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Entry Information
Entry status
(1)
Experimental methods
(3)
Electron Microscopy
(9)
X-ray diffraction
(9)
Solution NMR
(5)
Authors
(145)
Fan F
(5)
Gao R
(5)
Li Z
(5)
Lin M
(5)
Luo C
(5)
Lv Y
(5)
Qiu J
(5)
Trave G
(5)
Wang Q
(5)
Wang Z
(5)
Xu W
(5)
Ye F
(5)
Yu X
(5)
Cousido-Siah A
(4)
Mitschler A
(4)
Bezsonova I
(3)
Chen X
(3)
Podjarny A
(3)
Tarasov SG
(3)
Travé G
(3)
Walters KJ
(3)
Beaudenon S
(2)
Bonhoure A
(2)
Bregnard TA
(2)
Chakraborty D
(2)
Erlandsen H
(2)
Fairchild D
(2)
Howley PM
(2)
Huang L
(2)
Huibregtse JM
(2)
Kater L
(2)
Kempf G
(2)
Kinnucan E
(2)
Korzhnev DM
(2)
Kostmann C
(2)
Masson M
(2)
McEwen AG
(2)
Pavletich NP
(2)
Pol SV
(2)
Sandate CR
(2)
Thoma NH
(2)
Vande Pol S
(2)
Wang G
(2)
Zanier K
(2)
Altschuh D
(1)
Andresson T
(1)
Androphy EJ
(1)
Ansari T
(1)
Arrowsmith C
(1)
Arrowsmith CH
(1)
Babah KO
(1)
Baddock HT
(1)
Baleja JD
(1)
Be X
(1)
Brameyer S
(1)
Bratkowski M
(1)
Bratkowski MA
(1)
Brimer N
(1)
Buel GR
(1)
Cavarelli J
(1)
Chakrabory D
(1)
Chang L
(1)
Charbonnier S
(1)
Chari R
(1)
Chebaro Y
(1)
Chen JJ
(1)
Conrady M
(1)
Conrady MC
(1)
Cura V
(1)
Das C
(1)
Davisson VJ
(1)
DeMarco AG
(1)
Demenge A
(1)
Dengler S
(1)
Dhe-Paganon S
(1)
Dobrzanski C
(1)
Douat C
(1)
Eaton D
(1)
Ebelle DL
(1)
Eberling P
(1)
Fares C
(1)
Feiler C
(1)
Feiler CG
(1)
Ferrario MG
(1)
Foe IT
(1)
Forster A
(1)
Frecot DI
(1)
Gabel CA
(1)
Gogl G
(1)
Hall MC
(1)
Hao Q
(1)
Hong Y
(1)
Howard E
(1)
Howard RT
(1)
Huang WE
(1)
Huc I
(1)
Iftner T
(1)
Iyer S
(1)
Jenkins C
(1)
Jensvold ZD
(1)
More...
Homo / hetero assembly
(2)
hetero
(15)
homo
(8)
Assembly composition
(2)
protein/protein complex
(15)
protein structure
(8)
Assembly polymer count
(5)
tetramer
(6)
trimer
(6)
dimer
(5)
monomer
(5)
hexamer
(1)
Resolution distribution
1.0 - 1.5
(1)
2.0 - 2.5
(3)
2.5 - 3
(5)
3.0 - 3.5
(3)
3.5 - 4
(4)
4.0 - 4.5
(2)
Release year distribution
1995 - 2000
(2)
2000 - 2005
(1)
2005 - 2010
(1)
2010 - 2015
(1)
2015 - 2020
(5)
2020 - 2025
(16)
2025 - 2030
(1)
Journal
(12)
Nat Commun
(7)
Science
(3)
Biorxiv
(2)
J Biol Chem
(2)
To be published
(2)
Angew Chem Int Ed Engl
(1)
Biochemistry
(1)
J Biomol NMR
(1)
J Virol
(1)
Nature
(1)
Protein Sci
(1)
Structure
(1)
Macromolecules
Organism superkingdom
(3)
Eukaryota
(23)
Bacteria
(4)
Viruses
(2)
Organism name
(5)
Homo sapiens
(23)
Escherichia coli K-12
(3)
Escherichia coli
(1)
Human papillomavirus type 18
(1)
human papillomavirus 31
(1)
Molecule name
(12)
E6AP ubiquitin-protein ligase
(23)
HECT-type ubiquitin transferase E3A
(23)
Human papillomavirus E6-associated protein
(23)
Oncogenic protein-associated protein E6-AP
(23)
Renal carcinoma antigen NY-REN-54
(23)
Ubiquitin-protein ligase E3A
(23)
MBP
(3)
MMBP
(3)
Maltodextrin-binding protein
(3)
Maltose-binding protein
(3)
Maltose/maltodextrin-binding periplasmic protein
(3)
Protein E6
(2)
Molecule type
(1)
Protein
(23)
Gene names
(8)
E6AP
(23)
EPVE6AP
(23)
HPVE6A
(23)
UBE3A
(23)
JW3994
(3)
b4034
(3)
malE
(3)
E6
(2)
Interacting Molecules
(8)
Protein E6
(11)
Cellular tumor antigen p53
(5)
Ubiquitin-like protein SMT3
(2)
26S proteasome non-ATPase regulatory subunit 4
(1)
E3 ubiquitin-protein ligase HERC2
(1)
Maltose/maltodextrin-binding periplasmic protein
(1)
Ubiquitin-conjugating enzyme E2 L3
(1)
hybrid foldamer-peptide macrocycle
(1)
Interacting ligands
(8)
ZN : ZINC ION
(6)
GLC : alpha-D-glucopyranose
(4)
PRD_900001 : alpha-maltose
(3)
ACT : ACETATE ION
(1)
CA : CALCIUM ION
(1)
GOL : GLYCEROL
(1)
PEG : DI(HYDROXYETHYL)ETHER
(1)
PRD_900035 : alpha-maltohexaose
(1)
Function and Biology
EC number / name
(1)
2.3.2.26 : HECT-type E3 ubiquitin transferase
(23)
Biological function
(11)
protein binding
(13)
ubiquitin protein ligase activity
(13)
ubiquitin-protein transferase activity
(13)
metal ion binding
(11)
zinc ion binding
(11)
transcription coactivator activity
(9)
transferase activity
(9)
carbohydrate transmembrane transporter activity
(4)
DNA binding
(2)
PDZ domain binding
(2)
maltose binding
(2)
Biological process
(40)
protein polyubiquitination
(13)
androgen receptor signaling pathway
(9)
brain development
(9)
modulation of chemical synaptic transmission
(9)
negative regulation of TORC1 signaling
(9)
ovarian follicle development
(9)
positive regulation of Golgi lumen acidification
(9)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
(9)
positive regulation of protein ubiquitination
(9)
positive regulation of transcription by RNA polymerase II
(9)
progesterone receptor signaling pathway
(9)
prostate gland growth
(9)
proteasome-mediated ubiquitin-dependent protein catabolic process
(9)
protein K48-linked ubiquitination
(9)
protein autoubiquitination
(9)
protein ubiquitination
(9)
proteolysis
(9)
regulation of circadian rhythm
(9)
regulation of synaptic plasticity
(9)
regulation of ubiquitin-dependent protein catabolic process
(9)
response to progesterone
(9)
rhythmic process
(9)
sperm entry
(9)
ubiquitin-dependent protein catabolic process
(9)
carbohydrate transport
(4)
transmembrane transport
(4)
DNA damage response
(2)
DNA-templated transcription
(2)
carbohydrate transmembrane transport
(2)
cell chemotaxis
(2)
detection of maltose stimulus
(2)
maltodextrin transmembrane transport
(2)
maltose transport
(2)
regulation of DNA-templated transcription
(2)
symbiont-mediated perturbation of host apoptosis
(2)
symbiont-mediated perturbation of host ubiquitin-like protein modification
(2)
symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity
(2)
symbiont-mediated suppression of host innate immune response
(2)
symbiont-mediated suppression of host type I interferon-mediated signaling pathway
(2)
negative regulation of DNA-templated transcription
(1)
Biological cell component
(15)
cytoplasm
(9)
cytosol
(9)
glutamatergic synapse
(9)
nucleus
(9)
postsynaptic cytosol
(9)
proteasome complex
(9)
synaptic vesicle
(9)
ATP-binding cassette (ABC) transporter complex
(2)
ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing
(2)
host cell cytoplasm
(2)
host cell nucleus
(2)
maltose transport complex
(2)
membrane
(2)
outer membrane-bounded periplasmic space
(2)
periplasmic space
(2)
Sequence and Structure classification
SCOP fold
(2)
Hect, E3 ligase catalytic domain
(2)
Papillomavirus e6-interacting peptide of e6ap
(1)
SCOP family
(2)
Hect, E3 ligase catalytic domain
(2)
Papillomavirus e6-interacting peptide of e6ap
(1)
CATH class
(2)
Alpha Beta
(3)
Special
(1)
CATH topology
(5)
Hect, E3 ligase catalytic domain
(2)
Hect, E3 ligase catalytic domain fold
(2)
Hect, E3 ligase catalytic fold
(2)
D-Maltodextrin-Binding Protein; domain 2
(1)
GTP Cyclohydrolase I; Chain A, domain 1
(1)
Pfam accession / name
(4)
PF00632 : HECT
(13)
PF16558 : AZUL
(13)
PF01547 : SBP_bac_1
(3)
PF00518 : E6
(2)
Experimental Information
Diffraction protocol
(1)
Single wavelength
(9)
Diffraction radiation source type
(2)
Synchrotron
(9)
Rotating anode
(1)
Diffraction source
(7)
SLS BEAMLINE X06DA
(4)
ALS BEAMLINE 5.0.2
(1)
BESSY BEAMLINE 14.1
(1)
ESRF BEAMLINE ID14-4
(1)
ESRF BEAMLINE ID23-1
(1)
NSLS BEAMLINE X4A
(1)
RIGAKU RU200
(1)
Synchrotron site
(5)
SLS
(4)
ESRF
(2)
ALS
(1)
BESSY
(1)
NSLS
(1)
Diffraction detector type
(3)
Pixel
(6)
CCD
(3)
Image plate
(1)
Refinement software
(5)
PHENIX
(6)
CNS
(2)
BUSTER
(1)
REFMAC
(1)
phenix.real_space_refine
(1)
EM microscope model
(2)
FEI TITAN KRIOS
(7)
TFS GLACIOS
(2)
EM detector name
(2)
GATAN K3 (6k x 4k)
(6)
FEI FALCON IV (4k x 4k)
(3)
NMR
NMR software packages
(12)
NMRPipe
(4)
TALOS
(4)
CNS
(3)
CYANA
(3)
NMRFAM-SPARKY
(2)
FMC
(1)
PROCHECK / PROCHECK-NMR
(1)
Sparky
(1)
TopSpin
(1)
X-PLOR
(1)
XEASY
(1)
Xplor-NIH
(1)
NMR Field Strength
400.0 - 500
(1)
500.0 - 600
(3)
600.0 - 700
(2)
700.0 - 800
(3)
800.0 - 900
(3)
Entries
Macromolecules
Compounds
Protein families
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