Background Unresectable locally advanced or metastatic triple-negative (hormone-receptor–
negative and human epidermal growth factor receptor 2 [HER2]–negative) breast cancer is …

T cell receptors (TCRs) enable T cells to specifically recognize mutations in cancer cells,–.
Here we developed a clinical-grade approach based on CRISPR–Cas9 non-viral precision …

Anti-tumour immune activation by checkpoint inhibitors leads to durable responses in a
variety of cancers, but combination approaches are required to extend this benefit beyond a …

Animals have different muscle fibre types: slow fibres with a low maximum velocity of
shortening (V max) and fast fibres with a high V max. An advantage conferred by the use of …

Importance The humanized monoclonal antibody atezolizumab targets programmed death-
ligand 1 and has demonstrated durable single-agent activity in a subset of metastatic triple …

Programmed death-ligand 1 (PD-L1) expression on tumor cells (TCs) by
immunohistochemistry is rapidly gaining importance as a diagnostic for the selection or …

Objectives Activated Wnt signalling with decreased expression of endogenous inhibitors has
recently been characterised as a central pathomechanism in systemic sclerosis (SSc) …

Abstract Introduction The FIR phase II study (NCT01846416) evaluated the efficacy and
safety of anti–programmed death-ligand 1 (PD-L1) atezolizumab in advanced NSCLC …

1009 Background: Atezolizumab (atezo; MPDL3280A) is a humanized MAb that inhibits
binding of PD-L1 to PD-1 and B7. 1, thus restoring tumor-specific T-cell immunity. Atezo has …

Background Laparoscopic sleeve gastrectomy (LSG) is an emerging surgical technique with
encouraging results. The objective of this study is to report surgical results after 1,000 …