CDK4 Gene Mutation
Information about Inherited Mutation
What is ?
is a gene that helps control cell growth. People who are born with changes—called mutations—in their gene have an increased risk for certain types of cancer.
What are the cancer risks associated with a mutation?
People with an in have an increased risk for melanoma and possibly pancreatic cancer.
What can people with a mutation do?
Experts have created guidelines which outline recommendations for managing risk in people with a mutation. There may be family planning concerns and options for people with an inherited mutation.
If you test positive for an inherited mutation, you should inform your close blood relatives (first-, second-, and third-degree relatives) about your test results and encourage them to speak with a genetics expert.
Does everyone with a mutation develop cancer?
Although the lifetime risk for cancer with a mutation is high, not everyone with a mutation develops cancer. Following the guidelines for screening and prevention increases the chances of preventing cancer or catching it at its earliest and most treatable .
More detailed information for people with inherited mutations is highlighted below.
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SIGN UP FOR CONTENT UPDATESInformation for People with an Inherited Mutation
Cancer Risks
Cancer risk estimates are updated based on the latest research. Read about the lifetime risk for different cancers in people with inherited CDK4 mutations.
Risk Management Options
Read about the latest expert guidelines for cancer screening and prevention for people with a CDK4 mutation. Learn about research studies enrolling high-risk patients.
Cancer Treatment Options
Tumor biomarker testing and genetic testing can provide additional clues about which treatments may work best for your cancer. People who test positive for a CDK4 mutation may have additional treatment or clinical trial options available to them.
Other Considerations
Learn additional information about inherited CDK4 mutations and options related to family planning.