“Ed is one of the smartest most helpful and at the same time most humble person I know. During our work together, Ed has supported the team through a difficult study and was able to develop a new and distinctive way to solve a terribly complicated problem that our client faced. All the time Ed offered his support to myself and two other brand new analysts pushing the answer forward and developing our skills at the same time.”
About
Experienced analytics professional with a demonstrated history of building and leading…
Activity
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Thank to all that attended, and to Nathan King for sharing his summary!
Thank to all that attended, and to Nathan King for sharing his summary!
Liked by Ed Marx
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Happy first day of fall, #PennState! 🍂🍁 What is your favorite fall activity around campus? 🎃
Happy first day of fall, #PennState! 🍂🍁 What is your favorite fall activity around campus? 🎃
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Experience
Education
Publications
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Optimizing Personalized Bone Marrow Testing Using an Evidence-Based, Interdisciplinary Team Approach
American Journal of Clinical Pathology
Objectives: To address the overuse of testing that complicates patient care, diminishes quality, and increases costs by implementing the diagnostic management team, a multidisciplinary system for the development and deployment of diagnostic testing guidelines for hematologic malignancies. Methods: The team created evidence-based standard ordering protocols (SOPs) for cytogenetic and molecular testing that were applied by pathologists to bone marrow biopsy specimens on adult patients. Testing on…
Objectives: To address the overuse of testing that complicates patient care, diminishes quality, and increases costs by implementing the diagnostic management team, a multidisciplinary system for the development and deployment of diagnostic testing guidelines for hematologic malignancies. Methods: The team created evidence-based standard ordering protocols (SOPs) for cytogenetic and molecular testing that were applied by pathologists to bone marrow biopsy specimens on adult patients. Testing on 780 biopsy specimens performed during the six months before SOP implementation was compared with 1,806 biopsy specimens performed during the subsequent 12 months. Results: After implementation, there were significant decreases in tests discordant with SOPs, omitted tests, and the estimated cost of testing to payers. The fraction of positive tests increased. Clinicians reported acceptance of the new procedures and perceived time savings. Conclusions: This process is a model for optimizing complex and personalized diagnostic testing.
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Limited Utility of Fluorescence in Situ Hybridization for Common Abnormalities of Myelodysplastic Syndrome at First Presentation and Follow-up of Myeloid Neoplasms
Leukemia & Lymphoma
Fluorescence in situ hybridization for abnormalities common to myelodysplastic syndrome (MDS FISH) is often used with traditional karyotype in the diagnosis and monitoring of myeloid neoplasms. However, its value in these roles has been questioned. To evaluate its utility, we compared MDS FISH results with karyotype in 544 bone marrow specimens obtained for diagnosis (180 cases) or follow-up (364 cases) of myeloid neoplasia. We found excellent concordance between FISH and karyotype, such that…
Fluorescence in situ hybridization for abnormalities common to myelodysplastic syndrome (MDS FISH) is often used with traditional karyotype in the diagnosis and monitoring of myeloid neoplasms. However, its value in these roles has been questioned. To evaluate its utility, we compared MDS FISH results with karyotype in 544 bone marrow specimens obtained for diagnosis (180 cases) or follow-up (364 cases) of myeloid neoplasia. We found excellent concordance between FISH and karyotype, such that FISH is rarely abnormal (1.7% at diagnosis and 3.0% at follow-up) in cases with normal karyotype. Even in the rare discordant cases, the abnormal FISH has little or no clinical value. Thus, we propose that this test should be limited to cases with inadequate karyotype only. Such guidelines could result in significant cost savings with no impact on patient diagnosis.
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Confluence of Policy and Leadership in Academic Health Science Centers
Radcliffe Publishing
Co-authored chapter: Contemporary Challenges in Academic Health Science Center Financial Management
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Organizations
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Penn State Schreyer Honors College
External Advisory Board
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Penn State Schreyer Honors College
Scholar Alumni Society Board
- Present
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Fantastic conversation today on Tennessee's vaccine rollout hosted by NashvilleHealth. Sincere thanks to Tennesse Department Of Health Commissioner…
Fantastic conversation today on Tennessee's vaccine rollout hosted by NashvilleHealth. Sincere thanks to Tennesse Department Of Health Commissioner…
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It was a pleasure to be a guest on Tennessee Voices. I enjoyed speaking about COVID, personal well being, and the path forward.
It was a pleasure to be a guest on Tennessee Voices. I enjoyed speaking about COVID, personal well being, and the path forward.
Liked by Ed Marx
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The person that can make the complex easy to understand will have the attention of the room. #communication
The person that can make the complex easy to understand will have the attention of the room. #communication
Liked by Ed Marx
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