Maoča (Srebrenik)

Maoča is a village in Bosnia and Herzegovina. According to the 1991 census, the village is located in the municipality of Srebrenik.

References

Coordinates: 44°43′44″N 18°37′40″E / 44.72889°N 18.62778°E / 44.72889; 18.62778

Maoča, Brčko

Maoča (Serbian: Маоча) is a village in the municipality of Brčko, Bosnia and Herzegovina.

References

Coordinates: 44°46′06″N 18°39′25″E / 44.76833°N 18.65694°E / 44.76833; 18.65694

Monoamine oxidase A

Monoamine oxidase A, also known as MAO-A, is an enzyme that in humans is encoded by the MAOA gene. This gene is one of two neighboring gene family members that encode mitochondrial enzymes which catalyze the oxidative deamination of amines, such as dopamine, norepinephrine, and serotonin. Mutation of this gene results in Brunner syndrome. This gene has also been associated with a variety of other psychiatric disorders, including antisocial behavior. Alternatively spliced transcript variants encoding multiple isoforms have been observed.

Structure

Gene

The promoter of MAOA contains conserved binding sites for Sp1, GATA2, and TBP. This gene is adjacent to a related gene (MAOB) on the opposite strand of the X chromosome.

Protein

This gene encodes a monomeric protein which shares a 70% amino acid sequence identity, as well as conserved chain folds and flavin adenine dinucleotide (FAD)-binding site structures, with MAO-B. However, MAO-A has a monopartite cavity of approximately 550 angstroms, compared to the 290-angstrom bipartite cavity in MAO-B. Nonetheless, both proteins adopt dimeric forms when membrane-bound. The C-terminal domain of MAO-A forms helical tails which are responsible for attaching the protein to the outer mitochondrial membrane (OMM). MAO-A contains loop structures at the entrance of its active site.