MCL1
Induced myeloid leukemia cell differentiation protein Mcl-1 is a protein that in humans is encoded by the MCL1 gene.
Function
The protein encoded by this gene belongs to the Bcl-2 family. Alternative splicing occurs at this locus and two transcript variants encoding distinct isoforms have been identified. The longer gene product (isoform 1) enhances cell survival by inhibiting apoptosis while the alternatively spliced shorter gene product (isoform 2) promotes apoptosis and is death-inducing.
Clinical significance
Omacetaxine mepesuccinate and Seliciclib as an investigational treatment for chronic myelogenous leukemia (CML) and multiple myeloma respectively, act by inhibiting synthesis of Mcl-1.
Interactions
MCL1 has been shown to interact with:
BAK1,
BCL2L11,
BID,
BAD,
DAD1,
PMAIP1,
PCNA, and
TNKS
See also
Bcl-2
Bcl-xL
References
Further reading