Post-translational modification (PTM) of proteins allows cells to regulate protein functions,
transduce signals and respond to perturbations. PTMs expand protein functionality and …

Protein phosphorylation is a complex network of signaling and regulatory events that affects
virtually every cellular process. Our understanding of the nature of this network as a whole …

Determining the site of a regulatory phosphorylation event is often essential for elucidating
specific kinase–substrate relationships, providing a handle for understanding essential …

Although most tissues in an organism are genetically identical, the biochemistry of each is
optimized to fulfill its unique physiological roles, with important consequences for human …

Cross-talk between different types of post-translational modifications on the same protein
molecule adds specificity and combinatorial logic to signal processing, but it has not been …

The eukaryotic cell division cycle is characterized by a sequence of orderly and highly
regulated events resulting in the duplication and separation of all cellular material into two …

MicroRNAs are endogenous∼ 23-nucleotide RNAs that can pair to sites in the messenger
RNAs of protein-coding genes to downregulate the expression from these messages …

Data analysis and interpretation remain major logistical challenges when attempting to
identify large numbers of protein phosphorylation sites by nanoscale reverse-phase liquid …

To explore the mechanisms and evolution of cell-cycle control, we analyzed the position and
conservation of large numbers of phosphorylation sites for the cyclin-dependent kinase …

The evolutionarily conserved serine-threonine kinase mammalian target of rapamycin
(mTOR) plays a critical role in regulating many pathophysiological processes. Functional …