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Up on the tightrope: natural killer cell activation and inhibition
scientific article (publication date: May 2008)
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title
Up on the tightrope: natural killer cell activation and inhibition
(English)
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PubMed
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=18425106
retrieved
30 April 2017
author name string
Lanier LL
series ordinal
1
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PubMed
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=18425106
retrieved
30 April 2017
language of work or name
English
1 reference
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PubMed
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=18425106
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30 April 2017
publication date
May 2008
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PubMed
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=18425106
retrieved
30 April 2017
published in
Nature Immunology
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PubMed
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=18425106
retrieved
30 April 2017
volume
9
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PubMed
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=18425106
retrieved
30 April 2017
issue
5
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PubMed
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=18425106
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30 April 2017
page(s)
495-502
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PubMed
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=18425106
retrieved
30 April 2017
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Regulation of Ly49D/DAP12 signal transduction by Src-family kinases and CD45
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30 April 2017
Negative regulation of natural killer cell function by EAT-2, a SAP-related adaptor
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Requirement of homotypic NK-cell interactions through 2B4(CD244)/CD48 in the generation of NK effector functions
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NKG2D-DAP10 triggers human NK cell–mediated killing via a Syk-independent regulatory pathway
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Selective associations with signaling proteins determine stimulatory versus costimulatory activity of NKG2D
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30 April 2017
NKG2D recruits two distinct adapters to trigger NK cell activation and costimulation
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30 April 2017
Association of the X-linked lymphoproliferative disease gene product SAP/SH2D1A with 2B4, a natural killer cell-activating molecule, is dependent on phosphoinositide 3-kinase
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30 April 2017
UL16-binding proteins, novel MHC class I-related proteins, bind to NKG2D and activate multiple signaling pathways in primary NK cells
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2B4 (CD244)-mediated activation of cytotoxicity and IFN-gamma release in human NK cells involves distinct pathways
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30 April 2017
Activation of NK cell-mediated cytotoxicity by a SAP-independent receptor of the CD2 family
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30 April 2017
NTB-A [correction of GNTB-A], a novel SH2D1A-associated surface molecule contributing to the inability of natural killer cells to kill Epstein-Barr virus-infected B cells in X-linked lymphoproliferative disease
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2B4-mediated activation of human natural killer cells
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30 April 2017
NK cell inhibitory receptors prevent tyrosine phosphorylation of the activation receptor 2B4 (CD244)
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30 April 2017
DAP10 and DAP12 form distinct, but functionally cooperative, receptor complexes in natural killer cells
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30 April 2017
X-linked lymphoproliferative disease. 2B4 molecules displaying inhibitory rather than activating function are responsible for the inability of natural killer cells to kill Epstein-Barr virus-infected cells
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30 April 2017
An activating immunoreceptor complex formed by NKG2D and DAP10
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30 April 2017
Activation of NK cells and T cells by NKG2D, a receptor for stress-inducible MICA
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DAP12-mediated signal transduction in natural killer cells. A dominant role for the Syk protein-tyrosine kinase
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Identification of a novel signal transduction surface molecule on human cytotoxic lymphocytes
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DNA sequence analysis of NKG2, a family of related cDNA clones encoding type II integral membrane proteins on human natural killer cells
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Protein kinase C regulates expression and function of inhibitory killer cell Ig-like receptors in NK cells
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2B4 inhibits NK-cell fratricide
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Dysregulation of signaling pathways in CD45-deficient NK cells leads to differentially regulated cytotoxicity and cytokine production
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NKG2D-mediated signaling requires a DAP10-bound Grb2-Vav1 intermediate and phosphatidylinositol-3-kinase in human natural killer cells
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The adaptor protein 3BP2 binds human CD244 and links this receptor to Vav signaling, ERK activation, and NK cell killing
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Synergy among receptors on resting NK cells for the activation of natural cytotoxicity and cytokine secretion
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3 June 2018
Regulation of natural cytotoxicity by the adaptor SAP and the Src-related kinase Fyn.
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3 June 2018
The activating NKG2D receptor assembles in the membrane with two signaling dimers into a hexameric structure.
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3 June 2018
A requirement for CD45 distinguishes Ly49D-mediated cytokine and chemokine production from killing in primary natural killer cells
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3 June 2018
Convergence on a distinctive assembly mechanism by unrelated families of activating immune receptors.
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3 June 2018
Role for glycogen synthase kinase-3 in NK cell cytotoxicity and X-linked lymphoproliferative disease
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3 June 2018
Molecular basis for positive and negative signaling by the natural killer cell receptor 2B4 (CD244).
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3 June 2018
Engagement of NKG2D by cognate ligand or antibody alone is insufficient to mediate costimulation of human and mouse CD8+ T cells.
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Targeted disruption of the 2B4 gene in mice reveals an in vivo role of 2B4 (CD244) in the rejection of B16 melanoma cells.
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3 June 2018
Differential requirements for Vav proteins in DAP10- and ITAM-mediated NK cell cytotoxicity
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3 June 2018
Molecular dissection of 2B4 signaling: implications for signal transduction by SLAM-related receptors
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3 June 2018
2B4 acts as a non-major histocompatibility complex binding inhibitory receptor on mouse natural killer cells
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3 June 2018
Role of NKG2D signaling in the cytotoxicity of activated and expanded CD8+ T cells
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3 June 2018
Comparative analysis of human NK cell activation induced by NKG2D and natural cytotoxicity receptors
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3 June 2018
Vav1 dephosphorylation by the tyrosine phosphatase SHP-1 as a mechanism for inhibition of cellular cytotoxicity
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3 June 2018
Natural killer cell inhibitory receptors block actin cytoskeleton-dependent recruitment of 2B4 (CD244) to lipid rafts
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3 June 2018
The role of the NKG2D immunoreceptor in immune cell activation and natural killing
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3 June 2018
2B4 is constitutively associated with linker for the activation of T cells in glycolipid-enriched microdomains: properties required for 2B4 lytic function
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3 June 2018
Natural cytotoxicity uncoupled from the Syk and ZAP-70 intracellular kinases
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PubMed Central
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3 June 2018
Ubiquitination and degradation of Syk and ZAP-70 protein tyrosine kinases in human NK cells upon CD16 engagement.
1 reference
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PubMed Central
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3 June 2018
Patients with X-linked lymphoproliferative disease have a defect in 2B4 receptor-mediated NK cell cytotoxicity
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2669298
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3 June 2018
Immune inhibitory receptors
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PubMed Central
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retrieved
3 June 2018
Functional requirement for SAP in 2B4-mediated activation of human natural killer cells as revealed by the X-linked lymphoproliferative syndrome
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2669298
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3 June 2018
Characterization of inhibitory and stimulatory forms of the murine natural killer cell receptor 2B4.
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retrieved
3 June 2018
The Vav-Rac1 pathway in cytotoxic lymphocytes regulates the generation of cell-mediated killing
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2669298
retrieved
3 June 2018
Selective rejection of H-2-deficient lymphoma variants suggests alternative immune defence strategy.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2669298
retrieved
3 June 2018
Co-association of CD3 zeta with a receptor (CD16) for IgG Fc on human natural killer cells.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2669298
retrieved
3 June 2018
Analysis of Fc gamma RIII (CD16) membrane expression and association with CD3 zeta and Fc epsilon RI-gamma by site-directed mutation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2669298
retrieved
3 June 2018
Fc gamma receptor activation induces the tyrosine phosphorylation of both phospholipase C (PLC)-gamma 1 and PLC-gamma 2 in natural killer cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2669298
retrieved
3 June 2018
Inappropriate recruitment and activity by the Src homology region 2 domain-containing phosphatase 1 (SHP1) is responsible for receptor dominance in the SHIP-deficient NK cell
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2669298
retrieved
26 November 2018
Cutting edge: dominance by an MHC-independent inhibitory receptor compromises NK killing of complex targets
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2669298
retrieved
26 November 2018
Phospholipase C-gamma 2 is a critical signaling mediator for murine NK cell activating receptors
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2669298
retrieved
26 November 2018
Coordinated induction by IL15 of a TCR-independent NKG2D signaling pathway converts CTL into lymphokine-activated killer cells in celiac disease
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2669298
retrieved
26 November 2018
NKG2D triggers cytotoxicity in mouse NK cells lacking DAP12 or Syk family kinases.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2669298
retrieved
26 November 2018
SH2-containing inositol phosphatase (SHIP-1) transiently translocates to raft domains and modulates CD16-mediated cytotoxicity in human NK cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2669298
retrieved
26 November 2018
A novel function-associated molecule related to non-MHC-restricted cytotoxicity mediated by activated natural killer cells and T cells
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/18425106
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Cloning and characterization of the 2B4 gene encoding a molecule associated with non-MHC-restricted killing mediated by activated natural killer cells and T cells
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/18425106
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Vav1 Controls DAP10-Mediated Natural Cytotoxicity by Regulating Actin and Microtubule Dynamics
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/18425106
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Direct and indirect interactions of the cytoplasmic region of CD244 (2B4) in mice and humans with FYN kinase
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/18425106
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
NKG2D signaling is coupled to the interleukin 15 receptor signaling pathway
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/18425106
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Analysis of the molecular mechanism involved in 2B4-mediated NK cell activation: evidence that human 2B4 is physically and functionally associated with the linker for activation of T cells
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/18425106
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
ULBP1, 2, 3: novel MHC class I-related molecules that bind to human cytomegalovirus glycoprotein UL16, activate NK cells
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/18425106
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1038/NI1581
2 references
stated in
PubMed
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=18425106
retrieved
30 April 2017
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
671952
Dimensions Publication ID
1014028862
0 references
OpenCitations bibliographic resource ID
671952
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
671952
PMC publication ID
2669298
2 references
stated in
PubMed
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=18425106
retrieved
30 April 2017
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
671952
PubMed publication ID
18425106
2 references
stated in
PubMed
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=18425106
retrieved
30 April 2017
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
671952
ResearchGate publication ID
5427846
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