The Spring 2012 season of CACAO has started!
cyclooxygenase
Two izoenzymes of cyclooxygenase, COX-1 and COX-2, are proven to catalyze the rate-limiting step in prostaglandin synthesis. This enzyme is the target of nonsteroidal anti-inflammatory drugs, mainly Acetaminophen.
Cyclooxygenase-2, COX-2, is overexpressed in colon cancer, suggesting a relationship between the pathway and signaling of COX-2 and colorectal carcinogens. When COX-2 activity is inhibited by sulindac, a metabolite of sulindac sulfoxide, the average diameter and number of polyps decreased in patients affected by colorectal cancers.
See also
The role of cyclooxygenase-2 in Colon Cancer. [1]
COX-3: Cloning, Structure, and Expression [2]
Variants of cyclooxygenase-1 and their roles in medicine. [3]
References
See Help:References for how to manage references in GONUTS.
- ↑ Eisinger AL et al. (2007) The role of cyclooxygenase-2 and prostaglandins in colon cancer. Prostaglandins Other Lipid Mediat 82: 147-54 PubMed GONUTS page
- ↑ Chandrasekharan NV et al. (2002) COX-3, a cyclooxygenase-1 variant inhibited by acetaminophen and other analgesic/antipyretic drugs: cloning, structure, and expression. Proc Natl Acad Sci U S A 99: 13926-31 PubMed GONUTS page
- ↑ Simmons DL (2003) Variants of cyclooxygenase-1 and their roles in medicine. Thromb Res 110: 265-8 PubMed GONUTS page
