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Immunology news
Genetics
Researchers identify mutations that can lead to resistance to some chemotherapies
Investigators at Mass General Brigham have uncovered how resistance to chemotherapies may occur in some cancers. Researchers focused on a pathway that harnesses reactive oxygen species (ROS) to kill cancer cells. The study ...
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Oncology & Cancer
How melanoma and other tumors succeed in hiding and resisting immunotherapy
Cutaneous melanoma, the most aggressive form of skin cancer, is characterized by its accumulation of a large number of mutations. Although some of these alterations should be recognized as a threat by our defenses, melanomas ...
Mar 28, 2025
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Supercomputer uncovers immune system's secret to self-tolerance
A discovery published in Nature Immunology has shed light on why the immune system is less aggressive toward self-antigens, offering new opportunities to enhance cancer immunotherapy.
Mar 28, 2025
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Fatty acids promote immune suppression and therapy resistance in triple negative breast cancer, study shows
A new study published in the journal Immunity reveals a mechanism that allows triple negative breast cancer (TNBC) to develop resistance to therapy.
Mar 28, 2025
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Scientists uncover how TBK1 and IKKε prevent premature cell death and inflammation
New research from the Kennedy Institute has revealed how two important proteins, TBK1 and IKKε, play a crucial role in preventing premature cell death, which can lead to serious inflammation in the body. The findings are ...
Mar 28, 2025
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Understanding the immune response to Toxoplasma gondii, a persistent pathogen
Most humans have long-lived infections in various tissues—including in the nervous system—that typically do not result in disease. The microbes associated with these infections enter a latent stage during which they quietly ...
Mar 28, 2025
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Clinical trials show new antibody therapy offers long-lasting HIV control without daily medication
If the past four decades have taught us anything about HIV, it's to adjust our expectations—despite enormous progress in controlling the virus, no treatment can yet completely eradicate HIV once it has taken hold. But promising ...
Mar 28, 2025
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Nasal protein could aid in early COPD detection
Early diagnosis of COPD, chronic obstructive pulmonary disease, increases the quality of life of the patient and the efficacy of available treatments. Researchers at Karolinska Institutet have now shown that material from ...
Mar 28, 2025
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Researchers identify potential drug combinations to improve breast cancer treatment: Q&A with professor of pharmacology
Triple-negative breast cancer, an aggressive type of breast cancer, accounts for 10% of all breast cancer cases in the United States annually. CD8+ T cells that normally kill cancer cells often become exhausted and stop.
Mar 28, 2025
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A protective immune system cell disappears from a key form of fat, but only in those who are obese
The mammalian immune system is an evolutionary wonder. It's capable of recognizing and destroying cancer cells, and it can deploy armies of antibodies against viruses, bacteria, parasites and fungi.
Study establishes cell death as a driving force in glioblastoma
Glioblastoma, one of the most aggressive and lethal brain cancers, has a five-year survival rate of only 6.9%, according to the National Brain Tumor Society. While the relationship between glioblastoma and cell death, also ...
Mar 27, 2025
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Compelling data points to a single, unknown respiratory virus as cause of Kawasaki disease
Research from Stanley Manne Children's Research Institute at Ann & Robert H. Lurie Children's Hospital of Chicago strongly suggests that Kawasaki disease is caused by a single respiratory virus that is yet to be identified. ...
Mar 27, 2025
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Scientists discover immune cell networks driving deadly lung disease
Rutgers Health researchers have discovered that networks of misplaced immune cells drive an aggressive lung disease, potentially opening a path to new treatments for a condition that kills 80% of patients within a decade.
Mar 27, 2025
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Successful CAR-T cell therapy for end-stage multiple myeloma using advanced cellular product performed in Hong Kong
A clinical team has spearheaded the use of CAR-T cell therapy for blood cancers. The researchers recently treated the first myeloma patient with this therapy, resulting in a very good response without severe complications. ...
Mar 27, 2025
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After a heart attack, a boost in anti-inflammatory cells could promote healing
A scientific technique that rapidly increases the body's production of anti-inflammatory cells promotes healing from heart attacks in mice, according to a new study by investigators from the Smidt Heart Institute at Cedars-Sinai. ...
Mar 26, 2025
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mRNA-based COVID-19 vaccines train the 'long-term memory' of the immune system, study reveals
Researchers at the University of Cologne and University Hospital Cologne have determined that the novel mRNA-based COVID-19 vaccines not only induce acquired immune responses such as antibody production, but also cause persistent ...
Mar 26, 2025
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Potential 'molecular mimics' may be behind COVID-induced autoimmune disease
COVID infection has been linked to a higher risk of autoimmune disorders, including rheumatoid arthritis and type 1 diabetes. But why the virus might cause the body's immune system to go haywire remains unknown, making it ...
Mar 26, 2025
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How Zika virus knocks out our immune defenses
Zika virus and dengue virus are very close relatives. Both are mosquito-borne flaviviruses, and both specialize in infecting a host's dendritic cells.
Mar 25, 2025
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A crucial mechanism in immune response: NOTCH signaling pathway plays essential role in CD8⁺ T cell differentiation
Ten years of substantial work by Université de Montréal immunologist Nathalie Labrecque's team at the Montreal Clinical Research Institute (IRCM) and the Maisonneuve-Rosemont Hospital Research Center have shed new light ...
Mar 25, 2025
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Abundance of key immune cells may be influenced by estrogen and XX chromosomes
Women have a higher proportion of key immune cells between puberty and menopause, which may be linked to the sex hormone estrogen and explain why they are less susceptible to certain infectious diseases than men, according ...
Mar 25, 2025
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Fusing two immune system proteins leads to a new method of generating antibodies
The Food and Drug Administration has approved more than 100 monoclonal antibodies to treat a range of diseases. Other antibodies are used by physicians to diagnose conditions or by scientists to advance research projects.
Mar 25, 2025
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Neutrophils' mitochondrial sensing disrupted in lupus patients, study finds
Assistant Professor Andrew Monteith's lab in the Department of Microbiology is documenting how key immune cells detect infection and how that fails to happen in people with lupus.
Mar 25, 2025
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High-salt diet linked to depression: Protein IL-17A plays key role in mice study
A new study published in The Journal of Immunology found that a high-salt diet (HSD) induces depression-like symptoms in mice by driving the production of a protein called IL-17A. This protein has previously been identified ...
Mar 25, 2025
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Lupus-related antibody shows promise in enhancing cancer treatment efficacy
Yale scientists have discovered a promising way to trigger immune responses against certain tumors, using a lupus-related antibody that can slip, undetected, into "cold" tumors and flip on an immune response that has been ...
Mar 25, 2025
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Peacekeeper cells protect the body from autoimmunity during infection, research shows
During infections, the immune system needs to distinguish foreign antigens that are expressed by invading bacteria and viruses from self-antigens that are expressed by cells of the body. If not, the immune system can mistakenly ...
Mar 24, 2025
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