Ro04-6790
Ro04-6790 je lek koji se koristi u naučnim istraživanjima. On deluje kao potentan i selektivan receptorski antagonist za 5-HT6 serotoninski receptor, sa malim ili odsustvom afiniteta za druge receptore. Poput drugih lekova ove klase,[1] Ro04-6790 ima nootropne efekte na životinjama,[2] i redukuje amneziju proizvedenu lekovima koji ugrožavaju memoriju, kao što je dizocilpin[3] i skopolamin.[4]
 | |
| IUPAC ime | |
|---|---|
4-amino-N-[2,6-bis(metilamino)-4-pirimidinil]-benzensulfonamid | |
| Identifikatori | |
| CAS broj | 202466-68-0  |
| ATC kod | none |
| PubChem | CID 5312145 |
| IUPHAR/BPS | 274 |
| Hemijski podaci | |
| Formula | C12H16N6O2S |
| Molarna masa | 308,359 g/mol |
| |
Reference
уреди- ^ Fone, Kevin C.F. (2008). „An update on the role of the 5-hydroxytryptamine6 receptor in cognitive function”. Neuropharmacology. 55 (6): 1015—1022. PMID 18655798. S2CID 35522597. doi:10.1016/j.neuropharm.2008.06.061.
- ^ King, M. V.; Spicer, C. H.; Sleight, A. J.; Marsden, C. A.; Fone, K. C. (2009). „Impact of regional 5-HT depletion on the cognitive enhancing effects of a typical 5-ht(6) receptor antagonist, Ro 04-6790, in the Novel Object Discrimination task”. Psychopharmacology. 202 (1–3): 111—123. PMID 18839151. S2CID 10826081. doi:10.1007/s00213-008-1334-1.
- ^ Pitsikas, N.; Zisopoulou, S.; Pappas, I.; Sakellaridis, N. (2008). „The selective 5-HT(6) receptor antagonist Ro 04-6790 attenuates psychotomimetic effects of the NMDA receptor antagonist MK-801”. Behavioural Brain Research. 188 (2): 304—309. PMID 18164078. S2CID 40183481. doi:10.1016/j.bbr.2007.11.010.
- ^ Woolley, M. L.; Marsden, C. A.; Sleight, A. J.; Fone, K. C. (2003). „Reversal of a cholinergic-induced deficit in a rodent model of recognition memory by the selective 5-HT6 receptor antagonist, Ro 04-6790” (PDF). Psychopharmacology. 170 (4): 358—367. PMID 13680084. S2CID 25193679. doi:10.1007/s00213-003-1552-5.
