“During my time working with Dael we successfully led the largest transformation in digital. A trusted partner with excellent technology, business and architecture skills. Dael’s team engagement, communication and passion for digital technology helped drive our change agenda.”
About
I am a British citizen, born in the Zimbabwean bush and educated in South Africa…
Activity
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🚀🚀 Day 2 of Data Intelligence Week 🚀🚀 Here's a recap of the Databricks and AtScale partnership from inception until today. It also contains a…
🚀🚀 Day 2 of Data Intelligence Week 🚀🚀 Here's a recap of the Databricks and AtScale partnership from inception until today. It also contains a…
Liked by Dael Williamson
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Last Thursday, Databricks had the pleasure of sponsoring and participating in Quantexa's annual conference #QuanCon25! It's great to see how…
Last Thursday, Databricks had the pleasure of sponsoring and participating in Quantexa's annual conference #QuanCon25! It's great to see how…
Liked by Dael Williamson
Experience
Education
Licenses & Certifications
Publications
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Conversion of Sterically Demanding a,a-Distributed Phenylacetonitriles by the Arylacetonitrilase from Pseudomonas fluorescens EBC191
Applied and Environmental Microbiology
The nitrilase from Pseudomonas fluorescens EBC191 converted 2-methyl-2-phenylpropionitrile, which contains a quaternary carbon atom in the α-position toward the nitrile group, and also similar sterically demanding substrates, such as 2-hydroxy-2-phenylpropionitrile (acetophenone cyanohydrin) or 2-acetyloxy-2-methylphenylacetonitrile. 2-Methyl-2-phenylpropionitrile was hydrolyzed to almost stoichiometric amounts of the corresponding acid. Acetophenone cyanohydrin was transformed to the…
The nitrilase from Pseudomonas fluorescens EBC191 converted 2-methyl-2-phenylpropionitrile, which contains a quaternary carbon atom in the α-position toward the nitrile group, and also similar sterically demanding substrates, such as 2-hydroxy-2-phenylpropionitrile (acetophenone cyanohydrin) or 2-acetyloxy-2-methylphenylacetonitrile. 2-Methyl-2-phenylpropionitrile was hydrolyzed to almost stoichiometric amounts of the corresponding acid. Acetophenone cyanohydrin was transformed to the corresponding acid (atrolactate) and amide (atrolactamide) at a ratio of about 3.4:1. The (R)-acid and the (S)-amide were formed preferentially from acetophenone cyanohydrin. A homology model of the nitrilase suggested that steric hindrance with amino acid residue Tyr54 could impair the binding or conversion of sterically demanding substrates. Therefore, several enzyme variants that carried mutations in the respective residues were generated and subsequently analyzed for the substrate specificity and enantioselectivity of the reactions. Enzyme variants that demonstrated increased relative activities for the conversion of acetophenone cyanohydrin were identified. The chiral analysis of these reactions demonstrated peculiar reaction kinetics, which suggested that the enzyme variants converted the nonpreferred (S)-enantiomer of acetophenone cyanohydrin with a higher reaction rate than that of the (preferred) (R)-enantiomer. Recombinant whole-cell catalysts that simultaneously produced the nitrilase from P. fluorescens EBC191 and a plant-derived (S)-oxynitrilase from cassava (Manihot esculenta) converted acetophenone plus cyanide at pH 4.5 to (S)-atrolactate and (S)-atrolactamide. These recombinant cells are promising catalysts for the synthesis of stable chiral quaternary carbon centers from ketones.
Other authors -
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Structural and biochemical characterization of a nitrilase from the thermophilic bacterium, Geobacillus pallidus RAPc8.
Appl Microbiology and Biotechnology.
Geobacillus pallidus RAPc8 (NRRL: B-59396) is a moderately thermophilic gram-positive bacterium, originally isolated from Australian lake sediment. The G. pallidus RAPc8 gene encoding an inducible nitrilase was located and cloned using degenerate primers coding for well-conserved nitrilase sequences, coupled with inverse PCR. The nitrilase open reading frame was cloned into an expression plasmid and the expressed recombinant enzyme purified and characterized. The protein had a monomer molecular…
Geobacillus pallidus RAPc8 (NRRL: B-59396) is a moderately thermophilic gram-positive bacterium, originally isolated from Australian lake sediment. The G. pallidus RAPc8 gene encoding an inducible nitrilase was located and cloned using degenerate primers coding for well-conserved nitrilase sequences, coupled with inverse PCR. The nitrilase open reading frame was cloned into an expression plasmid and the expressed recombinant enzyme purified and characterized. The protein had a monomer molecular weight of 35,790 Da, and the purified functional enzyme had an apparent molecular weight of ~600 kDa by size exclusion chromatography. Similar to several plant nitrilases and some bacterial nitrilases, the recombinant G. pallidus RAPc8 enzyme produced both acid and amide products from nitrile substrates. The ratios of acid to amide produced from the substrates we tested are significantly different to those reported for other enzymes, and this has implications for our understanding of the mechanism of the nitrilases which may assist with rational design of these enzymes. Electron microscopy and image classification showed complexes having crescent-like, “c-shaped”, circular and “figure-8” shapes. Protein models suggested that the various complexes were composed of 6, 8, 10 and 20 subunits, respectively.
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Projects
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World Health Data Hub for WHO & Country Health Data Hubs
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Global data and technology governance on a global healthcare data hub platform with the WHO (Global level) and a country national data hub platform (Member State level). Aim to construct a reusable healthcare industry platform focused on data product thinking while at the same time considering ways to create a highly secure data organisation with a data marketplace for various data consumers (e.g. global researchers & health policy makers). Application of data mesh and lake house thinking to…
Global data and technology governance on a global healthcare data hub platform with the WHO (Global level) and a country national data hub platform (Member State level). Aim to construct a reusable healthcare industry platform focused on data product thinking while at the same time considering ways to create a highly secure data organisation with a data marketplace for various data consumers (e.g. global researchers & health policy makers). Application of data mesh and lake house thinking to productise data for public services reuse.
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Innovation Consulting: creating a design-driven business in leading Chemicals & Energy company
Over 6 days we ran 9x innovation workshop sessions with the Sasol IT leadership team to familiarise them with the principles of Design Thinking, and to apply the techniques to empathetically unearth and identify both strategic transformation and innovation idea opportunities. The process was aimed at:
1. Seeding a design driven mindset into the Sasol Leadership
2. Enable IT business unit to transition from support function to strategic enabler for change & reinvention
3. Advise on…Over 6 days we ran 9x innovation workshop sessions with the Sasol IT leadership team to familiarise them with the principles of Design Thinking, and to apply the techniques to empathetically unearth and identify both strategic transformation and innovation idea opportunities. The process was aimed at:
1. Seeding a design driven mindset into the Sasol Leadership
2. Enable IT business unit to transition from support function to strategic enabler for change & reinvention
3. Advise on the Sasol strategic roadmap and innovation opportunities using insights and needs observedOther creators -
Virgin Active Red - a new low cost, high tech health club for the SA market
My role was technology lead, working with the COO of Red and the Ops PMO to design & deliver a technology journey for a new low cost health club for the SA market.
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London Olympics: BT Telecoms Infrastructure.
Ran a team of DevOps and software engineers to support BT's Cisco telecom infrastructure during 2012 games.
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Enterprise Risk Data Strategy for Global Investment Bank
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Crafted and governance of a 5-year global data transformation strategy for Enterprise Risk & Finance to align data strategy to business model allowing business to meet regulatory requirements; understand risk across products and business units; modernise and standardise technology; and reduce data duplication across the group.
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Data-driven operations decision making for Materials Services
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A cloud-based platform that could automatically analyse organisational data and run simulations based on operational hypotheses - the solution that would come to be known as alfred.simOne.
The power of the tool lies in its ability to run simulations – based on inputted network configurations – that process large amounts of data and intelligently analyse the results to see the impact on transportation costs and inventory levels. In one test simulation during the development phase, it was…A cloud-based platform that could automatically analyse organisational data and run simulations based on operational hypotheses - the solution that would come to be known as alfred.simOne.
The power of the tool lies in its ability to run simulations – based on inputted network configurations – that process large amounts of data and intelligently analyse the results to see the impact on transportation costs and inventory levels. In one test simulation during the development phase, it was discovered that centralising a single product to a smaller group of sites could save half a million euros per year without sacrificing service.
Platform is playing a catalytic role in tranforming the organisation into a data-driven business. -
UK Insurance company: High volume pricing engine for online pricing optimisation
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High volume data processing and pricing engine to provide Pricing Data Scientists an environment for developing Omnichannel Pricing Models to drive conversion of Travel & Home products on aggregator and own channels.
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Intelligent Case & Fault Breakdown Management for Large European Automotive Company
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Intelligent solution recommendation engine for diagnosing truck fault cases and providing solution recommendations with a probability score to shorten breakdown time for customers. Additionally, designed approach for quick detection and warning of quality patterns.
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Renaissance: Commercial channel and supply partnership between traditional travel tour operator and an online travel operator
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Some articles on the new commercial partnership between Expedia & Thomas Cook:
https://www.ft.com/content/6d8419df-a871-3902-80f9-549373adcb30
http://www.telegraph.co.uk/business/2017/09/14/thomas-cook-plumps-pillows-expedia-hotel-deal/
Role: Chief Architect
Responsibilities: involvement has been across the board in advising on the commercial negotiation process, discovery work with both Expedia and Thomas Cook around business models and channel transformation strategy, working…Some articles on the new commercial partnership between Expedia & Thomas Cook:
https://www.ft.com/content/6d8419df-a871-3902-80f9-549373adcb30
http://www.telegraph.co.uk/business/2017/09/14/thomas-cook-plumps-pillows-expedia-hotel-deal/
Role: Chief Architect
Responsibilities: involvement has been across the board in advising on the commercial negotiation process, discovery work with both Expedia and Thomas Cook around business models and channel transformation strategy, working on shaping and defining the digital, technology and analytics roadmap, as well as designing the change across business, scope, people, process and technology.Other creatorsSee project -
Cloud API: a new centralised microservice integration architecture (in Azure) ~enables multiple digital and traditional channels (mobile, web, Alexa & in-club)
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Conceptulised, designed and defined the strategy for our new cloud API management framework, which uses business related API microservices using Azure iPaaS services (API management, App Suite & Azure Service Bus).
Each service is deployed from code commit via UAT & Staging, into Production in < 5 minutes using an automated test framework, and the latest DevOps technology.
First deploy: June 2016 (with ongoing platform releases weekly)Other creators -
Predictive Churn (PoC): using data science to predict cancellations
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Working with our CIO Andy Caddy and Altius Consulting to define a prototype predictive algorithm and data model to predict the likelihood (2 months before, at 92% accuracy) of a person cancelling their health club membership allowing the business to intervene and win-back earlier. The retention potential this model creates will help the Virgin Active business teams to retain members longer thereby creating more revenue, and ultimately healthier people.
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Cloud Consolidation: Migrating workloads from DC to Cloud
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With the adoption of Azure in late 2015, we undertook an architecture-driven initiative to migrate and transform a large proportion of the workloads in our Data Centre into Azure. This enabled us to rationalise our application portfolio, redefine our data services and rewrite our integration services into microservices (see Cloud API project).
Through the use of resource groups, we aim to optimise our operational expenditure while improving our monitoring and service delivery.Other creators -
Group Cycle ("The Pack") - a new tech-driven and experiential fitness product
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My role was to lead the Group & UK Programme. In addition, I was Technology lead and software solution designer (end-to-end). The programme was a global collaborative effort between Virgin Active territories in the UK, South Africa, Italy, Iberia and APAC.
My CIO, Andy Caddy, was Project Sponsor. I led a cross functional team across UK, EU & SA to navigate and deliver the programme in 9 months.
On 3 May, 2016 we launched 8x clubs in Central London. 10 days later we launched 5…My role was to lead the Group & UK Programme. In addition, I was Technology lead and software solution designer (end-to-end). The programme was a global collaborative effort between Virgin Active territories in the UK, South Africa, Italy, Iberia and APAC.
My CIO, Andy Caddy, was Project Sponsor. I led a cross functional team across UK, EU & SA to navigate and deliver the programme in 9 months.
On 3 May, 2016 we launched 8x clubs in Central London. 10 days later we launched 5 clubs in Italy (3x in Milan, 1 in Florence and 1 in Rome). In July, we added 2 more in London. Group rollout involves: APAC launching 1 club in August, Spain launching 4 clubs in Sept, and South Africa launching 6 in October.
Industry firsts:
1. The Pack works with different bike products (ICG & Technogym)
2. We developed a web platform for instructors to curate their classes (working with Deloitte Digital in South Africa)
3. We included music via an API which works within our web platform and tablet app (Open Ear, MixCloud & Simpfy)
4. We gamified the class using team based challenges (3 teams), clever use of bike metrics averaged across the team while incorporating the class programme and music elements, to drive screen animations, lighting effects and audio cues (and future proofed to include other environmental elements later)
Working with Wolff Olins, we developed a brand (The Pack) and prototyped the studio engine (Experience Manager), which we transitioned to an internal UK development team, and worked with Deloitte and the bike manufacturers to build a smart, complex solution that would scale quickly. We have smart monitoring to check the health of studio elements in real time, so our support teams know about issues before they are known in the clubs, and we can ensure this complex product runs smoothly across multiple clubs several times per day.Other creatorsSee project -
Connected Clubs (Walbrook & Merchant Square): design a tech-savvy customer journey in health clubs.
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Part of 2015 Digtial Transformation Programme.
As Programme & Tech Lead, I worked with my Project Manager, James Tarlton, to design and deliver these beautiful tech-enabled clubs in Central London.
The programme was sponsored by our Group CIO, Andy Caddy.Other creatorsSee project -
Myvirginactive Programme: a Digital Customer journey & engagement platform for our SA members.
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Member Engagement Platform for Virgin Active South Africa. I lead an on-site core team of 25 (growing to 38 at times), to deliver 23 releases in 18 months. These included transformative functional features (booking system for several activities) and an eCommerce module.
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IT Web Review: Myvirginactive
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Review of collabortation between Virgin Active and build partner EOH Microsoft Coastal on the Myvirginactive Programme
Languages
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Afrikaans
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If you are at #QuanCon25 then come say hello at the #KPMG booth to hear about the innovative decision intelligence solutions we’ve been building with…
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