Juliette van den Dolder

𝗡𝗮𝘃𝗶𝗴𝗮𝘁𝗶𝗻𝗴 𝘁𝗵𝗲 𝗖𝗼𝗺𝗽𝗹𝗲𝘅𝗶𝘁𝗶𝗲𝘀 𝗼𝗳 𝗢𝗿𝗴𝗮𝗻𝗼𝗶𝗱 𝗖𝘂𝗹𝘁𝘂𝗿𝗲 Organoids, miniature 3D structures grown from stem or differentiated cells, mimic organ architecture and function, advancing beyond traditional cell culture methods. The SCINUS bioreactor NG, with precise control over oxygen levels, nutrient supply, and mechanical stimulation, enhances organoid growth and maturation. Want to know more about the ins and outs of organoids? Read our newest blog post! https://lnkd.in/eEGxJ-PM #Organoids #CellCulture #DiseaseModeling #SCINUSbioreactorNG

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Synaffix BV today announces it has entered into a licensing agreement with Illumina, a global leader in DNA sequencing and array-based technologies.   The agreement grants #Illumina access to Synaffix's patented metal-free click chemistry, for next-generation DNA sequencing applications.   For more information, please see the full press release linked in the comments below.   #drugdevelopment #NGS #metalfreeclickchemistry #DNA

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👋 𝗘𝗥𝗕𝗖 𝗶𝘀 𝗮𝘁𝘁𝗲𝗻𝗱𝗶𝗻𝗴 𝘁𝗵𝗲 𝗔𝗖𝗧 𝟰𝟱𝘁𝗵 𝗮𝗻𝗻𝘂𝗮𝗹 𝗠𝗲𝗲𝘁𝗶𝗻𝗴, 𝗡𝗼𝘃𝗲𝗺𝗯𝗲𝗿 𝟭𝟳-𝟮𝟬, 𝗼𝗿𝗴𝗮𝗻𝗶𝘀𝗲𝗱 𝗯𝘆 𝘁𝗵𝗲 American College of Toxicology (ACT). We invite you to meet with Frank Visser, and Raafat Fares on November 17-20. We're looking forward to connecting and exploring new opportunities for collaboration. #lifescience #biotechevent #nonclinical #CRO #partnering #drugdevelopment #3Rs #toxicology

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𝗧𝗵𝗲 𝗽𝗼𝘁𝗲𝗻𝘁𝗶𝗮𝗹 𝗼𝗳 𝗶𝗣𝗦𝗖𝘀: 𝗢𝘃𝗲𝗿𝗰𝗼𝗺𝗶𝗻𝗴 𝗖𝗵𝗮𝗹𝗹𝗲𝗻𝗴𝗲𝘀 𝗳𝗼𝗿 𝗖𝗹𝗶𝗻𝗶𝗰𝗮𝗹 𝗔𝗽𝗽𝗹𝗶𝗰𝗮𝘁𝗶𝗼𝗻𝘀 The unique nature of induced pluripotent stem cells (iPSCs) lies in their capability for unlimited self–renewal and programmed differentiation into virtually any adult cell type. SCINUS is actively focusing on solving the technical challenges in generating high-quality reliable iPSCs for various clinical applications, drug screening and disease modelling. Read more on this fascinating cell type and the challenges that still remain in our latest blogpost: https://lnkd.in/en-mzGZy

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In the month of December we all tend to reflect on the past 11 months of the year. At JJP Biologics in the month of December we will reflect on our valued academic collaborations by highlighting their publications of 2024 in which we have contributed. The publication from Diede Houbaert from the group of Prof. Patrizia Agostinis at the KU Leuven in Leuven, Belgium shows that loss of Lymphatic endothelial cells (LEC) autophagy prevents recruitment of tumor-infiltrating T and natural killer cells and abrogates response to immunotherapy. https://lnkd.in/d2M-vKeF We are very grateful as JJP Biologics to be able to contribute to these important academic studies. Because "For patients we need to do better" https://lnkd.in/dyJb3j3C Stay tuned with JJP Biologics and follow us here on LinkedIn. Be a smart goose 🎆🎆 https://lnkd.in/eZV3ZbS9 #ABM, #biotechnology, #JJP1212, #JJP1008, #SMARTGOOSE

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𝗬𝗼𝘂 𝗵𝗮𝘃𝗲 𝗱𝗲𝗰𝗶𝗱𝗲𝗱! 𝗧𝗵𝗶𝘀 𝗶𝘀 𝘁𝗵𝗲 𝗺𝗼𝘀𝘁 𝗿𝗲𝗮𝗱 𝗬𝗠𝗖 𝗻𝗲𝘄𝘀𝗹𝗲𝘁𝘁𝗲𝗿 𝗮𝗿𝘁𝗶𝗰𝗹𝗲 𝟮𝟬𝟮𝟰👇🏼 𝗜𝗺𝗽𝗿𝗼𝘃𝗲 𝘆𝗼𝘂𝗿 𝘂𝗻𝘁𝗮𝗿𝗴𝗲𝘁𝗲𝗱 𝗽𝗼𝗹𝗮𝗿 𝗺𝗲𝘁𝗮𝗯𝗼𝗹𝗶𝘁𝗲 𝗽𝗿𝗼𝗳𝗶𝗹𝗶𝗻𝗴 In this application note you will learn how to make your analysis 𝗲𝘃𝗲𝗻 𝗺𝗼𝗿𝗲 𝘀𝗲𝗻𝘀𝗶𝘁𝗶𝘃𝗲. The sample in this example is polar metabolites in human plasma using the advanced YMC Accura Triart Diol-HILIC column. This method ensures the highest sensitivity and resolution of endogenous isomers. By using the bioinert-coated YMC Accura Triart Diol-HILIC column, conditioning is achieved quickly after just four injections. This guarantees 𝗰𝗼𝗻𝘀𝗶𝘀𝘁𝗲𝗻𝘁 and 𝗿𝗲𝗽𝗿𝗼𝗱𝘂𝗰𝗶𝗯𝗹𝗲 𝗿𝗲𝘀𝘂𝗹𝘁𝘀. To access full details and gain a competitive edge in your field download the application note 👉🏼 https://ymc.eu/d/brDpU You haven’t signed up for the YMC newsletter yet? Sign up and stay up to date on current HPLC topics, upcoming events and receive valuable expert tips: https://lnkd.in/ePphQG2T   #newsletter #mostread #article #TheSelectivityCompany

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Congratulations to Bavo Vandekerckhove, Bart Ruttens,Bert Metten, and their team for their published paper about inline crystallization and pulsed flow operation to enable enantiospecific solid state photodecarbonylation (the link to the paper is in the comments)! 🎉 The integration of inline crystallization with pulsed flow operation represents a significant advancement in enabling enantiospecific solid-state photodecarbonylation. This innovative approach leverages precise control over crystallization and flow dynamics, facilitating the selective formation of desired enantiomers. The process enhances the efficiency and specificity of photodecarbonylation reactions, crucial in the synthesis of chiral compounds. By merging these techniques, researchers achieve superior control over reaction parameters, leading to higher yields and purity of the target products. This method minimizes waste and improves sustainability in chemical manufacturing. The combination of these technologies exemplifies the potential for advanced process engineering to revolutionize chemical synthesis, providing a pathway for more efficient and environmentally friendly production methods. 🌱 We are proud to have contributed parts to this innovative study. Contact Manetco today to explore how our expertise in continuous flow mixers can optimize your chemical processes and drive efficiency in production. 🌐 #ChemicalEngineering #EnantioselectiveSynthesis #GreenChemistry #ContinuousFlowMixers #ChemicalManufacturing

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#Article Co-Culture of Glomerular Endothelial Cells and Podocytes in a Custom-Designed Glomerulus-on-a-Chip Model Improves the Filtration Barrier Integrity and Affects the Glomerular Cell Phenotype by Roland Brock, Wouter Verdurmen, Johan van der Vlag and Tom Nijenhuis https://lnkd.in/gGMxgyPg   #MDPI #cell #Biochemical #chip #biosensors #sensors #openaccess   #Abstract Crosstalk between glomerular endothelial cells and glomerular epithelial cells (podocytes) is increasingly becoming apparent as a crucial mechanism to maintain the integrity of the glomerular filtration barrier. However, in vitro studies directly investigating the effect of this crosstalk on the glomerular filtration barrier are scarce because of the lack of suitable experimental models. Therefore, we developed a custom-made glomerulus-on-a-chip model recapitulating the glomerular filtration barrier, in which we investigated the effects of co-culture of glomerular endothelial cells and podocytes on filtration barrier function and the phenotype of these respective cell types. The custom-made glomerulus-on-a-chip model was designed using soft lithography. The chip consisted of two parallel microfluidic channels separated by a semi-permeable polycarbonate membrane. The glycocalyx was visualized by wheat germ agglutinin staining and the barrier integrity of the glomerulus-on-a-chip model was determined by measuring the transport rate of fluorescently labelled dextran from the top to the bottom channel. The effect of crosstalk on the transcriptome of glomerular endothelial cells and podocytes was investigated via RNA-sequencing. Glomerular endothelial cells and podocytes were successfully cultured on opposite sides of the membrane in our glomerulus-on-a-chip model using a polydopamine and collagen A double coating. Barrier integrity of the chip model was significantly improved when glomerular endothelial cells were co-cultured with podocytes compared to monocultures of either glomerular endothelial cells or podocytes. Co-culture enlarged the surface area of podocyte foot processes and increased the thickness of the glycocalyx. RNA-sequencing analysis revealed the regulation of cellular pathways involved in cellular differentiation and cellular adhesion as a result of the interaction between glomerular endothelial cells and podocytes. We present a novel custom-made glomerulus-on-a-chip co-culture model and demonstrated for the first time using a glomerulus-on-a-chip model that co-culture affects the morphology and transcriptional phenotype of glomerular endothelial cells and podocytes. Moreover, we showed that co-culture improves barrier function as a relevant functional readout for clinical translation. This model can be used in future studies to investigate specific glomerular paracrine pathways and unravel the role of glomerular crosstalk in glomerular (patho) physiology.

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The FAST - Centre for Future Affordable Sustainable Therapy Development has launched a Handbook for ATMP Developers, offering essential guidance for researchers navigating the development and regulatory journey of Advanced Therapy Medicinal Products (#ATMPs). Saco de Visser (Scientific Director at FAST and Governor of #EATRIS_NL) comments: ”Access to ATMPs is critical for patients, as these innovative therapies offer transformative potential for conditions that current treatments cannot adequately address. However, the complex regulatory pathways and specific requirements can hinder timely, affordable and sustainable access. It's essential that we bridge these gaps, ensuring clarity for developers and fostering a healthcare system where patients can benefit from these groundbreaking advancements.” 👉 Find out more here: https://lnkd.in/drywnnnz

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Poster presented at #ASHG24 yesterday 'Detection of a pathogenic PRKN inversion by a novel DNA-RNA combined analysis of structural variants'. Poster in the link. Thanks to Willem Haagmans for presenting the key findings: Pathogenic PRKN inversion detected through combined DNA-RNA analysis Challenge: DNA or RNA analysis alone often provides an incomplete view of structural variants (SVs) Solution: SVDuo 😊 Do you want to learn more? https://lnkd.in/dwGzPxZV #rna #dna #multiomics

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Innovation in RNA isolation in dried blood samples at Universiteit Gent using Neoteryx Mitra microsampling devices by Trajan Scientific and Medical treated with GenTegraRNA-NEO stabilizing agent. Pre-treating the devices with this agent is designed to keep RNA stable in the blood samples for up to 7 days at ambient temperatures, without the need for cold shipping or storage. UGent researchers isolated RNA according to methods described in a Promega Corporation application note. #RNA #DNA GenTegra LLC #Mitra #VAMS #blood #microsampling #methods #appnote Read about the #RNA study here: https://hubs.la/Q02z8CYH0

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The future is now! Artificial intelligence (AI) emerged as a data-driven technique which is becoming increasingly relevant in exploring the full potential of cell therapy and personalized medicine. Through the integration of advanced sensor technology and AI assistance, the optimization of cell expansion processes is within reach. Read more about this and other possibilities with AI in our latest blogpost: https://lnkd.in/e4GEcpVk

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In this article on NMR in Clinical Research, researchers from Universiteit Leiden Medical Center used a combined approach with a targeted quantitative lipidomics platform and targeted lipoprotein analysis using a Bruker IVDr spectrometer* to examine lipidomic changes in Dutch South Asians (DSA) and Dutch white Caucasians with and without Type 2 diabetes mellitus (T2DM). They identified significant differences in lipid profiles between T2DM patients and controls, with DSA controls already showing a T2DM-prone lipid profile. Key findings include ethnicity-specific lipid markers which were linked to glycemic control and renal function in DSA-T2DM patients, suggesting potential personalized biomarkers. Read the article: https://lnkd.in/dFm9h3Gp *Research use only. Bruker #NMR instruments are not intended for use in clinical diagnostic procedures.

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𝘽𝙧𝙚𝙖𝙠𝙞𝙣𝙜 𝙉𝙚𝙬𝙨:Bioprex Medical 𝘀𝗲𝗰𝘂𝗿𝗲𝘀 𝗳𝘂𝗻𝗱𝗶𝗻𝗴 𝗳𝗼𝗿 𝗴𝗿𝗼𝘂𝗻𝗱𝗯𝗿𝗲𝗮𝗸𝗶𝗻𝗴 𝗮𝗻𝘁𝗶𝗯𝗮𝗰𝘁𝗲𝗿𝗶𝗮𝗹 𝗰𝗼𝗮𝘁𝗶𝗻𝗴 𝘁𝗲𝗰𝗵𝗻𝗼𝗹𝗼𝗴𝘆!🦠 Bioprex Medical, a Groningen-based biotech startup, has successfully closed a new financing round to advance its patented antibacterial coating technology. Over the coming year, Bioprex will focus on preclinical evaluations and expanding collaborations with medical device and implant manufacturers. 𝗞𝗲𝘆 𝗣𝗼𝗶𝗻𝘁𝘀: 𝗙𝘂𝗻𝗱𝗶𝗻𝗴: Led by Pharma Connect Capital and NV NOM. 𝗢𝗯𝗷𝗲𝗰𝘁𝗶𝘃𝗲:Further develop an antibacterial coating to prevent infections caused by medical devices and implants. 𝗙𝗼𝘂𝗻𝗱𝗲𝗱:2022 as a spin-off from the Zernike Institute for Advanced Materials at the University of Groningen. Bioprex's coating, using quaternary ammonium compounds, kills bacteria before they can adhere to surfaces, addressing a major healthcare issue. With over 4 million annual infections in Europe, this technology could greatly reduce infection rates and healthcare costs, especially as antibiotic resistance rises. Bioprex is now focusing on preclinical evaluations, starting with orthopedic implants like pins and screws, and plans to expand to catheters and other devices. 𝗡𝗲𝘅𝘁 𝘀𝘁𝗲𝗽𝘀: Bioprex will focus on preclinical evaluations, starting with orthopedic implants like pins and screws, with plans to expand to catheters and other devices. #dutchinnovation #biotech #startup #healthcare #innovation https://lnkd.in/dEuR8kDt

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Dive into the future of #Pathology with Sara Pires de Oliveira, Postdoc Researcher at the Netherlands Cancer Institute. In this enlightening lecture, the postdoctoral researcher in the Computational Pathology Group at the Netherlands Cancer Institute, shares essential insights on building high-quality datasets for computational pathology projects. With a focus on the foundational pathology data sources, such as whole slide images, Sara Oliveira offers practical advice on how to prepare these datasets for AI and machine learning applications. What’s in Store? - Tips on creating robust and accurate datasets for use in computational pathology. - Insights into the process of collecting and preparing whole slide images for AI. - An overview of challenges and best practices in dataset preparation for machine learning in pathology. - Real-world examples demonstrating the impact of high-quality data on AI-driven pathology. The integration of AI in pathology relies heavily on the quality of datasets. Don’t miss this chance to learn from an expert in the field and enhance your skills in computational pathology. Join Now the ESDIP Academy: https://lnkd.in/dfTmZqB8  #DigitalPathology #AIinMedicine #PathologyRevolution #HealthcareInnovation

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Synaffix BV today announces it has licensed its #ADC technology to BigHat Biosciences.   BigHat will combine Synaffix technology with its world-class machine learning #antibody design platform for the development of a new ADC pipeline program.     Under the terms of the agreement, BigHat will receive target-specific access to Synaffix’s late-clinical stage, site-specific ADC technology platform, which enables the transformation of antibodies into proprietary, best-in-class ADC products. BigHat will also gain access to Lonza’s end-to-end ADC offering. For more information on this exciting new collaboration, please read the full press release linked in the comments below. #ADCs #drugdevelopment #innovation #artificialintelligence #machinelearning

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Modulation of protein-protein interactions (#PPIs) with molecular glues is an emerging strategy in #drugdiscovery, offering potential solutions for targeting 'hard to drug' protein classes. Join us on June 18th for a Cytiva webinar where our scientist, Pim de Vink, will share his experience and discuss common trends with fellow drug discovery scientists. In his presentation Pim will outline a series of #biophysical #assay setups specifically developed for the screening and validation of new #molecularglues using a #fragment-based approach. Register here: https://cytiva.link/4f3de

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👀 More exciting news! The first article on IgMBRAZOR™ is published! 🤩 Scientists at Utrecht University and collaborators have described the use of online Size-Exclusion Chromatography (SEC) combined with Orbitrap-based Charge Detection Mass Spectrometry (CDMS) to perform real-time kinetic monitoring of pentameric IgM digestion by IgMBRAZOR! IgMBRAZOR is a unique IgM-specific protease that digests human IgM at one specific site below the CH2 domain in the heavy chain, generating homogeneous F(ab’)2 and Fc fragments. This novel enzyme enables middle-level analysis of the complex and high molecular weight human IgM, which facilitates IgM characterization during, for example, the development of vaccines, therapeutics, and diagnostics! 💉💊 Learn more about this cutting-edge research here ☞ https://lnkd.in/dd99UyUp #IgMBRAZOR #Biotechnology #MassSpectrometry #Protease #IgM #ResearchArticle #ScienceNews #VaccineDevelopment #Therapeutics #Diagnostics #Genovis

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