Raphael Schatz 🧡

Raphael Schatz 🧡

Strasbourg et périphérie
3 k abonnés + de 500 relations

À propos

Depuis longtemps, je cherche mon épanouissement professionnel.
Je me suis rendu…

Services

Expérience

  • Graphique JobTaste
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    Strasbourg, Grand Est, France

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    Strasbourg, Grand Est, France

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    Grand Est, France

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    La Rochelle, Nouvelle-Aquitaine, France

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    La Rochelle et périphérie

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    La Rochelle et périphérie

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    Région de Strasbourg, France

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    Paris, France

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    Strasbourg, France

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    Strasbourg, France

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    Montreal, Canada

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    Région de Strasbourg, France

Formation

Licences et certifications

Publications

  • The challenge of gene therapy for neurological diseases: strategies and tools to achieve efficient delivery to the central nervous system

    Human Gene Therapy

    For more than ten years, gene therapy for neurological diseases has experienced intensive research growth and more recently therapeutic interventions for multiple indications. Beneficial results in several phase 1/2 clinical studies, together with improved vector technology have advanced gene therapy for the central nervous system (CNS) in a new era of development. While most initial strategies have focused on orphan genetic diseases, such as lysosomal storage diseases, more complex and…

    For more than ten years, gene therapy for neurological diseases has experienced intensive research growth and more recently therapeutic interventions for multiple indications. Beneficial results in several phase 1/2 clinical studies, together with improved vector technology have advanced gene therapy for the central nervous system (CNS) in a new era of development. While most initial strategies have focused on orphan genetic diseases, such as lysosomal storage diseases, more complex and widespread conditions like Alzheimer’s disease, Parkinson’s disease, epilepsy or chronic pain are increasingly targeted for gene therapy. Increasing numbers of applications and patients to be treated will require improving and simplifying gene therapy protocols to make them accessible to the largest number of affected people. While vectors and manufacturing are a major field of academic research and industrial development, there is a growing need to improve, standardize and simplify delivery methods. Delivery is the major issue for CNS therapies in general, and particularly for gene therapy. The blood brain barrier restricts the passage of vectors; and strategies to bypass this obstacle are a central focus of research. Here, we present the different ways that can be used to deliver gene therapy products to the CNS. We focus on results obtained in large animals that have allowed the transfer of protocols to human patients and have resulted in the generation of clinical data. We discuss the different routes of administration, their advantages and their limitations. We describe techniques, equipment and protocols and how they should be selected for safe delivery and improved efficiency for the next generation of gene therapy trials for CNS diseases.

    Autres auteurs
    Voir la publication

Projets

  • No Crunch Game Jam - Strasbourg Games Community : Sombre Taverne

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    🎮 https://fermeaux.itch.io/sombre-taverne

    💡 Game jam - hackathon de développement d'un jeu vidéo en 48h

    🏆 Prix pour l'univers

    ⚙️ Participation en tant que Game Designer

    Autres créateurs
  • Hacking Health Camp 2023 : Projet #39 - Salvia

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    🏆 Prix SML, délivré par le Dr. Thierry Ressel du Syndicat des Médecins Libéraux

    🚀 Hacking Health Camp #10 - 24 au 26 mars 2023 : hackathon de 50h pour développer un prototype sur un projet d'innovation en santé

    💊 Projet #39 - Salvia : application web qui facilite la prise de décision pour la prescription et la délivrance de médicaments

    ⚙️ Participation en tant que pharmacien et néo-entrepreneur

    🎙️ Pitch final : https://www.youtube.com/watch?v=HApuGeCQ9BU&t=3595s

    Autres créateurs
    Voir le projet
  • Global Game Jam 2023 : ChronoJumper

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    🎮 https://fermeaux.itch.io/chrono-jumper

    💡 Game jam - hackathon de développement d'un jeu vidéo en 48h

    🏆 Prix technique

    ⚙️ Participation en tant que Level Designer et Playtester

    Autres créateurs

Prix et distinctions

  • Scholarship : Initiative of Excellence (IdEx)

    Strasbourg University, France

    6-month funded research internship in fundamental Neuroscience in Montreal

  • Scholarship : BMI Grand Est

    Grand Est region, France

    6-month funded research internship in fundamental Neuroscience in Montreal

Langues

  • French

    Bilingue ou langue natale

  • English

    Capacité professionnelle complète

  • German

    Compétence professionnelle limitée

  • Spanish

    Notions

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