Alprenolol (alfeprol, alprenololum, gubernal, regletin, yobir, aplobal, aptine, aptol duriles), je neselektivni beta blokator kao i antagonist 5-HT1A receptor, koji se koristi u lečenju angine pektoris.[6] Njega više ne prodaje AstraZeneca, ali je dostupan od drugih farmaceutskih kompanija kao generički lek.

Alprenolol
(IUPAC) ime
(RS)-1-(2-allylphenoxy)-3-(isopropylamino)propan-2-ol
Klinički podaci
Identifikatori
CAS broj 13655-52-2
ATC kod C07AA01
PubChem[1][2] 2119
ChemSpider[3] 2035
UNII 877K5MQ27W DaY
KEGG[4] D07156
ChEMBL[5] CHEMBL266195 DaY
Hemijski podaci
Formula C15H23NO2 
Mol. masa 249.34 g/mol
SMILES eMolekuli & PubHem
Farmakokinetički podaci
Vezivanje za proteine plazme 80% - 90%
Poluvreme eliminacije 2-3 časa → 4-OH-alprenolol
Farmakoinformacioni podaci
Trudnoća ?
Pravni status
Način primene Oralno

Literatura

uredi
  1. Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519.  edit
  2. Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1. 
  3. Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846.  edit
  4. Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H. 
  5. Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594.  edit
  6. Hickie JB (August 1970). „Alprenolol ("aptin") in angina pectoris. A double-blind multicentre trial”. Med. J. Aust. 2 (6): 268–72. PMID 4393977.