Wireframe Ventures

Five years ago we led the pre-seed round in Enveda, inspired by founder Viswa Colluru, PhD's ambitious goal of unlocking the 99% of nature’s chemistry yet to be explored, and translate it into new medicines. Enveda is now delivering on that promise with a pipeline of ten development candidates, including their first clinical-stage program - ENV-294 for Atopic Dermatitis, a condition that affects over 30 million Americans. And today the company announced a new $130M Series C financing to power up their groundbreaking, AI-driven approach that’s already proven to develop drug candidates 4X faster than industry norms. We’ve been proud supporters of Enveda since the very beginning of their journey to improve human health and redefine drug discovery. This milestone is a testament to their exceptional team, unwavering focus, and groundbreaking science. Congratulations! https://lnkd.in/gSWQivgr

Celebrating a big moment at Wireframe Ventures - we are thrilled to announce the promotion of Lily Bernicker to Partner 🌟 You can read her thoughts below on this meaningful milestone for her, and our firm

Our portfolio company Sora Fuel is focused on reducing the significant CO₂ impact of air travel. Their recent partnership with Emerging Fuels Technology (EFT) will enable them to scale sustainable aviation fuel (SAF) production efficiently and affordably. Sora’s carbon capture and air-to-fuel process with EFT’s fuel synthesis capabilities create a streamlined path to power flights using only air, water, and renewable energy. As Sora Fuel CEO Gareth Ross puts it, their collaboration with EFT is “game-changing for the SAF industry.” https://lnkd.in/eHrdWtWG

The manufacturing process in semiconductors, batteries, and aerospace is filled with hidden inefficiencies and blind spots. Jared O'Leary, co-founder and CEO of SirenOpt, recently highlighted these pain points on the Climate Capital Podcast: “People don’t always realize how challenging it is to consistently produce materials for things like batteries and semiconductors—the tiniest differences in production can make or break the outcome, and we help manufacturers understand those differences in real-time.” By giving manufacturers the ability to refine and improve processes on the fly, SirenOpt is delivering vital support to industries that are powering the energy transition. Listen to their conversation: https://lnkd.in/e_-tdpeU

Wireframe portfolio company, LevelTen Energy, just facilitated ENGIE's largest U.S. solar project to date. Through LEAP™ (LevelTen Energy’s Accelerated Process), co-developed with Google, ENGIE North America and Google have signed a 90-MW Power Purchase Agreement (PPA) to power Google’s Texas operations. Proud to support visionary founders like Bryce Smith, who are advancing clean energy on a transformative scale. https://lnkd.in/ePyfJqYW

Our portfolio company Bedrock Energy is bringing scalable, zero-carbon heating and cooling to commercial buildings, campuses, and hospitals. Bedrock’s technology makes geothermal viable in dense urban areas, providing cost savings and a renewable energy source that eases grid demand. Recently featured on the MCJ podcast, Co-Founder & CEO Joselyn Lai shared Bedrock’s mission to harness geothermal energy as a powerful renewable resource right under our feet: “The future of energy isn’t just clean—it’s consistent, local, and accessible.” Listen now: https://lnkd.in/e2a_fkNx

Our portfolio company, Gridware, was recently featured on CBS for their wildfire prevention technology. Using AI-driven sensors, Gridware identifies risks on power lines and alerts utilities in real time — helping them stop potential fires before they start. For co-founder Timothy Barat, the mission is personal: “In my years as a lineman, I saw the catastrophic impact that unmonitored power lines could have on entire communities. Building technology that detects these dangers early allows us to protect people and ecosystems before it’s too late.” With 13,000 sensors already deployed across eight states, Gridware’s technology is leading a more proactive approach to fire prevention and grid resilience. https://lnkd.in/ea7VcYG7

Hurricanes expose the challenges insurers face when assessing widespread damage. CNBC featured our portfolio company Near Space Labs, highlighting how they are reimagining disaster response with AI-enabled balloon cameras that capture detailed, high-res imagery in real-time. Founder & CEO Rema Matevosyan explains: “Insurance companies are able to get access to information right after the catastrophe and assess damage and pay out claims within days instead of weeks.” Near Space Labs is setting a new standard in post-disaster assessment, accelerating recovery and building resilience as climate events become more frequent. https://lnkd.in/dURt3Zmr

We’ve been enthusiastic supporters of Bruce Beutel and Passkey Therapeutics since their pre-seed round. Read why we were so excited to back this team & their pioneering approach to unlocking complex disease biology through a new class of multifunctional drugs 🧬 https://lnkd.in/eYFvGbFm

We’ve been enthusiastic supporters of Bruce Beutel and Passkey Therapeutics since their pre-seed round. Read why we were so excited to back this team & their pioneering approach to unlocking complex disease biology through a new class of multifunctional drugs 🧬 https://lnkd.in/eYFvGbFm