of dedication to women's health, Flo, a long-standing member of the Target Global family, has secured over $200 million in Series C funding led by General Atlantic.This incredible investment propels Flo's valuation beyond $1 billion, officially making it a unicorn – a rare and remarkable feat in the femtech space. This accomplishment isn't just about numbers. It's a testament to the power of prioritizing women's health. Flo has seen phenomenal growth over eight years, becoming the #1 downloaded app in the Health & Fitness category. Today, Flo empowers nearly 70 million monthly active users (MAUs) and boasts close to 5 million paid subscribers. Notably, 1 in 4 US women trust Flo, solidifying its position as a leader in the global movement for women's health. But this is just the beginning! This investment fuels Flo's mission to revolutionize female healthcare experiences worldwide. By directing resources towards areas of critical yet unmet needs (which, let's be honest, encompasses a vast majority of women's health!), Flo will continue to be a driving force for positive change. Congratulations Dmitry Gurski,Yuri Gurski, and the entire Flo Health Inc. team! More in the Financial Times here ---->https://lnkd.in/dJZdajM4

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I'm excited to share my thoughts about closing our latest fund at Companyon Ventures. Raising a VC fund as an emerging manager is tough enough without the added challenge of rising interest rates and inflation, punctuated by the 2023 banking crisis unfolding during our fundraising cycle. After countless meetings and hearing "no" more times than we'd like to remember, we're grateful for the support and introductions from our LPs and fellow VCs like Bob Mason. We surpassed our minimum target, raising $41M with an additional ~$20M from our LPs available for SPVs in our companies, bringing our AUM close to $100M. While small in today's VC world, we're very proud of how we've deployed that capital. My partners Firas Raouf, David McFarlane, and Ronny Chatterjee did much of the heavy lifting with the fundraising, but our entire team significantly contributed to the effort. Here are a few highlights and thank-yous we’re excited to share: 🙏 First, a huge thanks to the founders who accepted our investment during our fundraising process. Your powerful visions and amazing execution proved to our existing and prospective LPs that we can identify and attract some of the best founders in the industry. Thanks Stephen Gendron, Doug Neumann, Hersh Tapadia, Avante Price, Eli Taylor-Lemire, Zaid Rahman, Daniel Pelaez, and Ali Ansari! 🌟 With a larger fund than our 2020 fund, our focus and thesis have not changed. We believe we are the top firm to lead late seed, post-seed, and early Series A rounds when companies are navigating the tricky transition from a founder-led startup to the first stages of a scalable enterprise. 💰 We launched a new Capital Markets function in this fund built by my colleague Ronny Chatterjee. This has been massively impactful for our portfolio CEOs. Ronny has showcased our portfolio to more than 200 Series A, B, Growth, and PE funds, and dozens of debt providers with great success. His job is to find the right follow-on capital for our portfolio companies while saving our CEOs countless hours of blindly prospecting for dollars. 🛠 We still average ~4 new investments each year from the thousands of companies we encounter. It’s tough to pass on many of them, but our approach of offering deeply embedded GTM talent and playbooks requires a concentrated portfolio approach so we can provide the attention and bandwidth that our founders expect. 📈 We’re proud that about half of our existing portfolio from this fund and our prior fund (2020) have either already crossed the critical $10M ARR threshold or will likely do so within the next year. We're confident that many more will follow shortly after. Most were at or below $2M ARR when we invested. 99% of that operational success can be attributed to those founders, but we like to think that our 1% was well-timed and impactful. Thank you to everyone in our community who has supported us in so many different ways! https://lnkd.in/eFauhT4Q #venturecapital

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If you enjoyed our first blog on the metrics that matter for Verticalized SaaS then don't miss on the Part II of the series where my colleagues Devraj Hom Roy and Matt Schaar discuss the strategic and operational choices to improve these operational indicators. https://lnkd.in/g5QkCrcH

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Are you better off being an angel investor or an S/EIS fund investor? When you’re thinking about making early-stage investments for the first time, you have a choice of two main options: Invest directly into startups or invest into funds that invest a portfolio of startups for you. * Direct (Angel) Investing: You select and invest in individual startups, taking on the tasks of sourcing, decision-making, and managing your investment. * Fund Investing: You invest in a fund that invests and manages a portfolio of startups for you, handling the sourcing, investing, and management on your behalf. There’s a romantic notion attached to the idea of investing in startups - we can play Dragon’s Den and discover the next Reggae Reggae Sauce. For every Reggae Reggae Sauce, though, there are 100 other startups that fail along the way. The first rule of startup investing, whether you do it directly or through funds, is that you need to build a portfolio of companies to cope with inevitable losses. Investing directly into startups as an angel investor suits those with access to credible, high-potential startups. It’s a hands-on role that requires active involvement to source the startups. Further, most of the best startups have minimum investment amounts of £10k or £20k, which means direct investors often need a lot of available capital to properly manage risk by investing in a portfolio of companies. This doesn’t need to be done all at once, but that is the mindset every good angel investor should have when setting out on the journey. Fund investing, on the other hand, suits those who prefer to invest indirectly, relying on the access, experience, and skill of the Fund Manager to invest and manage the investments for you. It’s a hands-off approach, with investors not involved in management and simply kept updated on a regular basis. Because funds pool your money with others to invest in a portfolio of startups in one go, this can be a more effective way of managing risk while investing smaller amounts. Most SEIS and EIS funds have £10k minimums for investors, meaning you could build a portfolio of 10-20 companies for just £10k, rather than needing to invest £10k into 10-20 separate companies as a direct angel investor. Whichever approach you choose should depend on your resources, access, interests, and time. Regardless, though, a key principle to follow is to not be reliant on the success of just one or two companies; instead, build a portfolio of startups to manage risk and cope with inevitable losses along the way. Which one is best for you? Let me know if you’d like to chat. Capital at risk. For professional investors only.

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