Ro04-6790 je lek koji se koristi u naučnim istraživanjima. On deluje kao potentan i selektivan receptorski antagonist za 5-HT6 serotoninski receptor, sa malim ili odsustvom afiniteta za druge receptore. Poput drugih lekova ove klase,[3] Ro04-6790 ima nootropne efekte na životinjama,[4] i redukuje amneziju proizvedenu lekovima koji ugrožavaju memoriju, kao što je dizocilpin[5] i skopolamin.[6]
Ro04-6790
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| (IUPAC) ime
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| 4-amino-N-[2,6-bis(metilamino)-4-pirimidinil]-benzensulfonamid
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| Klinički podaci
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| Identifikatori
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| CAS broj
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202466-68-0
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| ATC kod
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nije dodeljen
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| PubChem[1][2]
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5312145
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| Hemijski podaci
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| Formula
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C12H16N6O2S
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| Mol. masa
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308,359 g/mol
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| SMILES
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eMolekuli & PubHem
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| InChI |
|---|
InChI=1S/C12H16N6O2S/c1-14-10-7-11(17-12(15-2)16-10)18-21(19,20)9-5-3-8(13)4-6-9/h3-7H,13H2,1-2H3,(H3,14,15,16,17,18)  Y
Key: JELFWSXQTXRMAJ-UHFFFAOYSA-N Y |
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| Farmakoinformacioni podaci
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| Trudnoća
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?
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| Pravni status
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- ↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
- ↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
- ↑ Fone KC. An update on the role of the 5-hydroxytryptamine6 receptor in cognitive function. Neuropharmacology. 2008 Nov;55(6):1015-22. DOI:10.1016/j.neuropharm.2008.06.061 PMID 18655798
- ↑ King MV, Spicer CH, Sleight AJ, Marsden CA, Fone KC. Impact of regional 5-HT depletion on the cognitive enhancing effects of a typical 5-ht(6) receptor antagonist, Ro 04-6790, in the Novel Object Discrimination task. Psychopharmacology (Berlin). 2008 Oct 7. PMID 18839151
- ↑ Pitsikas N, Zisopoulou S, Pappas I, Sakellaridis N. The selective 5-HT(6) receptor antagonist Ro 04-6790 attenuates psychotomimetic effects of the NMDA receptor antagonist MK-801. Behavioural Brain Research. 2008 Apr 9;188(2):304-9. PMID 18164078
- ↑ Woolley ML, Marsden CA, Sleight AJ, Fone KC. Reversal of a cholinergic-induced deficit in a rodent model of recognition memory by the selective 5-HT6 receptor antagonist, Ro 04-6790. Psychopharmacology (Berlin). 2003 Dec;170(4):358-67. PMID 13680084
