The gut-liver axis links the associations between serum carotenoids and non-alcoholic fatty liver in a 7.8-year prospective study

The biomarkers of the gut-liver axis, including the Ruminococcaceae and Veillonellaceae families, along with fecal and serum metabolites like medium-chain fatty acids, bile acids, carnitines, organic acids, and amino acids, provide mechanistic linkage the beneficial association of serum carotenoids and incidence/presence NAFLD.

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Effects of exercise and nutrition in improving sarcopenia in liver cirrhosis patients: a systematic review and meta-analysis

A combination of exercise and nutrition interventions significantly improved sarcopenia in patients with liver cirrhosis for 12 months. Skeletal muscle index and albumin levels are positively correlated with these strategies. Prevention of sarcopenia in these patients requires a healthy diet and regular exercise.

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Deciphering molecular crosstalk mechanisms between skeletal muscle atrophy and KRAS-mutant pancreatic cancer: a literature review

Comprehensive evidence updates the intricate crosstalk between KRAS-mutant PC and skeletal muscle atrophy, delineating the pathophysiological context essential for grasping sarcopenia and associated disorders. Thorough analysis enriches our knowledge of the complex causes of PC cachexia and sarcopenia and promotes the development of targeted therapeutic strategies.

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Liver venous deprivation (LVD) before extended hepatectomy: a French multicentric retrospective cohort

Post Hepatectomy Liver Failure (PHLF) remains a challenge for hepatectomy, and Liver Venous Deprivation (LVD) represent an effective option in situations where there is a risk of portal vein embolization (PVE) failure. This study aims to assess LVD feasibility, efficacy, and safety in a large, retrospective, French multicentric cohort.

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Comparative analysis of analgesic efficacy and functional recovery in open pancreaticoduodenectomy: a randomized controlled trial of local anesthetic wound infiltration, transversus abdominis plane block, and intramuscular electrical stimulation

Both four-quadrant transversus abdominis plane block and needle electrical twitch obtaining intramuscular stimulation showed greater effectiveness in reducing postoperative pain, requiring fewer analgesics, and enhancing functional recovery, including coughing ability and gait speed, after pancreaticoduodenectomy compared to local wound infiltration.

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Selective internal radiation therapy across Barcelona Clinic Liver Cancer (BCLC) stages of hepatocellular carcinoma: literature review

SIRT is a well-recognized endovascular treatment option for patients in intermediate and advanced HCC stage. However, in the recent years it has become a promising, safe and effective treatment even in selected patients at all BCLC stages of HCC with different advantages and clinical implications.

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Interviews with Outstanding Authors (2024)

In 2024, many HBSN authors make outstanding contributions to our journal. Their articles published with us have received very well feedback in the field and stimulate a lot of discussions and new insights among the peers.

Hereby, we would like to highlight some of our outstanding authors who have been making immense efforts in their research fields, with a brief interview of their unique perspective and insightful view as authors.

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Choline suppresses hepatocellular carcinoma progression by attenuating AMPK/mTOR-mediated autophagy via choline transporter SLC5A7 activation

Our study demonstrated that choline inhibited HCC malignant progression by suppressing AMPK/mTOR-mediated autophagy via SLC5A7 upregulation. In addition, choline worked synergistically with sorafenib to enhance its antitumor effect, which may provide a new strategy for HCC treatment in the future.

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Association of Pringle maneuver with postoperative recurrence and survival following hepatectomy for hepatocellular carcinoma: a multicenter propensity score and competing-risks regression analysis

Using two propensity score methods and competing-risk regression analysis, the effect of Pringle maneuver on long-term prognosis of hepatocellular carcinoma after hepatectomy was clarified. Not applying the Pringle maneuver during hepatectomy was independently associated with lower cumulative recurrence rate and cancer-specific mortality.

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A single center analysis of long-term outcomes and survival related risk factors in liver retransplantation

Liver retransplantation with living donor graft in hands of experienced team with refined technique showed optimal long-term outcome and it is irrelevant of the timing of retransplantation. Long warm ischemia time and intraoperative massive blood transfusion negatively impact patient’s survival.

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Impact of preoperative chemotherapy on surgical results in 139 patients with locally advanced pancreatic cancer

Preoperative chemotherapy enables resectability of initially unresectable patients with LAPC without increasing perioperative mortality and morbidity. The combination of preoperative chemotherapy and consecutive surgery improves recurrence-free and overall survival in a real-world data set.

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Pathologic assessment of hepatocellular carcinoma in the era of immunotherapy: a narrative review

This review summarized the research progress of pathologic assessment related to immunotherapy of hepatocellular carcinoma. A precise histological evaluation of specimens underwent immunotherapy and predictive biomarkers of immunotherapy should be highly focused on for the pathologists.

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3D laparoscopic anatomical hepatectomy guided by 2D real-time indocyanine green fluorescence imaging for hepatocellular carcinoma

We propose a new procedure, 3D laparoscopic anatomical hepatectomy (LAH) with 2D real-time ICG (r-ICG) guidance for HCC treatment. In this procedure, the advantages of two techniques, 3D laparoscopy and 2D r-ICG guidance, were combined so that LAH might be performed with more precision.

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A combined pre- and intra-operative nomogram in evaluation of degrees of liver cirrhosis predicts post-hepatectomy liver failure: a multicenter prospective study

The multicenter prospective study demonstrated that either preoperative CSS or intra-operative DSM was closely correlated with histopathological stages of cirrhosis. Furthermore, high level of CSS or DSM indicated the risks of PHLF, and the nomograms including these two parameters can effectively predict PHLF.

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Clinical and molecular heterogeneity associated with tumor sidedness in colorectal liver metastasis: a multicenter propensity cohort study

The clinicopathological features, underlying molecular profiles, and drivers of left-sided colorectal liver metastasis differ from those of right-sided disease. Standardized, screening, diagnostic, and therapeutic strategies are required to optimize outcomes.

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Physical activity decreases in patients on the liver transplant waiting list and influences postoperative outcome—a prospective cohort study

Over time, there is a significant decrease of moderate physical activity (MPA) after week 40 on the wait list for liver transplantation (LT). Female patients and patients receiving nutritional support had an increase in MPA. Reduced MPA significantly associated with adverse outcome post-LT.

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Evaluation of the economic impact of the robotic approach in major and postero-superior segment liver resections: a multicenter retrospective analysis

Despite higher intraoperative expenses compared to OLS, RLS demonstrated lower overall postoperative costs, supporting its potential cost-effectiveness. The evolving robotic marketplace is expected to reduce RLS costs, further contributing to its favorability. This emphasizes the need for ongoing evaluations of technological advancements and training programs.

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Glutamatergic neurons in the paraventricular nucleus of the hypothalamus participate in the regulation of visceral pain induced by pancreatic cancer in mice

Targeting glutamatergic neurons in the PVN effectively alleviates visceral pain in pancreatic cancer in mice, thereby presenting a novel target and treatment modality for the clinical management of pancreas-related pain.

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Molecular profiling and patient selection for the multimodal approaches for patients with resectable colorectal liver metastases

Many clinical variables have guided patient selection and surgical timing for the treatment of resectable colorectal liver metastases, coactively using surgery and systemic treatment. This review explores forthcoming improvements in molecular and genetic profiling as promising tools for patient selection in a more tailored approach.

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Insights from Seoul National University Hospital’s experience: a systematic review of pure laparoscopic donor hepatectomy progression

The article highlights the progression of pure laparoscopic donor hepatectomy (PLDH) at Seoul National University Hospital, encompassing full right and left hepatectomies. It emphasizes the safety, feasibility, and expanded selection criteria for donors, leading to a shift from open surgery to pure laparoscopic procedures in donor hepatectomy and even in liver transplantation.

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International consensus guidelines on robotic pancreatic surgery in 2023

This international consensus guidelines on robotic pancreatic surgery (RPS) summarize the latest RPS literature, bringing together the opinions and recommendations of 29 Eastern and Western experts on 19 clinical issues. These recommendations offer comprehensive advice on indications, safety, and efficacy of different types of RPS.

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Grading severity of microscopic vascular invasion was independently associated with recurrence and survival following hepatectomy for solitary hepatocellular carcinoma

Grading severity of microscopic vascular invasion (MVI) was independently associated with recurrence-free survival (RFS) and overall survival (OS) following hepatectomy for solitary hepatocellular carcinoma (HCC).

Enhanced surveillance for recurrence and potentially adjuvant therapy may be considered for patients with MVI, especially individuals with more severe MVI grading (M2).

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Reviewer of the Month (2024)

In 2024, HBSN reviewers continue to make outstanding contributions to the peer review process. They demonstrated professional effort and enthusiasm in their reviews and provided comments that genuinely help the authors to enhance their work.

Hereby, we would like to highlight some of our outstanding reviewers, with a brief interview of their thoughts and insights as a reviewer. Allow us to express our heartfelt gratitude for their tremendous effort and valuable contributions to the scientific process.

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