Jordan Lane

A major step in the right direction to unlock the promise of the human #genome help patients with common #complex AND #rare #neurodegenerative, #immunological and #cardiovascular diseases and #cancer improving #diagnosis, #prognosis and #prediction of #therapy #outcome with endless opportunities to identify novel drug targets and support the repositioning of existing drugs! Great news for patients and families alike! #patientsarewaiting #plasma #proteomics #genomics #proteogenomics #UKBB Olink Proteomics Ultima Genomics

11

I want to share the new Imperial College London and UCL collaborative research preprint I co-authored that might be of interest, especially if you're fascinated by how cells work (and sometimes, how they stop working!). Our paper, "Functional analyses and integrated mechanisms of cellular destruction by L-amino acid oxidase" go into the world of an enzyme called L-amino acid oxidase (LAAO). Think of LAAO as a tiny but powerful worker inside cells that can trigger cell death under certain conditions. Here's the gist in simple terms: LAAO is an enzyme that breaks down amino acids. This process produces hydrogen peroxide, a molecule that can be damaging to cells in high amounts. We studied how LAAO causes cell death. We found that it's not just about the hydrogen peroxide. LAAO also messes with other important cellular processes, like the mitochondria (the cell's powerhouses) and the cell's internal structure. We used some cool technology to see all this in action! The Opera Phenix from Revvity let us take amazing images of cells and see exactly what LAAO was doing inside them. Why is this important? Understanding how enzymes like LAAO work can help us learn more about diseases where cell death goes wrong, like in cancer or neurodegenerative disorders. If you're curious to learn more, check out the full preprint here: https://lnkd.in/eunq8_Tj This project used Thermo Fisher Scientific essential reagents and experimental tools, Cytiva for high-performance chromatography solutions and Sigma-Aldrich Production GmbH chemical products. #cellbiology #LAAO #enzymes #celldeath #apoptosis #mitochondria #undergraduateresearch #science #biochemistry #preprint #Revvity #OperaPhenix

17

2 Comments

Exploring RAS and RAF Target Engagement: Live-Cell Insights into Molecular Specificity 🔎 Check out a new #PromegaNotes article to discover advanced assay technologies, such as live-cell #NanoBRET® TE Intracellular Assays, reshaping the landscape of drug discovery methods and offering biologically relevant models for enhanced research. https://bit.ly/3zEFa3O #CancerResearch #oncology #lifescience

3

40% of people receiving targeted chemotherapy are hospitalised by the side effects. We've started Siftr Bio to change this. 🎯 Backed by US investors Endeavor8, Wilbe, and Cancer Research UK (CRUK), we focus on precision therapies that activate specifically in tumors with minimal side effects. 🙏 Supportive groups in academic institutions are key to enable spinouts such as Siftr to actually get off the ground - particular thanks go to Anna Barnard, Ed Tate, and Aidan Pidd for their encouragement and support. Finally, thanks to BioIndustry Association (BIA) , Pioneer Group and Cancer Tech Accelerator for their programmes. 🔎 To learn more about what we're building, check out Siftr Bio.

124

3 Comments

Revolutionising Long Covid Diagnosis: A Groundbreaking Discovery by Attomarker Milltrust International is excited to share an enlightening discussion with Professor Andrew Shaw from the University of Exeter, showcasing a transformative diagnostic test developed by Attomarker, one of our portfolio companies within the One Health Fund. This innovation could significantly change the way we diagnose and treat Long Covid. Professor Shaw, a distinguished physical chemist with over 20 years of experience in immunity testing and antibodies, reveals how a simple finger prick blood test can detect gaps in a patient’s antibody spectrum. These gaps highlight the specific Covid-19 variants to which a patient had an insufficient antibody response, potentially causing the chronic symptoms of Long Covid. How It Works: • Identifies antibody gaps indicating specific Covid-19 variants. • Enables targeted treatment with monoclonal antibodies or appropriate vaccines. • Helps patients combat the lingering effects of the virus. Early-stage results are promising, and Attomarker is currently seeking funding for full-scale trials. Professor Shaw shares a compelling story of one patient’s significant recovery using this innovative approach. Highlights of the Episode: • Intricate theories of antibody responses to Covid-19 strains. • The impact of vaccines. • The potential of the Attomarker test as a diagnostic tool and effective treatment strategy for Long Covid. This breakthrough could be pivotal in managing and overcoming the long-term impacts of the pandemic. What are your thoughts on the potential of antibody testing to transform healthcare? #LongCovid #Innovation #MedicalBreakthrough #Healthcare #AntibodyTesting #Covid19 #Vaccines #Attomarker #Milltrust #OneHealthFund Simon Hopkins CELINE L. Henry S. Andrew Shaw Alexander Kalis Jonathan Snicker Raman Chandrasekar

10

This is probably the most amazing PhD research project in the entirety of the European continent. It deals with the enhancement of the intensity of the light from an external source at the surface of gold nanorods. In this way, the incident photons are absorbed by the plasmons at the surface of the gold nanorods creating a localized plasmon resonant oscillation and amplifying the intensity of the light electromagnetic field several orders of magnitude within the near field. By virtue of the antenna effect of said gold nanorods, the weak intensity of the light originating from an external source could be boosted at least three orders of magnitude deep in the brain. Thus delivering therapeutic doses of light in a minimally invasive way. Opportunity available now for one lucky student at the University of Birmingham.   https://lnkd.in/eqzGpriZ

7

2 Comments

#STORM's Vice President Medicinal Chemistry, Beth Thomas, is presenting at the Society for Medicines Research's 'Modulating RNA with oligonucleotides or small molecules' conference today!   Beth will be presenting from 13.50 - 14.30 BST on the 'Discovery of STC15, the First Molecule Specifically Targeting an RNA Methyltransferase Enzyme to Enter Clinical Development'.   The one-day conference brings together speakers who will explore successful approaches, future opportunities, and novel approaches being explored in industry and academia to exploit ways to downregulate, upregulate or change splicing in protein synthesis for therapeutic purposes.   #lifesciences #biotech #drugdiscovery #research #STC15 #METTL3 #METTL1 #RNA #modification

87

2 Comments

Want to design proteins that interact and use them to advance cell imaging and understanding of biological systems including disease? Apply for the the PhD studentship in the link below supervised by myself, Richard Clarkson, Georgina Menzies and Peter Watson

20

Here, our team Candesic write about the rise of #robots in the #pharma industry. With my colleague Dr Leonid Shapiro, I explore how pharma is investing large amounts of money in robots to improve efficiency. https://lnkd.in/e7BR3isi #lifesciences #robotics #AI #pharmaceuticalindustry #healthcare #manufacturing

9

🤝🏻 We have successfully completed our collaboration with the Welch research group at The Babraham Institute to evaluate lead compounds predicted to bind a pro-inflammatory protein identified in our pilot studies. The project was funded by the UKRI-BBSRC Campus Innovation Award (CIA), via the Babraham Research Campus Collaboration Fund in October 2023. The collaboration demonstrates that new disease-specific targets identified in our trial have the potential to be modifiable by small molecule drugs—opening new opportunities for a precision medicine approach to heart disease. We are now evaluating the target in our ongoing BIOPATTERN trial and, if validated, further development will be pursued. Read more ➡ https://rb.gy/6b1o61 #CoronaryArteryDisease #Collaboration #ClinicalTrial #PrecisionMedicine #HeartDisease

29

3 Comments

A must-read for anyone working in genetic medicine. Salveen Richter asks a key question - and I respectfully submit that there is a 4th solution and it involves developing and clinically deploying a fundamentally new way to design/built/clinically test all-nonviral CRISPR for genetic disease. Watch this space. https://lnkd.in/gsMjAaTq

72

17 Comments

AMLo Biosciences CSO Penny Lovat has just given a lecture on AMBLor at the prestigious St John's DermAcademy Society Meeting. Her talk described the discovery and validation studies and concluded with the e-Delphi survey which shows that using AMBLor in early stage melanomas will change clinical decision making about employing Sentinel Lymph Node Biopsies and use of adjuvant immunotherapy in Stage IIB melanoma.

20

Come to join us to learn all the tips and tricks to optimise your spectral workflow!

5

Whole plasmid sequencing using short read from Illumina and long reads from Oxford Nanopore Technologies has the potential to streamline the quality control of plasmids used in #biotechnology and #lifescience. Casey-Tyler Berezin, PhD and Sarah Hernandez led an effort to evaluate the reproducibility of plasmid sequencing workflows. Some commonly used plasmids are surprisingly challenging to sequence, even when using a hybrid assembly strategy that combines long and short reads. Read the preprint at https://lnkd.in/e6VireeS Contact me if you need help verifying your plasmids. #lablife #synbio #syntheticbiology #reproducibility #biology #molecularbiology

19

Exciting Breakthrough in IBD Research Employing Human Tissue Assays! A recent discovery by scientists at The Francis Crick Institute and University College London has unveiled a significant genetic factor contributing to inflammatory bowel disease (IBD). This groundbreaking research in functional genomics identifies a weak spot in DNA that affects the behaviour of macrophages, leading to excessive inflammation in the bowels. With Crohn’s disease and ulcerative colitis affecting millions globally, this finding marks a pivotal step towards understanding and potentially curing IBD. At REPROCELL, we are at the forefront of drug discovery, and this research aligns perfectly with our mission, by combining genomics with pharmacology. Our advanced assays, including those specifically for IBD, are designed to identify and develop targeted treatments that address the root causes of diseases. The identification of a key “regulator” gene of inflammation opens new avenues for creating more effective and personalized therapies. Using tests in ex vivo tissues from patients with IBD (as routinely done by REPROCELL), the research team found that certain existing drugs can reverse excessive inflammation, providing a head start toward developing new treatments. However, challenges remain in targeting these treatments precisely to avoid side effects and ensure they do not impair beneficial inflammation. We are excited to see such progress in the field and are committed to contributing to these advancements as we move closer to a world free from the debilitating impacts of IBD. Check out our IBD assay here: https://lnkd.in/eDhPDbUh Read more about the breakthrough in the BBC article: https://lnkd.in/e3QJ3FFb REPROCELL’s paper on functional genomics using human tissue and the use of machine learning in IBD research: https://lnkd.in/daRW7yM9

9

Discover how the BOW Project fuses nanotechnology and biology to create transformative nanomedicine solutions that are revolutionising healthcare. #Nanomedicine #Nanotechnology #Healthcare #Biology https://bit.ly/3UuPnrK

6

The future might be decentralised science, learn all about the how and why in this latest issue alongside two brilliant interviews and our regular features. Read the latest issue! ➡️ https://lnkd.in/e86BnYbt #labhorizons #science #scimag #magazine #research #academics #ai #ml

3

The future might be decentralised science, learn all about the how and why in this latest issue alongside two brilliant interviews and our regular features. Read the latest issue! ➡️ https://lnkd.in/e86BnYbt #labhorizons #science #scimag #magazine #research #academics #ai #ml

1