Cora Vacher

Developing a Target Product Profile (TPP) very early on in ATMP development is crucial to ensure that your therapeutic product is designed to meet its intended use and regulatory requirements, increasing the likelihood of producing a safe, effective, and marketable product. Look at your TPP as a strategic document that serves as a common vision across various stakeholders, including regulatory agencies, investors, development and clinical teams, healthcare providers, and so on. It ensures that everyone has a clear understanding of the product’s goals and requirements, allowing for efforts and resources to be focused where needed.

24

Oxford Nanopore announces breakthrough technology performance to deliver complete human genome assemblies and richer multiomic data in London Calling tech update Oxford Nanopore Chief Technology, Innovation and Product Officer Clive G Brown announced breakthrough performance data and new platform updates in his technology update at the company’s annual London Calling conference, held between 21 and 24 May 2024. The talk launched the nanopore-only telomere-to-telomere (T2T) genome assembly product bundle, making this breakthrough method more accessible. In addition, Clive showed a glimpse of what may be possible in the future with the sequencing of a whole T2T yeast chromosome in a single read for the first time. Further improvements in direct RNA sequencing accuracy and yield, and pipelines for ultra-high output sequencing, including a potential route to a 15-minute human genome, were shared. Building on the distinctive advantages of the Oxford Nanopore platform, these advancements deliver highly accurate, information-rich data, faster insights, at any scale for both DNA and RNA sequencing applications. Oxford Nanopore’s technology continues to evolve to meet the growing demand for accessible, real-time analysis and open new possibilities in research, clinical and industrial settings. https://lnkd.in/gt5uifM5

10

Exploring RAS and RAF Target Engagement: Live-Cell Insights into Molecular Specificity 🔎 Check out a new #PromegaNotes article to discover advanced assay technologies, such as live-cell #NanoBRET® TE Intracellular Assays, reshaping the landscape of drug discovery methods and offering biologically relevant models for enhanced research. https://bit.ly/3zEFa3O #CancerResearch #oncology #lifescience

3

Delighted to announce that MRC PPU Reagents and Services are now offering NGS amplicon sequencing on our Illumina MiSeq platform. Designed for precision and efficiency, our service provides detailed insights into targeted genomic regions for applications across research, clinical, and industrial fields. We accept bead-purified PCR-products for library preparation in our dedicated sequencing laboratory. Find out how we can help your research by visiting https://dnaseq.co.uk/

31

Want to catch bacterial contamination early in your CHO cell cultures? Aber Instruments Ltd's webinar (link below!) explores how conductivity & dielectric spectroscopy can help with real-time monitoring & process automation. https://lnkd.in/eQPxdiGj #WebinarAlert #bioprocess #biotechnology #ProcessAutomation #CellCulture #ContaminationDetection #learning

4

Looking forward to discussing strategies to build the UK as a scientific powerhouse! Excited for the focus on an industrial strategy driven by government officials, academic leaders, and the private sector. #UK #science #industrialstrategy

34

BI and Ciulli's lab have developed ACBI3 (PROTAC) that has shown to be able to eliminate 13 out of the 17 most common KRAS mutants with high potency and selectivity. "KRAS degradation by ACBI3 was also more efficacious than using KRAS small molecule inhibition, and induced effective tumour regression in mouse models, validating KRAS degradation as a novel therapeutic concept" just published in Science https://buff.ly/3Xzmriu

5

This time next week (Thursday 26th), join me and Alysha Bray to learn how you can use CN Bio PhysioMimix liver MPS to translate between in vitro, in vivo and the clinic for safety assessments. Register for the webinar here: https://lnkd.in/emR3X7u9 Be there or be square (not a circle like me and Alysha in this image...) #CNBioat #webinar #OrganonaChip #MPS #liver #DILI #toxicity #toxicology

60

Copy number + SNV ! Combining these two data sources from embryo biopsies to get the most accurate PGT-A. This was definitely the main theme of this year's #PGDIS2024 presentations. Lots of groups are looking to do this with SNP array based PGTA (some great presentations), low pass NGS sequencing (tough to get good SNP data), amplicon based NGS (tough to get good CNV data). So it was great to see the #PTA PGTA data presented by Chris Weier The PTA based CNV+SNP (SNV) data just keeps on blowing us away with the ultra low noise CNV and the super high fidelity SNP data. MAPD <0.03 is normal and 150K SNP on a standard PGTA. It really is the best of both worlds for CNV and SNP reporting. Chris presented the example below from a PTA amped sample showing two 40% mosaic aneuploidies and - really for the first time - demonstrating PGT-A SNP based mosaic calling beautifully correlating with CNV mosaic calling. It's easy to spot by eye in the B-allele plot for chr7 and chr13, then to see it in the CNV plot. Although of course we do this calling automatically with #PGTai. Independently CNV and SNP calling mosaics and aneuploidies. It's the future of PGT-A. There is plenty more to come and the inventor of #PTA Charles Gawad #bioskryb hinted about the PTA future in a tour de force #PGDIS2024 presentation. Exciting times! #coopersurgical

112

3 Comments

Come and catch Brittany Wingham🌱, Kiran Sharma and myself at the Single Cell Biology conference at the Wellcome Sanger Institute today to discuss scaling your single cell research with the power of benchtop automation! #singlecell

35

Deep insights can be gained for immunologists with nanopore sequencing!!!

6

I'm catching up on the exciting talks from ASMS2024 on the Xevo MRT! Click below to see how it's been applied to important questions such as Parkinson's Disease, traumatic brain injury, natural products, and more!

7

Benchmarking metabolomics software just got more precise: this novel simulated and experimental LC-MS data sets reveal that MVAPACK outperforms existing tools, offering unparalleled clarity in both NMR and MS data analysis. #Metabolomics #DataScience #HealthcareInnovation https://lnkd.in/ggBb-XEe

4

I am incredibly proud to announce that we have been awarded a £1.6M project from Innovate UK’s Biomedical Catalyst 2023 Round 2: Industry-led R&D 🙌 This application took a tremendous amount of effort, including working well into the early hours of many mornings to perfect the initial submission and cancelling leave over Christmas to prepare for the interview stage. Innovate UK grants (rightly!) require significant work; the application is scrutinised by five experienced assessors from various areas across Life Sciences. The next-stage interview is then attended by up to ten other people, with our panel including professionals from the NHS, academia, and CDMOs, among others. With a pot of £17.8M, and average project cost at £415,191, only 30 of the 358 applications could be funded 💰 . It is therefore truly gratifying to have so many experts agree that the cause we are developing solutions for is important and worthy of this substantial investment ✊ We do not take this funding lightly and will work tirelessly to ensure the success of our exciting project. Time to get cracking! https://lnkd.in/ev58aTt8 #biomedicalcatalyst #healthcare #infantmicrobiome #microbiome #grantfunding #grants #investment #innovateuk #biotech

464

54 Comments

Discover cfDNA insights. Uncover a comprehensive cell-free DNA (cfDNA) isolation workflow addressing analyte fragmentation and yield issues. Read the app notes: https://lnkd.in/eT5ebh4P ​

1

You can still register for this webinar, demonstrating the Quantum-Aided Drug Design (#QuADD) platform.

10

Library preparation automation Automated preparation for streamlined answers The range of devices available from Oxford Nanopore enables sequencing at every scale — from the single-use Flongle Flow Cell generating 1-2 Gbases of data, right through to the PromethION 48 with terabase-scale outputs. Automation of library preparation can help throughout this range. It improves the overall consistency of results, supporting robust and standardised workflows, which enables increased sample throughput for medium- and large-scale projects, such as large cohort studies. Our streamlined library preparation kits are easy to automate, and protocols are available for a range of liquid handlers. https://lnkd.in/gDUjbd67

1

⚡ Make Transformation easy ⚡ #Microbiology #Labs in the UK and Ireland today are transforming their models of delivery enabling responsive, better-quality services. This aids earlier #diagnosis, improving patient outcomes. However, recruitment and retention of staff remains a significant challenge for #Pathology services. In the #UK and #Ireland, bioMérieux have a local, dedicated team of Laboratory Consultants who are Specialists in Microbiology. We take the time to understand you. 💡 Our Lab Consultants bring bioMérieux’s 60 years of Microbiology expertise and #innovation to adapt and design your solution around your precise needs, set up and workflow. Not only that, but we empower and support your staff to ease them into their new ways of working through our fun and engaging change management workshops. We understand your services never stand still and foster continued innovation within our #partnerships. We will empower your staff throughout our partnership by offering access to our #ChangeManagement and #ConsultancyServices, career development opportunities and learning and development support tools to help your services attract and retain the best talent.  #beagamechanger bioMérieux Clinical Diagnostics (IVD) Chantal Cyman

4

🌟 NEW CASE STUDY 🌟 👩‍🔬 Forensic researchers at King's College London are harnessing cutting-edge equipment from Thermo Fisher Scientific to delve into critical #research concerning the detection of #drugs in human samples with suspected acute drug #toxicity. 💡 This partnership, involving the university, Guy's and St Thomas'​ NHS Foundation Trust, and Thermo Fisher Scientific, aims to revolutionize the analysis of #blood samples from patients presenting with acute drug toxicity in the #emergency department (#ED). 🏥 The potential impact? Faster, more precise #detection and #quantification methods for acute drug toxicity that could become routine in hospitals, ultimately improving health outcomes for individuals in the emergency department. https://lnkd.in/enM4VPDb Edward Goucher | Alexandra Graham | Vincenzo Abbate | Paul Dargan

62

1 Comment