JAG1

Jagged1 (JAG1) is one of five cell surface proteins (ligands) that interact with 4 receptors in the mammalian Notch signaling pathway. The Notch Signaling Pathway is a highly conserved pathway that functions to establish and regulate cell fate decisions in many organ systems. Once the JAG1-NOTCH (receptor-ligand) interactions take place, a cascade of proteolytic cleavages is triggered resulting in activation of the transcription for downstream target genes. Located on human chromosome 20, the JAG1 gene is expressed in multiple organ systems in the body and causes the autosomal dominant disorder Alagille syndrome (ALGS) resulting from loss of function mutations within the gene. JAG1 has also been designated as CD339 (cluster of differentiation 339).

Structure and function

JAG1 was first identified as a ligand that was able to activate notch receptors when it was cloned in the mammalian rat in 1995. It is located at cytogenetic location 20p12.2 and genomic location (GRCh37) chr20:10,618,331-10,654,693 on the human chromosome 20. The structure of the JAG1 protein includes a small intracellular component, a transmembrane motif, proceeded by an extracellular region containing a cystine-rich region, 16 EGF-like repeats, a DSL domain, and finally a signal peptide totaling 1218 amino acids in length over 26 coding exons.

JAG (band)

JAG was a Christian rock band that recorded during the early 1990s. The band's name is an acronym for the band's founder and lead singer, John Allen Garies.

John "Johnny" Allen Garies, Jr. (November 11, 1952 – August 5, 2007) was born in Houston, TX to John A. “Oscar” Garies, Sr. and Shirley A. (Gray) Garies, one of three children (Michael and Wendy, his two siblings). Garies started playing drums at age 10 and taught himself to play guitar and piano. Graduating in 1971 from Channelview High School in Harris County, Texas, John attended Texas A&M University. He married his wife, Ricka Cox around 1973, with whom he had two children, John Joel and Annie Grace.

Building on his passion for music, Garies formed JAG in the late 1980s. JAG's original lineup for their 1990 debut, The Longest Road included guitarist J. Paul Brittain, bassist Tim Hall, drummer Chuck Connor, and Garies on lead vocals. Their 1991 follow up The Only World In Town traded McCreight for Michael Lusk and featured additional help from drummer Chris McHugh and guitarists, Jim Williams, Dale Oliver (originally of Geoff Moore's band) and Giant's Dann Huff. Produced by frequent CCM-session keyboardist Blair Masters, JAG's final album, Fire in the Temple, featured songs written by Garies, and the likes of Billy Smiley and Mark Gersmehl and performed by players Gordon Kennedy, Chris McHugh and Tommy Sims, all of whom were current or former members of the group Whiteheart, a band's sound to which JAG is oft-compared.

List of JAG episodes

JAG (U.S. military acronym for Judge Advocate General) is an American legal drama television show with a distinct U.S. Navy theme, created by Donald P. Bellisario, and produced by Belisarius Productions in association with Paramount Network Television (now CBS Television Studios). The first season was co-produced with NBC Productions.

Originally perceived as a Top Gun meets A Few Good Men hybrid series, the pilot episode of JAG first aired on NBC on September 23, 1995, but the series was later canceled on May 22, 1996, after finishing 79th in the ratings, leaving one episode unaired. Rival network CBS picked up the series for a midseason replacement, beginning on January 3, 1997. For several seasons, JAG climbed in the ratings and was on the air for nine additional seasons. JAG furthermore spawned the hit series NCIS, which in turn spun off NCIS: Los Angeles and NCIS: New Orleans.

In total, 227 episodes were produced over 10 seasons. At the time of the original airing of its fifth season in the United States, JAG was seen in over 90 countries worldwide.JAG entered syndication early in 1999.

Borș

Borş can refer to:

Bór railway station

Bór is a former PKP railway station in Hel (Pomeranian Voivodeship), Poland. The station was used for military base service.

Lines crossing the station

References

Coordinates: 54°39′N 18°47′E / 54.650°N 18.783°E / 54.650; 18.783

Bor, Serbia

Bor (Serbian Cyrillic: Бор) is a town and municipality located in eastern Serbia, with one of the largest copper mines in Europe - RTB Bor. It has been a mining center since 1904, when a French company began operations there. It is the administrative center of the Bor District of Serbia. The population of the town is 34,160, while municipality has 48,615.

Name

The name is derived from the Serbian word Bor (Бор), meaning "pine".

Geography

Bor is surrounded by many beautiful places such as Banjsko Polje, the spa-town Brestovačka Banja, the lake Borsko Jezero, and the mountain Stol, and it is very close to the mountain Crni Vrh.

History

Neolithic Bubanj-Salkuca culture ceramics and anthropomorphic-zoomorphic figurines were found in Krivelj.

In 1903 the mine of Bor was opened which was important moment for the development of Bor. The poet Miklós Radnóti wrote here some of the most beautiful poems ever written in Hungarian during his forced labour (1944) in the copper mines.

In 1947 Bor officially had a town status - at the time its population was 11,000.

Linn

Linn is a first name for girls. This name is common in countries such as Sweden and Norway. Otherwise it can also be spelled "Lynn". Linn may refer to:

Linn (surname)

Place names

Other