Adrian Alexa

Adrian Alexa

Cambridge, England, United Kingdom
2K followers 500+ connections

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About

Tech leader with tried and tested leadership skills and wide-ranging experience across…

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Activity

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Experience

  • Daset Labs Graphic

    Daset Labs

    Cambridge, England, United Kingdom

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    Cambridge, United Kingdom

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    England, United Kingdom

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    London, England, United Kingdom

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    Cambridge

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    London, United Kingdom

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    Cambridge, England, United Kingdom

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    Toronto, Canada Area

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    Toronto, Canada Area

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    Cambridge, United Kingdom

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    Cambridge, United Kingdom

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    Cambridge, United Kingdom

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    Cambridge, United Kingdom

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    Saarbrücken, Germany

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Education

  • Universität des Saarlandes Graphic

    Universität des Saarlandes

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    Master of Science

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    A programme for accelerated leadership growth in Cambridge businesses. As a company grows from start-up to scale-up it needs to develop leadership and succession at many levels. Leaders and managers need a complex set of skills to deal with the challenges they face including forming and getting the best out of a team. CEOs deal with team and people issues, usually while delivering the day job. Inspiring, well-informed leaders throughout the business make a huge difference to the level of…

    A programme for accelerated leadership growth in Cambridge businesses. As a company grows from start-up to scale-up it needs to develop leadership and succession at many levels. Leaders and managers need a complex set of skills to deal with the challenges they face including forming and getting the best out of a team. CEOs deal with team and people issues, usually while delivering the day job. Inspiring, well-informed leaders throughout the business make a huge difference to the level of success a business can achieve.

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    Activities and Societies: Students’ representative member in the University Board at Bucharest University

    Bachelor of Science (BSc)

Volunteer Experience

  • DNA Digest Graphic

    Data Scientist

    DNA Digest

    - 4 years

    Science and Technology

Publications

  • The Open Science Peer Review Oath

    F1000Research

    One of the foundations of the scientific method is to be able to reproduce experiments and corroborate the results of research that has been done before. However, with the increasing complexities of new technologies and techniques, coupled with the specialisation of experiments, reproducing research findings has become a growing challenge. Clearly, scientific methods must be conveyed succinctly, and with clarity and rigour, in order for research to be reproducible. Here, we propose steps to…

    One of the foundations of the scientific method is to be able to reproduce experiments and corroborate the results of research that has been done before. However, with the increasing complexities of new technologies and techniques, coupled with the specialisation of experiments, reproducing research findings has become a growing challenge. Clearly, scientific methods must be conveyed succinctly, and with clarity and rigour, in order for research to be reproducible. Here, we propose steps to help increase the transparency of the scientific method and the reproducibility of research results: specifically, we introduce a peer-review oath and accompanying manifesto. These have been designed to offer guidelines to enable reviewers (with the minimum friction or bias) to follow and apply open science principles, and support the ideas of transparency, reproducibility and ultimately greater societal impact. Introducing the oath and manifesto at the stage of peer review will help to check that the research being published includes everything that other researchers would need to successfully repeat the work. Peer review is the lynchpin of the publishing system: encouraging the community to consciously (and conscientiously) uphold these principles should help to improve published papers, increase confidence in the reproducibility of the work and, ultimately, provide strategic benefits to authors and their institutions. Future incarnations of the various national Research Excellence Frameworks (REFs) will evolve away from simple citations towards measurable societal value and impact. The proposed manifesto aspires to facilitate this goal by making transparency, reproducibility and citizen-scientist engagement (with the knowledge-creation and dissemination processes) the default parameters for performing sound research.

    Other authors
    See publication

  • Improved scoring of functional groups from gene expression data by decorrelating GO graph structure

    Bioinformatics

    Motivation: The result of a typical microarray experiment is a long list of genes with corresponding expression measurements. This list is only the starting point for a meaningful biological interpretation. Modern methods identify relevant biological processes or functions from gene expression data by scoring the statistical significance of predefined functional gene groups, e.g. based on Gene Ontology (GO). We develop methods that increase the explanatory power of this approach by integrating…

    Motivation: The result of a typical microarray experiment is a long list of genes with corresponding expression measurements. This list is only the starting point for a meaningful biological interpretation. Modern methods identify relevant biological processes or functions from gene expression data by scoring the statistical significance of predefined functional gene groups, e.g. based on Gene Ontology (GO). We develop methods that increase the explanatory power of this approach by integrating knowledge about relationships between the GO terms into the calculation of the statistical significance.

    Results: We present two novel algorithms that improve GO group scoring using the underlying GO graph topology. The algorithms are evaluated on real and simulated gene expression data. We show that both methods eliminate local dependencies between GO terms and point to relevant areas in the GO graph that remain undetected with state-of-the-art algorithms for scoring functional terms. A simulation study demonstrates that the new methods exhibit a higher level of detecting relevant biological terms than competing methods.

    Other authors
    • Jörg Rahnenführer
    • Thomas Lengauer
    See publication

Courses

  • Scaling Up Business Growth Workshop - Gazelles International

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Languages

  • Romanian

    Native or bilingual proficiency

  • English

    Native or bilingual proficiency

  • Italian

    Limited working proficiency

  • German

    Limited working proficiency

  • Spanish

    Limited working proficiency

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