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Da Silva Filho, J. et al. (2024) A spatially resolved single-cell lung atlas integrated with clinical and blood signatures distinguishes COVID-19 disease trajectories. Science Translational Medicine, 16(764), eadk9149. (doi: 10.1126/scitranslmed.adk9149) (PMID:39259811)
Khalaf, A. et al. (2024) Nutrient-sensitizing drug repurposing screen identifies lomerizine as a mitochondrial metabolism inhibitor of chronic myeloid leukemia. Science Translational Medicine, 16(751), eadi5336. (doi: 10.1126/scitranslmed.adi5336) (PMID:38865484)
Sturgeon, J. P. et al. (2024) Inflammation and epithelial repair predict mortality, hospital readmission, and growth recovery in complicated severe acute malnutrition. Science Translational Medicine, 16(736), (doi: 10.1126/scitranslmed.adh0673) (PMID:38416844) (PMCID:PMC7615785)
Allen, N. E. et al. (2024) Prospective study design and data analysis in UK Biobank. Science Translational Medicine, 16(729), eadf4428. (doi: 10.1126/scitranslmed.adf4428) (PMID:38198570)
Hinchcliffe, J. K. et al. (2024) Rapid-acting antidepressant drugs modulate affective bias in rats. Science Translational Medicine, 16(729), eadi2403. (doi: 10.1126/scitranslmed.adi2403) (PMID:38198569) (PMCID:PMC7615567)
O’Sullivan, E. D. et al. (2023) Indian Hedgehog release from TNF activated renal epithelia drives local and remote organ fibrosis. Science Translational Medicine, 15(698), eabn07. (doi: 10.1126/scitranslmed.abn0736) (PMID:37256934)
Proietti, T., O’Neill, C., Gerez, L. , Cole, T., Mendelowitz, S., Nuckols, K., Hohimer, C., Lin, D., Paganoni, S. and Walsh, C. (2023) Restoring arm function with a soft robotic wearable for individuals with amyotrophic lateral sclerosis. Science Translational Medicine, 15(681), eadd15. (doi: 10.1126/scitranslmed.add1504) (PMID:36724237)
Cohen, J. M., Okumu, F. and Moonen, B. (2022) The fight against malaria: Diminishing gains and growing challenges. Science Translational Medicine, 14(651), (doi: 10.1126/scitranslmed.abn3256) (PMID:35767649)
Williams, S. A. et al. (2022) A proteomic surrogate for cardiovascular outcomes that is sensitive to multiple mechanisms of change in risk. Science Translational Medicine, 14(639), eabj9625. (doi: 10.1126/scitranslmed.abj9625) (PMID:35385337)
Maher, M. C. et al. (2022) Predicting the mutational drivers of future SARS-CoV-2 variants of concern. Science Translational Medicine, 14(633), eabk3445. (doi: 10.1126/scitranslmed.abk3445) (PMID:35014856) (PMCID:PMC8939770)
Swanson, P. A. et al. (2021) AZD1222/ChAdOx1 nCoV-19 vaccination induces a polyfunctional spike protein–specific T H 1 response with a diverse TCR repertoire. Science Translational Medicine, 13(620), eabj7211. (doi: 10.1126/scitranslmed.abj7211) (PMID:34591596)
Ianniciello, A. et al. (2021) ULK1 inhibition promotes oxidative stress–induced differentiation and sensitizes leukemic stem cells to targeted therapy. Science Translational Medicine, 13(613), eabd5016. (doi: 10.1126/scitranslmed.abd5016) (PMID:34586834)
Liu, Q. et al. (2021) Loss of TGFβ signaling increases alternative end-joining DNA repair that sensitizes to genotoxic therapies across cancer types. Science Translational Medicine, 13(580), eabc4465. (doi: 10.1126/scitranslmed.abc4465) (PMID:33568520)
Nguyen, E., Lim, G., Ding, H., Hachisuka, J. , Ko, M.-C. and Ross, S. E. (2021) Morphine acts on spinal dynorphin neurons to cause itch through disinhibition. Science Translational Medicine, 13(579), eabc3774. (doi: 10.1126/scitranslmed.abc3774) (PMID:33536279)
Prihandoko, R. et al. (2020) Pathophysiological regulation of lung function by the free fatty acid receptor FFA4. Science Translational Medicine, 12(557), eaaw9009. (doi: 10.1126/scitranslmed.aaw9009) (PMID:32817367)
Bryden, S. R. et al. (2020) Pan-viral protection against arboviruses by activating skin macrophages at the inoculation site. Science Translational Medicine, 12(527), eaax2421. (doi: 10.1126/scitranslmed.aax2421) (PMID:31969486)
Forbes, S. et al. (2020) Human umbilical cord perivascular cells improve human pancreatic islet transplant function by increasing vascularization. Science Translational Medicine, 12(526), eaan5907. (doi: 10.1126/scitranslmed.aan5907) (PMID:31941825)
Gorgoraptis, N. et al. (2019) In vivo detection of cerebral tau pathology in long-term survivors of traumatic brain injury. Science Translational Medicine, 11(508), eaaw1993. (doi: 10.1126/scitranslmed.aaw1993)
Dantzler, K. W. et al. (2019) Naturally acquired immunity against immature Plasmodium falciparum gametocytes. Science Translational Medicine, 11(495), eaav3963. (doi: 10.1126/scitranslmed.aav3963) (PMID:31167926) (PMCID:PMC6653583)
Abraham, A. C. et al. (2019) Targeting the NF-κB signaling pathway in chronic tendon disease. Science Translational Medicine, 11(481), eaav4319. (doi: 10.1126/scitranslmed.aav4319) (PMID:30814338) (PMCID:PMC6534967)
Scott, N. A. et al. (2018) Antibiotics induce sustained dysregulation of intestinal T cell immunity by perturbing macrophage homeostasis. Science Translational Medicine, 10(464), eaao4755. (doi: 10.1126/scitranslmed.aao4755) (PMID:30355800) (PMCID:PMC6548564)
Bird, T. G. et al. (2018) TGFβ inhibition restores a regenerative response in acute liver injury by suppressing paracrine senescence. Science Translational Medicine, 10(454), eaan1230. (doi: 10.1126/scitranslmed.aan1230) (PMID:30111642) (PMCID:PMC6420144)
Rajani, R. M. et al. (2018) Reversal of endothelial dysfunction reduces white matter vulnerability in cerebral small vessel disease in rats. Science Translational Medicine, 10(448), eaam9507. (doi: 10.1126/scitranslmed.aam9507) (PMID:29973407)
Lee, H. J., Georgiadou, A., Walther, M., Nwakanma, D., Stewart, L. B., Levin, M., Otto, T. D. , Conway, D. J., Coin, L. J. and Cunnington, A. J. (2018) Integrated pathogen load and dual transcriptome analysis of systemic host-pathogen interactions in severe malaria. Science Translational Medicine, 10(447), eaar3619. (doi: 10.1126/scitranslmed.aar3619) (PMID:29950443)
Kruspig, B. et al. (2018) The ERBB network facilitates KRAS-driven lung tumorigenesis. Science Translational Medicine, 10(446), eaao2565. (doi: 10.1126/scitranslmed.aao2565) (PMID:29925636) (PMCID:PMC6881183)
Strnadel, J. et al. (2018) Survival of syngeneic and allogeneic iPSC–derived neural precursors after spinal grafting in minipigs. Science Translational Medicine, 10(440), eaam6651. (doi: 10.1126/scitranslmed.aam6651) (PMID:29743351)
Fard, M. K. et al. (2017) BCAS1 expression defines a population of early myelinating oligodendrocytes in multiple sclerosis lesions. Science Translational Medicine, 9(419), eaam7816. (doi: 10.1126/scitranslmed.aam7816) (PMID:29212715)
Kirk, J. A., Gebhart, D., Buckley, A. M., Lok, S., Scholl, D., Douce, G. R. , Govoni, G. R. and Fagan, R. P. (2017) New class of precision antimicrobials redefines role of Clostridium difficile S-layer in virulence and viability. Science Translational Medicine, 9(406), eaah6813. (doi: 10.1126/scitranslmed.aah6813) (PMID:28878013) (PMCID:PMC5603275)
Vennin, C. et al. (2017) Transient tissue priming via ROCK inhibition uncouples pancreatic cancer progression, sensitivity to chemotherapy, and metastasis. Science Translational Medicine, 9(384), eaai8504. (doi: 10.1126/scitranslmed.aai8504) (PMID:28381539) (PMCID:PMC5777504)
Weinberger, F. et al. (2016) Cardiac repair in guinea pigs with human engineered heart tissue from induced pluripotent stem cells. Science Translational Medicine, 8(363), 363ra148-363ra148. (doi: 10.1126/scitranslmed.aaf8781) (PMID:27807283)
Scott, R. A. et al. (2016) A genomic approach to therapeutic target validation identifies a glucose-lowering GLP1R variant protective for coronary heart disease. Science Translational Medicine, 8(341), 341ra76. (doi: 10.1126/scitranslmed.aad3744) (PMID:27252175)
Seo, B. R. et al. (2015) Obesity-dependent changes in interstitial ECM mechanics promote breast tumorigenesis. Science Translational Medicine, 7(301), 301ra130. (doi: 10.1126/scitranslmed.3010467) (PMID:26290412) (PMCID:PMC4837896)
van den Driesche, S. et al. (2015) Prolonged exposure to acetaminophen reduces testosterone production by the human fetal testis in a xenograft model. Science Translational Medicine, 7(288), 288ra80. (doi: 10.1126/scitranslmed.aaa4097) (PMID:25995226)
Kundu, P. et al. (2015) An EphB-Abl signaling pathway is associated with intestinal tumor initiation and growth. Science Translational Medicine, 7(281), 281ra44. (doi: 10.1126/scitranslmed.3010567) (PMID:25834110)
Joice, R. et al. (2014) Plasmodium falciparum transmission stages accumulate in the human bone marrow. Science Translational Medicine, 6(244), 244re5. (doi: 10.1126/scitranslmed.3008882) (PMID:25009232) (PMCID:PMC4175394)
Cooley, B.C. et al. (2014) TGF- signaling mediates endothelial-to-mesenchymal transition (EndMT) during vein graft remodeling. Science Translational Medicine, 6(227), 227ra34. (doi: 10.1126/scitranslmed.3006927)
Pasricha, S.-R. et al. (2014) Expression of the iron hormone hepcidin distinguishes different types of anemia in African children. Science Translational Medicine, 6(235), 235re3. (doi: 10.1126/scitranslmed.3008249) (PMID:24807559)
Klein, J. et al. (2013) Fetal urinary peptides to predict postnatal outcome of renal disease in fetuses with posterior urethral valves(PUV). Science Translational Medicine, 5(198), 198ra106. (doi: 10.1126/scitranslmed.3005807)
Pullamsetti, S. S. et al. (2011) The role of dimethylarginine dimethylaminohydrolase in idiopathic pulmonary fibrosis. Science Translational Medicine, 3(87), 87ra53. (doi: 10.1126/scitranslmed.3001725) (PMID:21677199)
Mischak, H. et al. (2010) Recommendations for Biomarker Identification and Qualification in Clinical Proteomics. Science Translational Medicine, 2(46), 46ps42--. (doi: 10.1126/scitranslmed.3001249)