Gardner's syndrome

Gardner syndrome, also known as familial colorectal polyposis, is an autosomal dominant form of polyposis characterized by the presence of multiple polyps in the colon together with tumors outside the colon. The extracolonic tumors may include osteomas of the skull, thyroid cancer, epidermoid cysts, fibromas, as well as the occurrence of desmoid tumors in approximately 15% of affected individuals.

Desmoid tumors are fibrous tumors which usually occur in the tissue covering the intestines and may be provoked by surgery to remove the colon. The countless polyps in the colon predispose to the development of colon cancer; if the colon is not removed, the chance of colon cancer is considered to be very significant. Polyps may also grow in the stomach, duodenum, spleen, kidneys, liver, mesentery and small bowel. In a small number of cases, polyps have also appeared in the cerebellum. Cancers related to GS commonly appear in the thyroid, liver and kidneys. The number of polyps increases with age, and hundreds to thousands of polyps can develop in the colon.

Gardners Books

Gardners Books is the largest book wholesaler in the United Kingdom. Based in Eastbourne, East Sussex, Gardners supplies books to a number of British retailers including Waterstone's, Tesco.com Books, TheHut.com, The Book Depository and WHSmith. They have a stock catalogue of over 850,000 titles from over 4,000 publishers, with around 400,000 in stock at any one time.

Gardners provide an automated telephone enquiry line known as GardCall which gives availability of a book from an ISBN. Gardners also provide support for EPOS ordering systems.

In October 2008, Gardners moved into the DVD market and in 2010 moved into the CD market.

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