2024

Singh, S. P. et al. (2024) The TGF-β mimic TGM4 achieves cell specificity through combinatorial surface co-receptor binding. EMBO Reports, (doi: 10.1038/s44319-024-00323-2) (Early Online Publication)

Rekima, A. et al. (2024) Colostrum is required for the postnatal ontogeny of small intestine innate lymphoid type 2 cells and successful anti‐helminth defences. Allergy, 79(8), pp. 2247-2251. (doi: 10.1111/all.16054) (PMID:38348877)

Redgrave, R. E., Singh, E., Tual-Chalot, S., Park, C., Hall, D., Bennaceur, K., Smyth, D. J. , Maizels, R. M. , Spyridopoulos, I. and Arthur, H. M. (2024) Exogenous transforming growth factor-β1 and its helminth-derived mimic attenuate the heart's inflammatory response to ischemic injury and reduce mature scar size. American Journal of Pathology, 194(4), pp. 562-573. (doi: 10.1016/j.ajpath.2023.09.014) (PMID:37832870)

2023

Smyth, D. J. , White, M. P.J., Johnston, C. J.C., Donachie, A.-M., Campillo Poveda, M. , McSorley, H. J. and Maizels, R. M. (2023) Protection from T cell-dependent colitis by the helminth-derived immunomodulatory mimic of transforming growth factor-ß, Hp-TGM. Discovery Immunology, 2(1), kyad001. (doi: 10.1093/discim/kyad001) (PMID:36855464) (PMCID:PMC9958376)

2022

Chauché, C. , Rasid, O., Donachie, A. M., McManus, C. M., Löser, S., Campion, T., Richards, J., Smyth, D. J. , McSorley, H. J. and Maizels, R. M. (2022) Suppression of airway allergic eosinophilia by Hp-TGM, a helminth mimic of TGF-β. Immunology, 167(2), pp. 197-211. (doi: 10.1111/imm.13528) (PMID:35758054) (PMCID:PMC9885513)

Mukundan, A., Byeon, C.-H., Hinck, C. S., Cunningham, K. , Campion, T., Smyth, D. J. , Maizels, R. M. and Hinck, A. P. (2022) Convergent evolution of a parasite-encoded complement control protein-scaffold to mimic binding of mammalian TGF-ß to its receptors, TßRI and TßRII. Journal of Biological Chemistry, 298(6), 101994. (doi: 10.1016/j.jbc.2022.101994) (PMID:35500648) (PMCID:PMC9163516)

Varyani, F. et al. (2022) The IL-25-dependent tuft cell circuit driven by intestinal helminths requires macrophage migration inhibitory factor (MIF). Mucosal Immunology, 15(6), pp. 1243-1256. (doi: 10.1038/s41385-022-00496-w) (PMID:35288645) (PMCID:PMC9705247)

2021

Cook, L. et al. (2021) Induction of stable human FOXP3 + Tregs by a parasite‐derived TGF‐β mimic. Immunology and Cell Biology, 99(8), pp. 833-847. (doi: 10.1111/imcb.12475) (PMID:33929751)

White, M. P.J., Smyth, D. J. , Cook, L., Ziegler, S. F., Levings, M. K. and Maizels, R. M. (2021) The parasite cytokine mimic Hp-TGM potently replicates the regulatory effects of TGF-β on murine CD4+ T cells. Immunology and Cell Biology, 99(8), pp. 848-864. (doi: 10.1111/imcb.12479) (PMID:33988885) (PMCID:PMC9214624)

2019

Filbey, K. J. et al. (2019) Macrophage migration inhibitory factor (MIF) is essential for Type 2 effector cell immunity to an intestinal helminth parasite. Frontiers in Immunology, 10, 2375. (doi: 10.3389/fimmu.2019.02375) (PMID:31708913) (PMCID:PMC6821780)

Minutti, C. M. et al. (2019) A macrophage-pericyte axis directs tissue restoration via Amphiregulin-induced transforming growth factor beta activation. Immunity, 50(3), 645-654.e6. (doi: 10.1016/j.immuni.2019.01.008) (PMID:30770250) (PMCID:PMC6436929)

2018

Smyth, D. J. et al. (2018) TGF-β mimic proteins form an extended gene family in the murine parasite Heligmosomoides polygyrus. International Journal for Parasitology, 48(5), pp. 379-385. (doi: 10.1016/j.ijpara.2017.12.004) (PMID:29510118) (PMCID:PMC5904571)

Bull, T., Corley, A., Smyth, D. J. , McMillan, D. J., Dunster, K. R. and Fraser, J. F. (2018) Extracorporeal membrane oxygenation line-associated complications: in vitro testing of cyanoacrylate tissue adhesive and securement devices to prevent infection and dislodgement. Intensive Care Medicine Experimental, 6, 6. (doi: 10.1186/s40635-018-0171-8)

Mair, I., Zandee, S. E. J., Toor, I. S., Saul, L., McPherson, R. C., Leech, M. D., Smyth, D. J. , O’Connor, R. A., Henderson, N. C. and Anderton, S. M. (2018) A context-dependent role for αv integrins in regulatory T cell accumulation at sites of inflammation. Frontiers in Immunology, 9, 264. (doi: 10.3389/fimmu.2018.00264)

2017

Johnston, C. J.C. et al. (2017) A structurally distinct TGF-β mimic from an intestinal helminth parasite potently induces regulatory T cells. Nature Communications, 8, 1741. (doi: 10.1038/s41467-017-01886-6) (PMID:29170498) (PMCID:PMC5701006)

Osbourn, M. et al. (2017) HpARI protein secreted by a helminth parasite suppresses interleukin-33. Immunity, 47(4), 739-751.e5. (doi: 10.1016/j.immuni.2017.09.015) (PMID:29045903) (PMCID:PMC5655542)

2016

Duffin, R. et al. (2016) Prostaglandin E2 constrains systemic inflammation through an innate lymphoid cell-IL-22 axis. Science, 351(6279), pp. 1333-1338. (doi: 10.1126/science.aad9903) (PMID:26989254)

Gerbe, F. et al. (2016) Intestinal epithelial tuft cells initiate type 2 mucosal immunity to helminth parasites. Nature, 529(7585), pp. 226-230. (doi: 10.1038/nature16527) (PMID:26762460)

Johnston, C. J.C., Smyth, D. J. , Dresser, D. W. and Maizels, R. M. (2016) TGF-β in tolerance, development and regulation of immunity. Cellular Immunology, 299, pp. 14-22. (doi: 10.1016/j.cellimm.2015.10.006) (PMID:26617281) (PMCID:PMC4711336)

2015

Johnston, C. J.C., Robertson, E., Harcus, Y., Grainger, J. R., Coakley, G., Smyth, D. J. , McSorley, H. J. and Maizels, R. (2015) Cultivation of Heligmosomoides polygyrus: an immunomodulatory nematode parasite and its secreted products. Journal of Visualized Experiments(98), e52412. (doi: 10.3791/52412) (PMID:25867600) (PMCID:PMC4401400)

2014

Smyth, D. J. , Shera, J., Bauer, M. J., Cameron, A., McNeilly, C. L., Sriprakash, K. S. and McMillan, D. J. (2014) Conjugative transfer of ICESde3396 between three β-hemolytic streptococcal species. BMC Research Notes, 7(1), 521. (doi: 10.1186/1756-0500-7-521)

Maizels, R.M. , McSorley, H.J. and Smyth, D.J. (2014) Helminths in the hygiene hypothesis: sooner or later? Clinical and Experimental Immunology, 177(1), pp. 38-46. (doi: 10.1111/cei.12353) (PMID:24749722) (PMCID:PMC4089153)

Smyth, D. , Cameron, A., Davies, M. R., McNeilly, C., Hafner, L., Sriprakash, K. S. and McMillan, D. J. (2014) DrsG from Streptococcus dysgalactiae subsp. equisimilis inhibits the antimicrobial peptide LL-37. Infection and Immunity, 82(6), pp. 2337-2344. (doi: 10.1128/IAI.01411-13) (PMID:24664506) (PMCID:PMC4019180)

2013

Ferreira, I. et al. (2013) Hookworm excretory/secretory products induce interleukin-4 (IL-4)+IL-10+CD4+T cell responses and suppress pathology in a mouse model of colitis. Infection and Immunity, 81(6), pp. 2104-2111. (doi: 10.1128/IAI.00563-12) (PMID:23545299) (PMCID:PMC3676036)

2012

Simonova, G., Rickard, C.M., Dunster, D.M., Smyth, D.J. and McMillan, D. (2012) Cyanoacrylate tissue adhesives--effective securement technique for intravascular catheters: in vitro testing of safety and feasibility. Anaesthesia and Intensive Care, 40(3), pp. 460-466. (PMID:22577911)

2010

Huang, S. C.-C., Chan, D. T. Y., Smyth, D. J. , Ball, G., Gounaris, K. and Selkirk, M. E. (2010) Activation of Nippostrongylus brasiliensis infective larvae is regulated by a pathway distinct from the hookworm Ancylostoma caninum. International Journal for Parasitology, 40(14), pp. 1619-1628. (doi: 10.1016/j.ijpara.2010.06.004) (PMID:20654619)

Glanfield, A., McManus, D. P., Smyth, D. J. , Lovas, E. M., Loukas, A., Gobert, G. N. and Jones, M. K. (2010) A cytochrome b561 with ferric reductase activity from the parasitic blood fluke, Schistosoma japonicum. PLoS Neglected Tropical Diseases, 4(11), e884. (doi: 10.1371/journal.pntd.0000884) (PMID:21103361) (PMCID:PMC2982821)

2008

Mulvenna, J., Hamilton, B., Nagaraj, S. H., Smyth, D. , Loukas, A. and Gorman, J. J. (2008) Proteomics analysis of the excretory/secretory component of the blood-feeding stage of the hookworm, Ancylostoma caninum. Molecular and Cellular Proteomics, 8(1), pp. 109-121. (doi: 10.1074/mcp.M800206-MCP200) (PMID:18753127)

2007

Pearson, M.S., McManus, D.P., Smyth, D.J. , Jones, M.K., Sykes, A.M. and Loukas, A. (2007) Cloning and characterization of an orphan seven transmembrane receptor from Schistosoma mansoni. Parasitology, 134(14), pp. 2001-2008. (doi: 10.1017/S0031182007003393) (PMID:17714602) (PMCID:PMC2753299)

2006

Tran, M. H., Pearson, M. S., Bethony, J. M., Smyth, D. J. , Jones, M. K., Duke, M., Don, T. A., McManus, D. P., Correa-Oliveira, R. and Loukas, A. (2006) Tetraspanins on the surface of Schistosoma mansoni are protective antigens against schistosomiasis. Nature Medicine, 12(7), pp. 835-840. (doi: 10.1038/nm1430) (PMID:16783371)

Smyth, D. J. , Glanfield, A., McManus, D. P., Hacker, E., Blair, D., Anderson, G. J. and Jones, M. K. (2006) Two isoforms of a divalent metal transporter (DMT1) in Schistosoma mansoni suggest a surface-associated pathway for iron absorption in schistosomes. Journal of Biological Chemistry, 281(4), pp. 2242-2248. (doi: 10.1074/jbc.M511148200) (PMID:16267047) (PMCID:PMC1459476)

Rosenzvit, M. C., Zhang, W., Motazedian, H., Smyth, D. , Pearson, M., Loukas, A., Jones, M. K. and McManus, D. P. (2006) Identification of membrane-bound and secreted proteins from Echinococcus granulosus by signal sequence trap. International Journal for Parasitology, 36(1), pp. 123-130. (doi: 10.1016/j.ijpara.2005.09.001) (PMID:16229848)

2005

Pearson, M. S., McManus, D. P., Smyth, D. J. , Lewis, F. A. and Loukas, A. (2005) In vitro and in silico analysis of signal peptides from the human blood fluke, Schistosoma mansoni. FEMS Immunology and Medical Microbiology, 45(2), pp. 201-211. (doi: 10.1016/j.femsim.2005.03.009) (PMID:16051070)

2004

Laha, T., Loukas, A., Smyth, D. J. , Copeland, C. S. and Brindley, P. J. (2004) The fugitive LTR retrotransposon from the genome of the human blood fluke, Schistosoma mansoni. International Journal for Parasitology, 34(12), pp. 1365-1375. (doi: 10.1016/j.ijpara.2004.08.007) (PMID:15542097)

Don, T. A., Jones, M. K., Smyth, D. , O'Donoghue, P., Hotez, P. and Loukas, A. (2004) A pore-forming haemolysin from the hookworm, Ancylostoma caninum. International Journal for Parasitology, 34(9), pp. 1029-1035. (doi: 10.1016/j.ijpara.2004.04.013) (PMID:15313129)

2003

Xue, G.P., Patel, M., Johnson, J.S., Smyth, D.J. and Vickers, C.E. (2003) Selectable marker-free transgenic barley producing a high level of cellulase (1,4-β-glucanase) in developing grains. Plant Cell Reports, 21(11), pp. 1088-1094. (doi: 10.1007/s00299-003-0627-4) (PMID:12836003)

Smyth, D. , McManus, D. P., Smout, M. J., Laha, T., Zhang, W. and Loukas, A. (2003) Isolation of cDNAs encoding secreted and transmembrane proteins from Schistosoma mansoni by a signal sequence trap method. Infection and Immunity, 71(5), pp. 2548-2554. (doi: 10.1128/IAI.71.5.2548-2554.2003) (PMID:12704127) (PMCID:PMC153254)

2001

McManus, D. P., Wong, J. Y.M., Zhou, J., Cai, C., Zeng, Q., Smyth, D. , Li, Y., Kalinna, B. H., Duke, M. J. and Yi, X. (2001) Recombinant paramyosin (rec-Sj-97) tested for immunogenicity and vaccine efficacy against Schistosoma japonicum in mice and water buffaloes. Vaccine, 20(5-6), pp. 870-878. (doi: 10.1016/S0264-410X(01)00405-4) (PMID:11738752)

Brindley, P. J. et al. (2001) Proteolysis of human hemoglobin by schistosome cathepsin D. Molecular and Biochemical Parasitology, 112(1), pp. 103-112. (doi: 10.1016/S0166-6851(00)00351-0) (PMID:11166391)