Laverne Cox Shakes Things Up as She Returns to Small-Town Living in Late Norman Lear's New Comedy Clean Slate (Exclusive)

Laverne Cox is making her mark in Prime Video's new comedy, Clean Slate.

In PEOPLE's first look at the heartfelt series, Cox, 52, takes on the role of Desiree, a proud trans woman who returns to her small town in Alabama when her New York City art gallery goes under.

"The show follows Harry Slate (George Wallace), an old-school and outspoken Alabama car wash owner, who has a lot of soul searching to do when the estranged child he thought was a son returns home to Mobile as a proud, trans woman, Desiree," the synopsis reads. "Desiree works to repair the fraught relationship with her father, navigating their relationship while contending with vastly different points of view as roommates. They find themselves facing all of the hilarious coming-of-age milestones they missed out on the first time around."

Alongside Cox and Wallace, the series — which comes from late producer and television icon, Norman Lear, who died at age 101 in December 2023 — also stars D.K. Uzoukwu as Louis, Telma Hopkins as Ella, Jay Wilkison as Mack and Norah Murphy as Opal.

In the trailer, it's clear from the start that Harry and Desiree have a lot of work to do.

"Hi, Miss Fancy Lady!" Harry says as he answers the door. "This really isn't a good time right now. My son's coming any minute."

"Dad, I'm your daughter, Desiree. I've always been Desiree," she replies as her father looks on with a bewildered look on his face.

Though it's been "23 years" since they've seen each other, the two attempt to rekindle their bond as Harry shows her around her childhood home where everything looks "exactly the same."

As Desiree settles back into her hometown in Alabama, she catches up with old friends. When her closeted best friend and choir director, Louis (D.K. Uzoukwu), asks why she's returned, she sighs, "I arranged for a gallery space and then my funding fell through."

"You're bus broke," he then quips, to which Desiree claps back with a laugh: "And you live with your mama, broke!"

Though Harry and Desiree's long-awaited reunion isn't without its kinks, no one can deny that her return and her choice to open up is a "major step" in their relationship. When she spends her first night back in her childhood bedroom, she admits, "I'm totally gonna have to redecorate."

Eventually, they butt heads over generational differences. As Desiree tries to relax with a face mask, she states, "Don't gaslight me, dad," to which Harry replies, "I wouldn't do that because I don't know what that is."

Elsewhere in the trailer, Desiree declares it's time to "declutter" their home. When she suggests an "eye sore" painting of the Last Supper be removed, Harry yells, "This is my prized possession, and it ain't going nowhere, son! Daughter, damn it!"

Desiree also works to hold her father accountable, presenting him with a "pronoun jar" after he misgenders her. "Jar," Desiree nonchalantly says before Harry reluctantly adds a dollar to it.

"I'm going to retire off this," she quips in a final moment of the trailer.

In the end, "Desiree thought her homecoming would be temporary, but her return results in her planting fresh roots, and realizing that there may be space for her in Mobile after all," according to a synopsis.

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Clean Slate premieres Feb. 6 on Prime Video.