https://lnkd.in/efvZkUvh ⬅️ This bioRxiv preprint by Dr. Ross Marklein and colleagues at FDA-CDER and The University of Georgia explores how mesenchymal stromal cell-derived #extracellularvesicles (MSC-EVs) might one day help treat neurodegenerative diseases by modulating brain pericytes, key players in blood-brain barrier integrity and inflammation. They developed a novel method to assess pericyte shape changes, while showing that MSC-EVs could down-regulate hallmarks of neuroinflammation. RoosterBio is proud to support this important research via its MSCs, bioprocess expertise, and high-performance culture media. #neurodegenerativedisease #inflammation #celltherapy #exosomes #celltherapyresearch #regenerativemedicine #stemcelltherapy #stromalcells
RoosterBio Inc.
Biotechnology Research
Frederick, Maryland 10,390 followers
Accelerating hMSC & Exosome Product & Process Development to Fuel Rapid Implementation of Scalable Advanced Therapies
About us
RoosterBio accelerates human mesenchymal stem/stromal cell (hMSC) and exosome/extracellular vesicle (EV) product and process development to fuel the rapid implementation of scalable advanced therapies. Our high-quality hMSCs, bioprocess media, genetic engineering tools, and exosome production solutions are paired with expert bioprocessing knowledge to progress therapeutic developers from concept to first-in-human testing and commercial manufacturing at reduced cost and increased productivity. With optimized, scalable processes, Type II Drug Master Files, and cGMP products, we have enabled therapeutic programs to traverse their path to clinical translation in under one year. RoosterBio is driven by our client's success and creating a world where safe and effective advanced therapies are rapidly developed and widely available on a global scale.
- Website
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http://www.roosterbio.com
External link for RoosterBio Inc.
- Industry
- Biotechnology Research
- Company size
- 51-200 employees
- Headquarters
- Frederick, Maryland
- Type
- Privately Held
- Founded
- 2013
- Specialties
- Mesenchymal Stem/Stromal Cells, Bioprinting, Tissue Engineering, Cell Therapy, Regenerative Medicine, Biomedical Engineering, Bioprocessing, Process Development, Democratizing Cell Technologies, Exosomes, Extracellular Vesicles , Advanced Therapies, Biotechnology, Cell and Gene Therapy, Stem Cell Research, and Biomanufacturing
Locations
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Primary
5295 Westview Dr
Frederick, Maryland, US
Employees at RoosterBio Inc.
Updates
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As published in Nature Communications, scientists at SHIFTBIO INC. in collaboration with RoosterBio developed SIRP-EVs (engineered mesenchymal stem cell-derived vesicles) as a new treatment for ALF (acute liver failure). This publication highlights the scalable 3D #bioreactor process developed to manufacture high yields of SIRP-EVs coupled with an effective downstream process that concentrates EVs and removes impurities. MSC-derived SIRP-EVs outperform HEK cell-derived versions, highlighting their unique therapeutic potential. RoosterBio is proud to support this groundbreaking research and is especially privileged to play a part in these exciting and ongoing preclinical advances with ShiftBio's innovative team. Read it here: https://lnkd.in/gWG_T6rV #extracellularvesicles #exosomes #stemcellresearch #celltherapy #regenerativemedicine #advancedtherapy #liverfailure #molecularmedicine #bioprocessing
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RoosterBio's QuickShip™ hMSCs are human mesenchymal stromal/stem cell banks manufactured from your selected tissue and donor using highly consistent and reproducible MSC production systems. Whether you need millions or billions of cells, spend less time deriving and culturing cell banks and more time generating data with confidence in your study's reproducibility. Request a quote here ➡️ https://lnkd.in/dGBD8ijG #celltherapymanufacturing #celltherapy #stemcelltherapy #stemcells #stromalcells #mesenchymalstemcells
QuickShip™ hMSCs
https://www.roosterbio.com
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Looking ahead, rigorous characterization is what will allow extracellular vesicle-based discoveries to move toward clinical applications with clarity and credibility. #MISEV offers consensus-driven recommendations that enable researchers to design robust experiments, interpret results confidently, and ensure reproducibility. Learn more about "the spirit of MISEV" in our latest blog. ➡️ https://lnkd.in/ed7iVa3d #extracellularvesicles #exosomes #celltherapy #celltherapymanufacturing #microvesicles #advancedtherapies
The Spirit of MISEV
https://www.roosterbio.com
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In the past decade, extracellular vesicles/exosomes have shown promise for treatment of a variety of diseases and moved into the clinic with dozens of reported clinical trials globally. As the number of clinical trials increases, exosome production requires robust, scalable, and cost-effective processes. In this collaborative study with Cytiva, RoosterBio developed process parameters that can be tailored for a wide variety of therapeutic exosome programs and allows for maximum exosome recovery while maintaining quality. ➡️ Download it here: https://lnkd.in/ez7_QTvH #exosomes #extracellularvesicles #whitepaper #appnote #scalablemanufacturing #bioprocess #bioprocessdevelopment #advancedtherapies #stemcells
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This blog post explores chimeric antigen receptors displayed on #exosomes and extracellular vesicles (EV-CARs) that could offer a cell-free, scalable alternative to CAR-T therapies. This modality promises fewer side effects like #cytokine release syndrome, superior penetration of solid tumors, and #bioproduction from abundant and standardized allogeneic cell sources. Though still in early development, EV-CAR technology shows potential to revolutionize cancer treatment and more in a few years. 🔗 https://lnkd.in/eTZt44Ph #extracellularvesicles #antigen #cart #tcell #immunotherapies #cancerresearch #geneticengineering
EVs Answer to the CAR-Tease: Targeted Exosomes to Speed Toward Next-Gen Immunotherapies
https://www.roosterbio.com
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📑 This study led by McGill University's Professor Lisbet Haglund, analyzed #extracellularvesicles (EVs) from intervertebral disc (IVD) cells across tissue degeneration grades. Proteomic analysis revealed 88.6% of EV proteins were shared, but their abundance varied. That is, mildly-degenerate EVs had distinct extracellular matrix-related cargo. Enabled in part by RoosterBio's EV collection medium (RoosterCollect™-EV), these findings shed light on IVD degeneration mechanisms, suggesting biomarkers and therapeutic targets for low back pain. Read more: https://lnkd.in/e5_3CqDh #exosomes #lowerbackpain #microvesicles #biomarkers #nanoparticle #chromatography #westernblot #celltherapy
The proteomic landscape of extracellular vesicles derived from human intervertebral disc cells
onlinelibrary.wiley.com
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To empower and not to haunt, "the spirit of MISEV" is a distillation of best practices for #extracellularvesicle researchers. MISEV2023 offers consensus-driven recommendations that enable researchers to design robust experiments, interpret results confidently, and ensure reproducibility. Looking ahead, rigorous characterization is what will allow EV-based discoveries to move toward clinical applications with clarity and credibility. Keep reading➡️ https://lnkd.in/ed7iVa3d #exosomes #misev #isev #extracellularvesicles #exosome #advancedtherapies
The Spirit of MISEV
https://www.roosterbio.com
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🔬🐓 At RoosterBio, there are numerous women whose skilled work and innovative ideas push our team to reach new heights. That's why every International Day of Women and Girls in Science we celebrate their achievements and the inclusion that fosters diverse thought and solutions in all fields. These women are shaping the future of science and all of them are role models for the next generation of girls interested in STEM! #internationaldayofwomenandgirlsinscience #WomeninSTEM #womeninbio #Womeninscience Zoe Roussos
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📢 Last call to join RoosterBio's #webinar this Wednesday for an in-depth discussion on AgentV™-DSP and how to achieve up to 10X #exosome yield. Register here: https://lnkd.in/ePHwTp-6 #exosomes #bioprocess #stemcelltherapy #advancedtherapies #celltherapymanufacturing #regenerativemedicine
🗓️ AgentV™-DSP is a solution specifically designed to overcome downstream process-related particle loss by addressing filtration problems. AgentV provides novel processing advantages such as enabling use of smaller cutoff filters, greater filter loading capacity, and greater #exosome yield through filtration. The result is 40-70% particle recovery and up to 10-fold increase in particle yield. Learn more in our upcoming webinar on Wednesday, Feb 12th: https://lnkd.in/eQCY4-mC #bioprocessing #downstreamprocessing #celltherapy #extracellularvesicles #bioreactor #microvesicles
Introducing AgentV: The Scalable Solution for 10X Exosome Yield
us02web.zoom.us