NS
NS as an abbreviation can mean:
Geography
Government and politics
Commerce
Kingdom of Loathing
Kingdom of Loathing (abbreviated KoL) is a browser-based, multiplayer role-playing game designed and operated by Asymmetric Publications, including creator Zack "Jick" Johnson and writer Josh "Mr Skullhead" Nite. The game was released in 2003. Because content is added frequently, the game is considered unfinished and officially remains in open beta.
It uses hand-drawn stick figure graphics and writing characterized by surreal humor, word play, parody and references to popular culture. In KoL, a player's character fights monsters for experience, and acquiring meat (the game's currency), and/or items, through a turn-based system. Players may also interact with each other through player versus player competition, participate in the in-game economy by trading goods and services, organize their characters into clans, work together to complete clan dungeons, and speak to each other in many different chat channels.
The game is also particularly notable for managing to be financially successful purely from donations and the purchase of merchandise rather than from advertising or subscription fees, which are used by many online games. In 2008, the game had between 100,000 and 150,000 regular players. These players form an active community which frequently organizes fan meet-ups and runs an internet radio station. The game has been generally well received by critics. In 2012, Mr. Card Game, a tabletop game based on Kingdom of Loathing, was launched on Kickstarter.
Nudelman-Suranov NS-23
The NS-23 was a 23 mm (0.91 in) aircraft cannon designed by A. E. Nudelman, A. Suranov, G. Zhirnykh, V. Nemenov, S. Lunin, and M. Bundin during World War II as a replacement for the Volkov-Yartsev VYa-23 cannon. It entered service in 1944. The NS-23 round was derived from the 14.5×114mm anti-tank round by necking it out to 23 mm.
A synchronized version, designated NS-23S (S for synchronized), was used for fixed installations firing through the propeller disc.
Applications of the NS-23 included the Antonov An-2, Ilyushin Il-10, Ilyushin Il-22, Lavochkin La-9, La-15, MiG-9, Yak-9UT, Yak-15, Yak-17, and Yak-23. Some early MiG-15s also were equipped the NS-23.
The NS-23 was replaced in service by the Nudelman-Rikhter NR-23 around 1949.
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Tesofensine
Tesofensine (NS2330) is a serotonin–noradrenaline–dopamine reuptake inhibitor from the phenyltropane family of drugs, which is being developed for the treatment of obesity. Tesofensine was originally developed by a Danish biotechnology company, NeuroSearch, who transferred the rights to Saniona in 2014.
As of 2015, tesofensine has been discontinued for the treatment of obesity.
History
Tesofensine was originally investigated for the treatment of Alzheimer's disease and Parkinson's disease, and was subsequently dropped from development for these applications after early trial results showed limited efficacy for treatment of these diseases. However, weight loss was consistently reported as an adverse event in the original studies, especially in overweight or obese patients. Therefore, it was decided to pursue development of tesofensine for the treatment of obesity.
Tesofensine primarily acts as an appetite suppressant, but possibly also acts by increasing resting energy expenditure.Phase 2 trials for the treatment of obesity have been successfully completed.
NS-2710
NS-2710 (LS-193,970) is an anxiolytic drug with a novel chemical structure, developed by the small pharmaceutical company Neurosearch. It has similar effects to benzodiazepine drugs, but is structurally distinct and so is classed as a nonbenzodiazepine anxiolytic. NS-2710 is a potent but non-selective partial agonist at GABAA receptors, although with little efficacy at the α1 subtype and more at α2 and α3. It has anxiolytic effects comparable to chlordiazepoxide, and while it is a less potent anticonvulsant than the related drug NS-2664, it has a much longer duration of action, and similarly to other α2/α3-preferring partial agonists produces little sedative effects or physical dependence.
References
Yamaha NS-10
The Yamaha NS-10 is a loudspeaker that became a standard nearfield studio monitor in the music industry among rock and pop recording engineers. Launched in 1978, the NS-10 started life as a bookshelf speaker destined for the domestic environment. It was poorly received but eventually became a valuable tool with which to mix rock recordings. The speaker has a characteristic white-coloured mid–bass drive unit.
Technically, it is known as a speaker that easily reveals poor quality in recordings. Recording engineers sought to dull its treble response by hanging tissue paper in front of it, resulting in what became known as the "tissue paper effect", a type of comb filtering. The NS-10 has been used to monitor a large number of successful recordings by numerous artists, leading Gizmodo to refer to it as "the most important loudspeaker you never heard of". Yamaha discontinued the product in 2001.
History
Originally conceived as a domestic hi-fi speaker, the NS-10 was designed by Akira Nakamura and launched in 1978. It was sold at the $400 price point. The speaker was poorly received and its commercial life was short. However, it took five years for its popularity to be established with professional users. As recording engineers came to rely on the NS-10 as a benchmark, it dominated the mixing of pop and rock music throughout the world for at least 20 years.
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