Extracellular Vesicles in Clinical Applications - EVCA

I’m happy to share that my first review has just been published! 📢 In this work, co-authored with Ana Talamillo and Juan Manuel Falcón from the Exosomes Lab at CIC bioGUNE, we explore the broad landscape of inhibitors of extracellular vesicle biogenesis and secretion. This review provides a comprehensive overview of the most widely studied EV inhibitors, highlighting their mechanisms of action, experimental applications, and therapeutic potential. We place particular emphasis on their advantages and limitations as modulators of EV biogenesis, with the goal of helping guide future research toward more effective and selective strategies. Special thanks to Extracellular Vesicles in Clinical Applications - EVCA and HaltRONIN Horizon for their support. https://lnkd.in/eRGfbg9X

Some weeks ago, I had the opportunity to attend Extracellular Vesicles in Clinical Applications - EVCA’s final meeting. Sort of a bittersweet moment. A bit of context: I attended EVCA’s kick-off meeting just two weeks after starting my PhD. Back then, I didn’t know much about extracellular vesicles (EVs), but I was excited to begin my journey in this cool field. It’s incredible to see how much has changed since then and how much I have grown both as a scientist and as a person. EVCA has been like the godmother of my PhD journey. It gave me the space to present project ideas and engage in fruitful discussions with EVs experts. It was during an EVCA meeting that I first shared the idea for our bioinformatics tool, EV-Net, even before we secured funding to develop it in collaboration with Anaïs Baudot. Now, in my (hopefully) final year of my PhD, I had the chance to present this journey during the EVCA meeting. My talk focused less on the technical details of the tool and more on the roadmap, from the initial project idea to execution and dissemination, highlighting EVCA’s support along the way. It was well received, and we are currently discussing the possibility of giving an EV-Net workshop for potential users at a partner lab. EVCA also supported my attendance at international conferences that had a significant impact on my career. Thanks to EVCA, I attended RECOMB 2024 in Cambridge and ISEV2025 in Vienna. At ISEV2025, I presented a preliminary version of EV-Net and connected with potential users. Also, I had the chance to meet my ISEV mentor, Roosmarijn Vandenbroucke, in person. During the final EVCA meeting I had many enriching discussions about EV research and life as scientists. I will miss EVCA, but I’m sure that its impact on me as a person and the connections I’ve made will last a lifetime. Thank you Rune Matthiesen, Ana Maria Aransay, Felix Elortza, Juan Manuel Falcon Perez, Marca Wauben and Graça Raposo for the discussions and I hope to see you again in future EV initiatives! P.S. I realized I took a little break from LinkedIn since last year without really noticing, but I’m back :D I’ll try to post more regularly because I genuinely enjoy sharing and connecting here.

Recap of the amazing seminar today at NOVA Medical School - Faculdade de Ciências Médicas! Today, February 27th, NMS hosted an inspiring seminar on “Communicating Science in the Age of AI”, organised by iNOVA4Health and the EVCA Twinning Project. The session, led by SILVIA FERNANDEZ, science communication specialist and founder of DE ROTOS Y DESCOSIDOS, explored how AI is transforming the production, dissemination, and perception of scientific knowledge. After the seminar, attendees enjoyed a lively networking session with drinks and snacks, exchanging ideas and experiences in an informal setting. A big thank you to Sílvia for her engaging talk and to everyone who joined us — it was a fantastic afternoon of learning, discussion, and connection! #EVCATwinning #iNOVA4Health #ScienceCommunication #ArtificialIntelligence #NMS #ResearchCommunication #AIinScience #Networking Everest consortium Extracellular Vesicles in Clinical Applications - EVCA

📢 Seminar at NOVA Medical School - Faculdade de Ciências Médicas: Communicating Science in the Age of AI Tomorrow, February 27th at 4pm, NOVA Medical School will host the seminar “Communicating Science in the Age of AI”, organised by iNOVA4Health and Extracellular Vesicles in Clinical Applications - EVCA. The session will take place at the MMM Auditorium and will be delivered by SILVIA FERNANDEZ, science communication specialist and founder of DE ROTOS Y DESCOSIDOS, currently at NMS through an exchange within the European project EVEREST (Everest consortium). In a context where Artificial Intelligence is already influencing the production, dissemination, and perception of scientific knowledge, this seminar will provide a valuable opportunity to reflect on the challenges, risks, and new possibilities shaping science communication today. 📍 MMM Auditorium 🗓 February 27 🕓 16:00 🥂 Networking session after the seminar We look forward to seeing you there! #EVCATwinning #iNOVA4Health #ScienceCommunication #ArtificialIntelligence #NMS

Another EVCA Club session took place on December 15th at NOVA Medical School - Faculdade de Ciências Médicas School! This EVCA Club brought together two compelling presentations: Rune Matthiesen (Principal Investigator) shared insights into systemic immune suppression in diffuse large B-cell lymphoma (DLBCL), showing how tumor-derived extracellular vesicles can induce polyubiquitination and compromise the viability of peripheral blood mononuclear cells. Duarte Barral (Principal Investigator) presented a 3D cutaneous melanoma in vitro model as an innovative platform to study melanoma-derived extracellular vesicles and their impact on tumor biology. We thank both speakers for their excellent contributions and all participants for the engaging discussion. EVCA Club continues to foster scientific exchange and collaboration within our extracellular vesicles research community. Stay tuned for upcoming EVCA Club sessions! #EVCATwinning #EVCAClub #ExtracellularVesicles #HorizonEU

EVCA at DrosTuga 2025 We are happy to share that EVCA participated and co-organized an amazing keynote session in DrosTuga 2025! The event brought together researchers from across Portugal to discuss innovative work using Drosophila melanogasteras a model to explore biological mechanisms with relevance to human health. EVCA was featured throughout the event, highlighting our support for strengthening collaborative research communities in Portugal. We were also delighted to welcome Sofia J. A., who delivered an amazing talk on "Centrosomes, cytoskeletal organization, and vesicular dynamics in branching cells". A big thank-you to the organizers, speakers, and all attendees for contributing to such a dynamic and engaging scientific exchange. We look forward to future opportunities to keep supporting and connecting the community! #EVCATwinning #DrosTuga2025 #Drosophila #Collaboration #EVResearch #ScientificCommunity