Browse by Glasgow Author

2025

Campillo Poveda, M. et al. (2025) Metabolomic and functional analyses of small molecules secreted by intestinal nematodes in the activation of epithelial tuft cells. Metabolomics, 21(3), 55. (doi: 10.1007/s11306-025-02248-w) (PMID:40257648) (PMCID:PMC12011944)

Haines, L. R. et al. (2025) Anopheles mosquito survival and pharmacokinetic modeling show the mosquitocidal activity of nitisinone. Science Translational Medicine, 17(791), eadr4827. (doi: 10.1126/scitranslmed.adr4827) (PMID:40138457)

Richards, S. et al. (2025) Longitudinal observational (single cohort) study on the causes of trypanocide failure in cases of african animal trypanosomosis in cattle near wildlife protected areas of Northern Tanzania. PLoS Neglected Tropical Diseases, 19(1), e0012541. (doi: 10.1371/journal.pntd.0012541) (PMID:39836697) (PMCID:PMC11785308)

2024

Morrison, Liam J., Barrett, Michael P. ORCID: https://orcid.org/0000-0001-9447-3519, Steketee, Pieter C., Cecchi, Giuliano, Kijanga, Oliver, Mramba, Furaha and Auty, Harriet K. ORCID: https://orcid.org/0000-0002-6181-3780 (2024) What is needed to achieve effective and sustainable control of African animal trypanosomosis? Trends in Parasitology, 40(8), pp. 679-686. (doi: 10.1016/j.pt.2024.06.013) (PMID:39048503)

Griffin, Daniel, Despommier, Dickson, Naula, Christina ORCID: https://orcid.org/0000-0003-1165-693X and Barrett, Michael ORCID: https://orcid.org/0000-0001-9447-3519 (2024) This Week in Parasitism - TWiP 238: Eliminating sleeping sickness. [Audio]

Varghese, S. et al. (2024) Novel aroyl guanidine anti-trypanosomal compounds that exert opposing effects on parasite energy metabolism. European Journal of Medicinal Chemistry, 268, 116162. (doi: 10.1016/j.ejmech.2024.116162) (PMID:38394930)

Kovářová, Julie, Moos, Martin, Barrett, Michael P. ORCID: https://orcid.org/0000-0001-9447-3519, Horn, David and Zíková, Alena (2024) The bloodstream form of Trypanosoma brucei displays non-canonical gluconeogenesis. PLoS Neglected Tropical Diseases, 18(2), e0012007. (doi: 10.1371/journal.pntd.0012007) (PMID:38394337) (PMCID:PMC10917290)

2023

Simwela, N. V. et al. (2023) A conserved metabolic signature associated with response to fast-acting anti-malarial agents. Microbiology Spectrum, 11(6), e0397622. (doi: 10.1128/spectrum.03976-22) (PMID:37800971) (PMCID:PMC10714989)

Năstase, A.-M. et al. (2023) Alignment of multiple metabolomics LC-MS datasets from disparate diseases to reveal fever-associated metabolites. PLoS Neglected Tropical Diseases, 17(7), e0011133. (doi: 10.1371/journal.pntd.0011133) (PMID:37486920) (PMCID:PMC10399774)

Rao, S. P. S. et al. (2023) Cyanotriazoles are selective topoisomerase II poisons that rapidly cure trypanosome infections. Science, 380(6652), pp. 1349-1356. (doi: 10.1126/science.adh0614) (PMID:37384702)

Hu, Chunxiao ORCID: https://orcid.org/0000-0003-4031-1340, Annese, Valerio F. ORCID: https://orcid.org/0000-0002-7061-2032, Barrett, Michael P. ORCID: https://orcid.org/0000-0001-9447-3519 and Cumming, David R.S. ORCID: https://orcid.org/0000-0002-7838-8362 (2023) Point-of-care platform for diagnosis of venous thrombosis by simultaneous detection of thrombin generation and D-dimer in human plasma. Analytical Chemistry, 95(2), pp. 1115-1122. (doi: 10.1021/acs.analchem.2c03819) (PMID:36544272) (PMCID:PMC9850404)

2022

Hu, Chunxiao ORCID: https://orcid.org/0000-0003-4031-1340, Annese, Valerio F. ORCID: https://orcid.org/0000-0002-7061-2032, Giagkoulovits, Christos ORCID: https://orcid.org/0000-0002-5447-4311, Barrett, Michael P. ORCID: https://orcid.org/0000-0001-9447-3519 and Cumming, David R. S. ORCID: https://orcid.org/0000-0002-7838-8362 (2022) Factor VIII companion diagnostic for haemophilia. Frontiers in Bioengineering and Biotechnology, 10, 1006600. (doi: 10.3389/fbioe.2022.1006600) (PMID:36277382) (PMCID:PMC9579283)

Annese, Valerio F. ORCID: https://orcid.org/0000-0002-7061-2032, Hu, Chunxiao ORCID: https://orcid.org/0000-0003-4031-1340, Barrett, Michael P. ORCID: https://orcid.org/0000-0001-9447-3519, Jones, Rob ORCID: https://orcid.org/0000-0002-2904-6980 and Cumming, David R. S. ORCID: https://orcid.org/0000-0002-7838-8362 (2022) A CMOS-based multi-omics detection platform for simultaneous quantification of proteolytically active prostate specific antigen and glutamate in urine. IEEE Sensors Journal, 22(19), pp. 18870-18877. (doi: 10.1109/JSEN.2022.3198282)

Alpizar-Sosa, Edubiel A., Kumordzi, Yasmine, Wei, Wenbin, Whitfield, Phillip D. ORCID: https://orcid.org/0000-0002-0814-4119, Barrett, Michael P. ORCID: https://orcid.org/0000-0001-9447-3519 and Denny, Paul W. (2022) Genome deletions to overcome the directed loss of gene function in Leishmania. Frontiers in Cellular and Infection Microbiology, 12, 988688. (doi: 10.3389/fcimb.2022.988688) (PMID:36211960) (PMCID:PMC9539739)

Koester, D. C. et al. (2022) Discovery of novel quinoline-based proteasome inhibitors for human African trypanosomiasis (HAT). Journal of Medicinal Chemistry, 65(17), pp. 11776-11787. (doi: 10.1021/acs.jmedchem.2c00791) (PMID:35993839) (PMCID:PMC9469205)

Alpizar-Sosa, E. A. et al. (2022) Amphotericin B resistance in Leishmania mexicana: Alterations to sterol metabolism and oxidative stress response. PLoS Neglected Tropical Diseases, 16(9), e0010779. (doi: 10.1371/journal.pntd.0010779) (PMID:36170238) (PMCID:PMC9581426)

Sanchez, Cecilia P., Manson, Erin D. T., Moliner Cubel, Sonia, Mandel, Luis, Weidt, Stefan K., Barrett, Michael P. ORCID: https://orcid.org/0000-0001-9447-3519 and Lanzer, Michael (2022) The knock-down of the chloroquine resistance transporter PfCRT is linked to oligopeptide handling in Plasmodium falciparum. Microbiology Spectrum, 10(4), e0110122. (doi: 10.1128/spectrum.01101-22) (PMID:35867395) (PMCID:PMC9431119)

Jara, Marlene, Barrett, Michael ORCID: https://orcid.org/0000-0001-9447-3519, Maes, Ilse, Regnault, Clement, Imamura, Hideo, Domagalska, Malgorzata Anna and Dujardin, Jean-Claude (2022) Transcriptional shift and metabolic adaptations during Leishmania quiescence using stationary phase and drug pressure as models. Microorganisms, 10(1), 97. (doi: 10.3390/microorganisms10010097) (PMID:35056546) (PMCID:PMC8781126)

2021

Steketee, Pieter C., Giordani, Federica ORCID: https://orcid.org/0000-0001-9964-281X, Vincent, Isabel M. ORCID: https://orcid.org/0000-0003-2663-4389, Crouch, Kathryn ORCID: https://orcid.org/0000-0001-9310-4762, Achcar, Fiona ORCID: https://orcid.org/0000-0001-8792-7615, Dickens, Nicholas J. ORCID: https://orcid.org/0000-0003-0492-5855, Morrison, Liam J., MacLeod, Annette ORCID: https://orcid.org/0000-0002-0150-5049 and Barrett, Michael P. ORCID: https://orcid.org/0000-0001-9447-3519 (2021) Transcriptional differentiation of Trypanosoma brucei during in vitro acquisition of resistance to acoziborole. PLoS Neglected Tropical Diseases, 15(11), e0009939. (doi: 10.1371/journal.pntd.0009939) (PMID:34752454) (PMCID:PMC8648117)

Richards, Shauna, Morrison, Liam J., Torr, Steve J., Barrett, Michael P. ORCID: https://orcid.org/0000-0001-9447-3519, Manangwa, Oliver, Mramba, Furaha and Auty, Harriet ORCID: https://orcid.org/0000-0002-6181-3780 (2021) Pharma to farmer: field challenges of optimizing trypanocide use in African animal trypanosomiasis. Trends in Parasitology, 37(9), pp. 831-843. (doi: 10.1016/j.pt.2021.04.007) (PMID:33962879)

Brooke, D. P. et al. (2021) Truncated S-MGBs: towards a parasite-specific and low aggregation chemotype. RSC Medicinal Chemistry, 12(8), pp. 1391-1401. (doi: 10.1039/D1MD00110H)

Carruthers, L. V. et al. (2021) Diminazene resistance in Trypanosoma congolense is not caused by reduced transport capacity but associated with reduced mitochondrial membrane potential. Molecular Microbiology, 116(2), pp. 564-588. (doi: 10.1111/mmi.14733) (PMID:33932053)

Steketee, P. C. et al. (2021) Divergent metabolism between Trypanosoma congolense and Trypanosoma brucei results in differential sensitivity to metabolic inhibition. PLoS Pathogens, 17(7), e1009734. (doi: 10.1371/journal.ppat.1009734) (PMID:34310651) (PMCID:PMC8384185)

Biddau, M. et al. (2021) Plasmodium falciparum LipB mutants display altered redox and carbon metabolism in asexual stages and cannot complete sporogony in Anopheles mosquitoes. International Journal for Parasitology, 51(6), pp. 441-453. (doi: 10.1016/j.ijpara.2020.10.011) (PMID:33713652) (PMCID:PMC8126644)

Annese, V. F. et al. (2021) A monolithic single-chip point-of-care platform for metabolomic prostate cancer detection. Microsystems and Nanoengineering, 7, 21. (doi: 10.1038/s41378-021-00243-4) (PMID:34567735) (PMCID:PMC8433377)

Milne, K. et al. (2021) Mapping immune variation and var gene switching in naive hosts infected with Plasmodium falciparum. eLife, 10, e62800. (doi: 10.7554/elife.62800) (PMID:33648633) (PMCID:PMC7924948)

Villafraz, O. et al. (2021) Procyclic trypanosomes recycle glucose catabolites and TCA cycle intermediates to stimulate growth in the presence of physiological amounts of proline. PLoS Pathogens, 17(3), e1009204. (doi: 10.1371/journal.ppat.1009204) (PMID:33647053) (PMCID:PMC7951978)

Simwela, Nelson, Hughes, Katie R., Rennie, Michael T., Barrett, Michael P. ORCID: https://orcid.org/0000-0001-9447-3519 and Waters, Andrew P. ORCID: https://orcid.org/0000-0001-8900-2982 (2021) Mammalian deubiquitinating enzyme inhibitors display. ACS Infectious Diseases, 7(2), pp. 333-346. (doi: 10.1021/acsinfecdis.0c00580) (PMID:33400499)

Mina, J. G.M. et al. (2021) Antileishmanial chemotherapy through clemastine fumarate mediated inhibition of the Leishmania inositol phosphorylceramide synthase. ACS Infectious Diseases, 7(1), pp. 47-63. (doi: 10.1021/acsinfecdis.0c00546) (PMID:33291887) (PMCID:PMC7802075)

2020

Cockram, Peter E., Dickie, Emily A., Barrett, Michael P. ORCID: https://orcid.org/0000-0001-9447-3519 and Smith, Terry K. (2020) Halogenated tryptophan derivatives disrupt essential transamination mechanisms in bloodstream form Trypanosoma brucei. PLoS Neglected Tropical Diseases, 14(12), e0008928. (doi: 10.1371/journal.pntd.0008928) (PMID:33275612) (PMCID:PMC7744056)

Giordani, F. et al. (2020) Veterinary trypanocidal benzoxaboroles are peptidase-activated prodrugs. PLoS Pathogens, 16(11), e1008932. (doi: 10.1371/journal.ppat.1008932) (PMID:33141865) (PMCID:PMC7710103)

Blackburn, G. et al. (2020) Running on empty: a metabolomics approach to investigating changing energy metabolism during fasted exercise and rest. Metabolites, 10(10), 399. (doi: 10.3390/metabo10100399) (PMID:33050077) (PMCID:PMC7600507)

Saldivia, M. et al. (2020) Targeting the trypanosome kinetochore with CLK1 protein kinase inhibitors. Nature Microbiology, 5(10), pp. 1207-1216. (doi: 10.1038/s41564-020-0745-6) (PMID:32661312) (PMCID:PMC7610364)

Hu, Chunxiao ORCID: https://orcid.org/0000-0003-4031-1340, Annese, Valerio ORCID: https://orcid.org/0000-0002-7061-2032, Velugotla, Srinivas ORCID: https://orcid.org/0000-0002-9231-2495, Al-Rawhani, Mohammed A., Cheah, Boon Chong ORCID: https://orcid.org/0000-0002-2580-4094, Grant, James ORCID: https://orcid.org/0000-0003-3562-393X, Barrett, Michael P. ORCID: https://orcid.org/0000-0001-9447-3519 and Cumming, David R.S. ORCID: https://orcid.org/0000-0002-7838-8362 (2020) Disposable paper-on-CMOS platform for real-time simultaneous detection of metabolites. IEEE Transactions on Biomedical Engineering, 67(9), pp. 2417-2426. (doi: 10.1109/TBME.2019.2962239)

Daly, R. et al. (2020) Changes in plasma itaconate elevation in early rheumatoid arthritis patients elucidates disease activity associated macrophage activation. Metabolites, 10(6), 241. (doi: 10.3390/metabo10060241) (PMID:32531990) (PMCID:PMC7344783)

Doleželová, Eva, Kunzová, Michaela, Dejung, Mario, Levin, Michal, Panicucci, Brian, Regnault, Clément, Janzen, Christian J., Barrett, Michael P. ORCID: https://orcid.org/0000-0001-9447-3519, Butter, Falk and Zíková, Alena (2020) Cell-based and multi-omics profiling reveals dynamic metabolic repurposing of mitochondria to drive developmental progression of Trypanosoma brucei. PLoS Biology, 18(6), e3000741. (doi: 10.1371/journal.pbio.3000741) (PMID:32520929) (PMCID:PMC7307792)

Simwela, Nelson, Hughes, Katie R., Roberts, A. Brett, Rennie, Michael T., Barrett, Michael P. ORCID: https://orcid.org/0000-0001-9447-3519 and Waters, Andrew P. ORCID: https://orcid.org/0000-0001-8900-2982 (2020) Experimentally engineered mutations in a ubiquitin hydrolase, UBP-1, modulate in vivo susceptibility to artemisinin and chloroquine in Plasmodium berghei. Antimicrobial Agents and Chemotherapy, 64(7), (doi: 10.1128/AAC.02484-19) (PMID:32340987) (PMCID:PMC7318008)

Zoltner, M. et al. (2020) Suramin exposure alters cellular metabolism and mitochondrial energy production in African trypanosomes. Journal of Biological Chemistry, 295(24), pp. 8331-8347. (doi: 10.1074/jbc.ra120.012355) (PMID:32354742) (PMCID:PMC7294092)

Rodgers, Lewis C., Cole, John, Rattigan, Kevin M., Barrett, Michael P. ORCID: https://orcid.org/0000-0001-9447-3519, Kurian, Nisha, McInnes, Iain B. ORCID: https://orcid.org/0000-0002-6462-4280 and Goodyear, Carl S. ORCID: https://orcid.org/0000-0001-5926-5941 (2020) The rheumatoid synovial environment alters fatty acid metabolism in human monocytes and enhances CCL20 secretion. Rheumatology, 59(4), pp. 869-878. (doi: 10.1093/rheumatology/kez378) (PMID:31497857)

Rao, S. P.S. et al. (2020) Anti-Trypanosomal proteasome inhibitors cure hemolymphatic and meningoencephalic murine infection models of African Trypanosomiasis. Tropical Medicine and Infectious Disease, 5(1), 28. (doi: 10.3390/tropicalmed5010028) (PMID:32079320) (PMCID:PMC7157554)

Ritchie, Ryan, Barrett, Michael P. ORCID: https://orcid.org/0000-0001-9447-3519, Mottram, Jeremy C. ORCID: https://orcid.org/0000-0001-5574-3766 and Myburgh, Elmarie ORCID: https://orcid.org/0000-0002-2007-5902 (2020) In vivo bioluminescence imaging to assess compound efficacy against Trypanosoma brucei. In: Michels, Paul A.M., Ginger, Michael L. and Zilberstein, Dan (eds.) Trypanosomatids: Methods and Protocols. Series: Methods in molecular biology (2116). Humana Press: New York, NY, pp. 801-817. ISBN 9781071602935 (doi: 10.1007/978-1-0716-0294-2_48)

Dickie, Emily A., Giordani, Federica ORCID: https://orcid.org/0000-0001-9964-281X, Gould, Matthew K., Maeser, Pascal, Burri, Christian, Mottram, Jeremy C. ORCID: https://orcid.org/0000-0001-5574-3766, Rao, Srinivasa P.S. and Barrett, Michael P. ORCID: https://orcid.org/0000-0001-9447-3519 (2020) New drugs for human African trypanosomiasis:a twenty first century success story. Tropical Medicine and Infectious Disease, 5(1), 29. (doi: 10.3390/tropicalmed5010029) (PMID:32092897) (PMCID:PMC7157223)

Al-Rawhani, M. A. et al. (2020) Multimodal integrated sensor platform for rapid biomarker detection. IEEE Transactions on Biomedical Engineering, 67(2), pp. 614-623. (doi: 10.1109/TBME.2019.2919192) (PMID:31226063)

Lindner, A. K. et al. (2020) New WHO guidelines for treatment of gambiense human African trypanosomiasis including fexinidazole: substantial changes for clinical practice. Lancet Infectious Diseases, 20(2), e38-e46. (doi: 10.1016/S1473-3099(19)30612-7) (PMID:31879061)

2019

Lim, Andrew S. T., Vincent, Isabel M. ORCID: https://orcid.org/0000-0003-2663-4389, Barrett, Michael P. ORCID: https://orcid.org/0000-0001-9447-3519 and Gilbert, Ian H. (2019) Small polar hits against S. aureus: screening, initial hit optimization, and metabolomic studies. ACS Omega, 4(21), pp. 19199-19215. (doi: 10.1021/acsomega.9b02507) (PMID:31763544) (PMCID:PMC6869403)

Pountain, Andrew W. ORCID: https://orcid.org/0000-0001-9651-5145 and Barrett, Michael P. ORCID: https://orcid.org/0000-0001-9447-3519 (2019) Untargeted metabolomics to understand the basis of phenotypic differences in amphotericin B-resistant. Wellcome Open Research, 4, 176. (doi: 10.12688/wellcomeopenres.15452.1) (PMID:32133420) (PMCID:PMC7041363)

Johnston, Katharina, Kim, Dong-Hyun, Kerkhoven, Eduard J., Burchmore, Richard ORCID: https://orcid.org/0000-0003-1663-9004, Barrett, Michael P. ORCID: https://orcid.org/0000-0001-9447-3519 and Achcar, Fiona ORCID: https://orcid.org/0000-0001-8792-7615 (2019) Mapping the metabolism of five amino acids in bloodstream form Trypanosoma brucei using U-13C-labelled substrates and LC-MS. Bioscience Reports, 39(5), BSR2018160. (doi: 10.1042/BSR20181601) (PMID:31028136) (PMCID:PMC6522824)

Giordani, Federica ORCID: https://orcid.org/0000-0001-9964-281X, Khalaf, Abedawn I., Gillingwater, Kirsten, Munday, Jane C. ORCID: https://orcid.org/0000-0001-7792-2749, de Koning, Harry P. ORCID: https://orcid.org/0000-0002-9963-1827, Suckling, Colin J., Barrett, Michael P. ORCID: https://orcid.org/0000-0001-9447-3519 and Scott, Fraser J. (2019) Novel minor groove binders cure animal African trypanosomiasis in an in vivo mouse model. Journal of Medicinal Chemistry, 62(6), pp. 3021-3035. (doi: 10.1021/acs.jmedchem.8b01847) (PMID:30763102)

Rao, S. P.S. et al. (2019) Drug discovery for kinetoplastid diseases: future directions. ACS Infectious Diseases, 5(2), pp. 152-157. (doi: 10.1021/acsinfecdis.8b00298) (PMID:30543391)

Pountain, Andrew W. ORCID: https://orcid.org/0000-0001-9651-5145, Weidt, Stefan K., Regnault, Clément, Bates, Paul A., Donachie, Anne M., Dickens, Nicholas J. ORCID: https://orcid.org/0000-0003-0492-5855 and Barrett, Michael P. ORCID: https://orcid.org/0000-0001-9447-3519 (2019) Genomic instability at the locus of sterol C24-methyltransferase promotes amphotericin B resistance in Leishmania parasites. PLoS Neglected Tropical Diseases, 13(2), e0007052. (doi: 10.1371/journal.pntd.0007052) (PMID:30716073) (PMCID:PMC6375703)

2018

Patil, Samadhan B., Dheeman, Dharmendra S., Al-Rawhani, Mohammed A., Velugotla, Srinivas ORCID: https://orcid.org/0000-0002-9231-2495, Nagy, Bence, Cheah, Boon Chong ORCID: https://orcid.org/0000-0002-2580-4094, Grant, James P. ORCID: https://orcid.org/0000-0003-3562-393X, Accarino, Claudio, Barrett, Michael P. ORCID: https://orcid.org/0000-0001-9447-3519 and Cumming, David R.S. ORCID: https://orcid.org/0000-0002-7838-8362 (2018) An integrated portable system for single chip simultaneous measurement of multiple disease associated metabolites. Biosensors and Bioelectronics, 122, pp. 88-94. (doi: 10.1016/j.bios.2018.09.013) (PMID:30245326)

Diaz-Albiter, Hector M., Regnault, Clément, Alpizar-Sosa, Edubiel A., McGuinness, Dagmara ORCID: https://orcid.org/0000-0001-9057-3504, Barrett, Michael P. ORCID: https://orcid.org/0000-0001-9447-3519 and Dillon, Rod J. (2018) Non-invasive visualisation and identification of fluorescent. Wellcome Open Research, 3, 160. (doi: 10.12688/wellcomeopenres.14910.1) (PMID:30756095) (PMCID:PMC6367660)

Barrett, Michael P. ORCID: https://orcid.org/0000-0001-9447-3519 (2018) The elimination of human African trypanosomiasis is in sight: report from the third WHO stakeholders meeting on elimination of gambiense human African trypanosomiasis. PLoS Neglected Tropical Diseases, 12(12), e0006925. (doi: 10.1371/journal.pntd.0006925) (PMID:30521522) (PMCID:PMC6283460)

Kovářová, Julie, Nagar, Rupa, Faria, Joana, Ferguson, Michael A.J., Barrett, Michael P. ORCID: https://orcid.org/0000-0001-9447-3519 and Horn, David (2018) Gluconeogenesis using glycerol as a substrate in bloodstream-form Trypanosoma brucei. PLoS Pathogens, 14(12), e1007475. (doi: 10.1371/journal.ppat.1007475) (PMID:30589893) (PMCID:PMC6307712)

Begolo, D. et al. (2018) The trypanocidal benzoxaborole AN7973 inhibits trypanosome mRNA processing. PLoS Pathogens, 14(9), e1007315. (doi: 10.1371/journal.ppat.1007315) (PMID:30252911) (PMCID:PMC6173450)

Newton, James, Ramage, Gordon ORCID: https://orcid.org/0000-0002-0932-3514, Gadegaard, Nikolaj ORCID: https://orcid.org/0000-0002-3396-846X, Zachs, William, Rogers, Simon ORCID: https://orcid.org/0000-0003-3578-4477, Barrett, Michael P. ORCID: https://orcid.org/0000-0001-9447-3519, Carruthers, Gerard ORCID: https://orcid.org/0000-0002-7188-9797 and Burgess, Karl (2018) Minimally-destructive atmospheric ionisation mass spectrometry authenticates authorship of historical manuscripts. Scientific Reports, 8, 10944. (doi: 10.1038/s41598-018-28810-2) (PMID:30050048) (PMCID:PMC6062563)

Steketee, P. C. et al. (2018) Benzoxaborole treatment perturbs S-adenosyl-L-methionine metabolism in Trypanosoma brucei. PLoS Neglected Tropical Diseases, 12(5), e0006450. (doi: 10.1371/journal.pntd.0006450) (PMID:29758036) (PMCID:PMC5976210)

Armitage, E. G. et al. (2018) Complex interplay between sphingolipid and sterol metabolism revealed by perturbations to the Leishmania metabolome caused by miltefosine. Antimicrobial Agents and Chemotherapy, 62(5), e02095-17. (doi: 10.1128/AAC.02095-17) (PMID:29463533)

Armitage, E. G. et al. (2018) Metabolic clustering analysis as a strategy for compound selection in the drug discovery pipeline for leishmaniasis. ACS Chemical Biology, 13(5), pp. 1361-1369. (doi: 10.1021/acschembio.8b00204) (PMID:29671577)

Nagy, Bence, Al-Rawhani, Mohammed A., Cheah, Boon Chong, Barrett, Michael P. ORCID: https://orcid.org/0000-0001-9447-3519 and Cumming, David R.S. ORCID: https://orcid.org/0000-0002-7838-8362 (2018) Immunoassay multiplexing on a complementary metal oxide semiconductor photodiode array. ACS Sensors, 3(5), pp. 953-959. (doi: 10.1021/acssensors.7b00972) (PMID:29652490) (PMCID:PMC5974700)

Kovarova, Julie, Pountain, Andrew W. ORCID: https://orcid.org/0000-0001-9651-5145, Wildridge, David, Weidt, Stefan, Bringaud, Frédéric, Burchmore, Richard J.S. ORCID: https://orcid.org/0000-0003-1663-9004, Achcar, Fiona ORCID: https://orcid.org/0000-0001-8792-7615 and Barrett, Michael P. ORCID: https://orcid.org/0000-0001-9447-3519 (2018) Deletion of transketolase triggers a stringent metabolic response in promastigotes and loss of virulence in amastigotes of Leishmania mexicana. PLoS Pathogens, 14(3), e1006953. (doi: 10.1371/journal.ppat.1006953) (PMID:29554142) (PMCID:PMC5882173)

Rattigan, Kevin M., Pountain, Andrew W. ORCID: https://orcid.org/0000-0001-9651-5145, Regnault, Clement, Achcar, Fiona ORCID: https://orcid.org/0000-0001-8792-7615, Vincent, Isabel M. ORCID: https://orcid.org/0000-0003-2663-4389, Goodyear, Carl S. ORCID: https://orcid.org/0000-0001-5926-5941 and Barrett, Michael P. ORCID: https://orcid.org/0000-0001-9447-3519 (2018) Metabolomic profiling of macrophages determines the discrete metabolomic signature and metabolomic interactome triggered by polarising immune stimuli. PLoS ONE, 13(3), e0194126. (doi: 10.1371/journal.pone.0194126) (PMID:29538444) (PMCID:PMC5851634)

Zhang, N. et al. (2018) Host-parasite co-metabolic activation of antitrypanosomal aminomethyl-benzoxaboroles. PLoS Pathogens, 14(2), e1006850. (doi: 10.1371/journal.ppat.1006850) (PMID:29425238) (PMCID:PMC5823473)

Nayak, Archana, Akpunarlieva, Snezhana, Barrett, Michael ORCID: https://orcid.org/0000-0001-9447-3519 and Burchmore, Richard ORCID: https://orcid.org/0000-0003-1663-9004 (2018) A defined medium for Leishmania culture allows definition of essential amino acids. Experimental Parasitology, 185, pp. 39-52. (doi: 10.1016/j.exppara.2018.01.009) (PMID:29326050)

Wandy, Joe ORCID: https://orcid.org/0000-0002-3068-4664, Zhu, Yunfeng, van der Hooft, Justin J.J. ORCID: https://orcid.org/0000-0002-9340-5511, Daly, Rónán ORCID: https://orcid.org/0000-0002-1275-6820, Barrett, Michael P. ORCID: https://orcid.org/0000-0001-9447-3519 and Rogers, Simon ORCID: https://orcid.org/0000-0003-3578-4477 (2018) Ms2lda.org: web-based topic modelling for substructure discovery in mass spectrometry. Bioinformatics, 34(2), pp. 317-318. (doi: 10.1093/bioinformatics/btx582) (PMID:28968802) (PMCID:PMC5860206)

2017

Gloaguen, Yoann ORCID: https://orcid.org/0000-0003-0493-8592, Morton, Fraser ORCID: https://orcid.org/0000-0001-5328-9467, Daly, Rónán ORCID: https://orcid.org/0000-0002-1275-6820, Gurden, Ross, Rogers, Simon ORCID: https://orcid.org/0000-0003-3578-4477, Wandy, Joe ORCID: https://orcid.org/0000-0002-3068-4664, Wilson, David, Barrett, Michael ORCID: https://orcid.org/0000-0001-9447-3519 and Burgess, Karl (2017) PiMP my metabolome: An integrated, web-based tool for LC-MS metabolomics data. Bioinformatics, 33(24), pp. 4007-4009. (doi: 10.1093/bioinformatics/btx499) (PMID:28961954) (PMCID:PMC5860087)

Ponte-Sucre, Alicia, Gamarro, Francisco, Dujardin, Jean-Claude, Barrett, Michael P. ORCID: https://orcid.org/0000-0001-9447-3519, López-Vélez, Rogelio, García-Hernández, Raquel, Pountain, Andrew W. ORCID: https://orcid.org/0000-0001-9651-5145 and Mwenechanya, Roy (2017) Drug resistance and treatment failure in leishmaniasis: A 21st century challenge. PLoS Neglected Tropical Diseases, 11(12), e0006052. (doi: 10.1371/journal.pntd.0006052) (PMID:29240765) (PMCID:PMC5730103)

Barrett, Michael P. ORCID: https://orcid.org/0000-0001-9447-3519, Cooper, Jonathan M. ORCID: https://orcid.org/0000-0002-2358-1050, Regnault, Clément, Holm, Stefan H., Beech, Jason P., Tegenfeldt, Jonas O. and Hochstetter, Axel ORCID: https://orcid.org/0000-0002-2791-2400 (2017) Microfluidics-based approaches to the isolation of African trypanosomes. Pathogens, 6(4), 47. (doi: 10.3390/pathogens6040047) (PMID:28981471) (PMCID:PMC5750571)

Barrett, Michael P. ORCID: https://orcid.org/0000-0001-9447-3519 and Giordani, Federica ORCID: https://orcid.org/0000-0001-9964-281X (2017) Inside Doctor Livingstone: a Scottish icon's encounter with tropical disease. Parasitology, 144(12), pp. 1652-1662. (doi: 10.1017/S003118201600202X) (PMID:27928980)

Scott, F. J. et al. (2017) An evaluation of Minor Groove Binders as anti-fungal and anti-mycobacterial therapeutics. European Journal of Medicinal Chemistry, 136, pp. 561-572. (doi: 10.1016/j.ejmech.2017.05.039)

Alzahrani, Khalid J.H., Ali, Juma A.M., Eze, Anthonius A., Looi, Wan Limm, Tagoe, Daniel N.A., Creek, Darren J., Barrett, Michael P. ORCID: https://orcid.org/0000-0001-9447-3519 and De Koning, Harry P. ORCID: https://orcid.org/0000-0002-9963-1827 (2017) Functional and genetic evidence that nucleoside transport is highly conserved in Leishmania species: Implications for pyrimidine-based chemotherapy. International Journal for Parasitology: Drugs and Drug Resistance, 7(2), pp. 206-226. (doi: 10.1016/j.ijpddr.2017.04.003) (PMID:28453984) (PMCID:PMC5407577)

van der Hooft, Justin J.J. ORCID: https://orcid.org/0000-0002-9340-5511, Wandy, Joe ORCID: https://orcid.org/0000-0002-3068-4664, Young, Francesca, Padmanabhan, Sandosh ORCID: https://orcid.org/0000-0003-3869-5808, Gerasimidis, Konstantinos ORCID: https://orcid.org/0000-0001-9432-2200, Burgess, Karl E.V., Barrett, Michael P. ORCID: https://orcid.org/0000-0001-9447-3519 and Rogers, Simon ORCID: https://orcid.org/0000-0003-3578-4477 (2017) Unsupervised discovery and comparison of structural families across multiple samples in untargeted metabolomics. Analytical Chemistry, 89(14), pp. 7569-7577. (doi: 10.1021/acs.analchem.7b01391) (PMID:28621528) (PMCID:PMC5524435)

Akpunarlieva, Snezhana, Weidt, Stefan, Lamasudin, Dhilia, Naula, Christina ORCID: https://orcid.org/0000-0003-1165-693X, Henderson, David, Barrett, Michael ORCID: https://orcid.org/0000-0001-9447-3519, Burgess, Karl and Burchmore, Richard ORCID: https://orcid.org/0000-0003-1663-9004 (2017) Integration of proteomics and metabolomics to elucidate metabolic adaptation in Leishmania. Journal of Proteomics, 155, pp. 85-98. (doi: 10.1016/j.jprot.2016.12.009) (PMID:28040509)

Al-Rawhani, M. A. et al. (2017) A colorimetric CMOS-based platform for rapid total serum cholesterol quantification. IEEE Sensors Journal, 17(2), pp. 240-247. (doi: 10.1109/JSEN.2016.2629018)

Cheah, Boon Chong ORCID: https://orcid.org/0000-0002-2580-4094, MacDonald, Alasdair I., Barrett, Michael P. ORCID: https://orcid.org/0000-0001-9447-3519 and Cumming, David R.S. ORCID: https://orcid.org/0000-0002-7838-8362 (2017) Metabolomics on integrated circuit. Procedia Technology, 27, pp. 53-54. (doi: 10.1016/j.protcy.2017.04.025)

2016

Srivastava, Anubhav, Philip, Nisha, Hughes, Katie R., Georgiou, Konstantina, MacRae, James I., Barrett, Michael P. ORCID: https://orcid.org/0000-0001-9447-3519, Creek, Darren J., McConville, Malcolm J. and Waters, Andrew P. ORCID: https://orcid.org/0000-0001-8900-2982 (2016) Stage-specific changes in plasmodium metabolism required for differentiation and adaptation to different host and vector environments. PLoS Pathogens, 12(12), e1006094. (doi: 10.1371/journal.ppat.1006094) (PMID:28027318) (PMCID:PMC5189940)

Vincent, Isabel M. ORCID: https://orcid.org/0000-0003-2663-4389, Daly, Rónán ORCID: https://orcid.org/0000-0002-1275-6820, Courtioux, Bertrand, Cattanach, Amy M., Biéler, Sylvain, Ndung’u, Joseph M., Bisser, Sylvie and Barrett, Michael P. ORCID: https://orcid.org/0000-0001-9447-3519 (2016) Metabolomics Identifies multiple candidate biomarkers to diagnose and stage human African trypanosomiasis. PLoS Neglected Tropical Diseases, 10(12), e0005140. (doi: 10.1371/journal.pntd.0005140) (PMID:27941966) (PMCID:PMC5152828)

Biéler, S. et al. (2016) Evaluation of antigens for development of a serological test for human African trypanosomiasis. PLoS ONE, 11(12), e0168074. (doi: 10.1371/journal.pone.0168074) (PMID:27936225) (PMCID:PMC5148118)

Giordani, Federica ORCID: https://orcid.org/0000-0001-9964-281X, Morrison, Liam J., Rowan, Tim G., De Koning, Harry P. ORCID: https://orcid.org/0000-0002-9963-1827 and Barrett, Michael P. ORCID: https://orcid.org/0000-0001-9447-3519 (2016) The animal trypanosomiases and their chemotherapy: a review. Parasitology, 143(14), pp. 1862-1889. (doi: 10.1017/S0031182016001268) (PMID:27719692) (PMCID:PMC5142301)

van Der Hooft, Justin Johan Jozias ORCID: https://orcid.org/0000-0002-9340-5511, Wandy, Joe ORCID: https://orcid.org/0000-0002-3068-4664, Barrett, Michael P. ORCID: https://orcid.org/0000-0001-9447-3519, Burgess, Karl E.V. and Rogers, Simon ORCID: https://orcid.org/0000-0003-3578-4477 (2016) Topic modeling for untargeted substructure exploration in metabolomics. Proceedings of the National Academy of Sciences of the United States of America, 113(48), pp. 13738-13743. (doi: 10.1073/pnas.1608041113) (PMID:27856765) (PMCID:PMC5137707)

Van Der Hooft, Justin ORCID: https://orcid.org/0000-0002-9340-5511, Padmanabhan, Sandosh ORCID: https://orcid.org/0000-0003-3869-5808, Burgess, Karl and Barrett, Michael ORCID: https://orcid.org/0000-0001-9447-3519 (2016) Erratum to: Urinary antihypertensive drug metabolite screening using molecular networking coupled to high-resolution mass spectrometry fragmentation. Metabolomics, 12(8), 139. (doi: 10.1007/s11306-016-1078-6)

Holm, S.H., Beech, J.P., Barrett, M.P. ORCID: https://orcid.org/0000-0001-9447-3519 and Tegenfeldt, J.O. (2016) Correction: simplifying microfluidic separation devices towards field-detection of blood parasites. Analytical Methods, 8(28), p. 5726. (doi: 10.1039/c6ay90099b)

Van Der Hooft, Justin J.J. ORCID: https://orcid.org/0000-0002-9340-5511, Padmanabhan, Sandosh ORCID: https://orcid.org/0000-0003-3869-5808, Burgess, Karl E.V. and Barrett, Michael P. ORCID: https://orcid.org/0000-0001-9447-3519 (2016) Urinary antihypertensive drug metabolite screening using molecular networking coupled to high-resolution mass spectrometry fragmentation. Metabolomics, 12, 125. (doi: 10.1007/s11306-016-1064-z) (PMID:27471437) (PMCID:PMC4932139)

Cheah, Boon Chong ORCID: https://orcid.org/0000-0002-2580-4094, MacDonald, Alasdair Iain, Martin, Christopher, Streklas, Angelos J., Campbell, Gordon, Al-Rawhani, Mohammed A., Nemeth, Balazs, Grant, James P. ORCID: https://orcid.org/0000-0003-3562-393X, Barrett, Michael P. ORCID: https://orcid.org/0000-0001-9447-3519 and Cumming, David R.S. ORCID: https://orcid.org/0000-0002-7838-8362 (2016) An integrated circuit for chip-based analysis of enzyme kinetics and metabolite quantification. IEEE Transactions on Biomedical Circuits and Systems, 10(3), pp. 721-730. (doi: 10.1109/TBCAS.2015.2487603) (PMID:26742138)

Scott, Fraser J., Khalaf, Abedawn I., Giordani, Federica ORCID: https://orcid.org/0000-0001-9964-281X, Wong, Pui Ee, Duffy, Sandra, Barrett, Michael ORCID: https://orcid.org/0000-0001-9447-3519, Avery, Vicky M. and Suckling, Colin J. (2016) An evaluation of Minor Groove Binders as anti-Trypanosoma brucei brucei therapeutics. European Journal of Medicinal Chemistry, 116, pp. 116-125. (doi: 10.1016/j.ejmech.2016.03.064) (PMID:27060763) (PMCID:PMC4872591)

Holm, S.H., Beech, J.P., Barrett, M.P. ORCID: https://orcid.org/0000-0001-9447-3519 and Tegenfeldt, J.O. (2016) Simplifying microfluidic separation devices towards field-detection of blood parasites. Analytical Methods, 8(16), pp. 3291-3300. (doi: 10.1039/c6ay00443a)

Vincent, Isabel M., Ehmann, David E., Mills, Scott D., Perros, Manos and Barrett, Michael P. ORCID: https://orcid.org/0000-0001-9447-3519 (2016) Untargeted metabolomics to ascertain antibiotic modes of action. Antimicrobial Agents and Chemotherapy, 60(4), pp. 2281-2291. (doi: 10.1128/AAC.02109-15) (PMID:26833150) (PMCID:PMC4808186)

Barrett, M. ORCID: https://orcid.org/0000-0001-9447-3519, Sloan, W. ORCID: https://orcid.org/0000-0002-9450-7384, Stark, W. ORCID: https://orcid.org/0000-0001-8086-2572 and Watson, I. ORCID: https://orcid.org/0000-0002-4002-4977 (2016) New Developments in Synthetic Biology at the University of Glasgow. Industrial Biotechnology Innovation Centre Annual Conference, Glasgow, UK, 28-29 Jan 2016.

2015

Kim, Dong-Hyun, Achcar, Fiona ORCID: https://orcid.org/0000-0001-8792-7615, Breitling, Rainer ORCID: https://orcid.org/0000-0001-7173-0922, Burgess, Karl E. and Barrett, Michael P. ORCID: https://orcid.org/0000-0001-9447-3519 (2015) LC–MS-based absolute metabolite quantification: application to metabolic flux measurement in trypanosomes. Metabolomics, 11(6), pp. 1721-1732. (doi: 10.1007/s11306-015-0827-2) (PMID:26491423) (PMCID:PMC4605981)

Baker, N., Hamilton, G., Wilkes, J.M. ORCID: https://orcid.org/0000-0002-0920-6967, Hutchinson, S., Barrett, M.P. ORCID: https://orcid.org/0000-0001-9447-3519 and Horn, D. (2015) Vacuolar ATPase depletion affects mitochondrial ATPase function, kinetoplast dependency, and drug sensitivity in trypanosomes. Proceedings of the National Academy of Sciences of the United States of America, 112(29), pp. 9112-9117. (doi: 10.1073/pnas.1505411112) (PMID:2615048) (PMCID:PMC4517229)

Srivastava, Anubhav, Creek, Darren J., Evans, Krystal J., De Souza, David, Schofield, Louis, Muller, Sylke, Barrett, Michael P. ORCID: https://orcid.org/0000-0001-9447-3519, McConville, Malcolm J. and Waters, Andrew P. ORCID: https://orcid.org/0000-0001-8900-2982 (2015) Host reticulocytes provide metabolic reservoirs that can be exploited by malaria parasites. PLoS Pathogens, 11(6), e1004882. (doi: 10.1371/journal.ppat.1004882) (PMID:26042734) (PMCID:PMC4456406)

de Macêdo, Juan P., Schumann Burkard, Gabriela, Niemann, Moritz, Barrett, Michael P. ORCID: https://orcid.org/0000-0001-9447-3519, Vial, Henri, Mäser, Pascal, Roditi, Isabel, Schneider, André and Bütikofer, Peter (2015) An atypical mitochondrial carrier that mediates drug action in Trypanosoma brucei. PLoS Pathogens, 11(5), e1004875. (doi: 10.1371/journal.ppat.1004875) (PMID:25946070) (PMCID:PMC4422618)

Trochine, A., Creek, D.J., Faral-Tello, P., Barrett, M.P. ORCID: https://orcid.org/0000-0001-9447-3519 and Robello, C. (2015) Bestatin induces specific changes in trypanosoma cruzi dipeptide pool. Antimicrobial Agents and Chemotherapy, 59(5), pp. 2921-2925. (doi: 10.1128/AAC.05046-14) (PMID:25712359)

Coles, Jonathan A., Myburgh, Elmarie ORCID: https://orcid.org/0000-0002-2007-5902, Ritchie, Ryan, Hamilton, Alana, Rodgers, Jean ORCID: https://orcid.org/0000-0002-2093-3882, Mottram, Jeremy C. ORCID: https://orcid.org/0000-0001-5574-3766, Barrett, Michael P. ORCID: https://orcid.org/0000-0001-9447-3519 and Brewer, James M. ORCID: https://orcid.org/0000-0001-7933-0915 (2015) Intravital imaging of a massive lymphocyte response in the cortical dura of mice after peripheral infection by trypanosomes. PLoS Neglected Tropical Diseases, 9(4), e0003714. (doi: 10.1371/journal.pntd.0003714) (PMID:25881126) (PMCID:PMC4400075)

Creek, D. J. et al. (2015) Probing the metabolic network in bloodstream-form Trypanosoma brucei using untargeted metabolomics with stable isotope labelled glucose. PLoS Pathogens, 11(3), e1004689. (doi: 10.1371/journal.ppat.1004689) (PMID:25775470) (PMCID:PMC4361558)

van der Hooft, Justin ORCID: https://orcid.org/0000-0002-9340-5511, Ridder, Lars, Barrett, Michael P. ORCID: https://orcid.org/0000-0001-9447-3519 and Burgess, Karl V. (2015) Enhanced acylcarnitine annotation in high-resolution mass spectrometry data: fragmentation analysis for the classification and annotation of acylcarnitines. Frontiers in Bioengineering and Biotechnology, 3, p. 26. (doi: 10.3389/fbioe.2015.00026) (PMID:25806366) (PMCID:PMC4353373)

Alkhaldi, A.A.M., Creek, D.J., Ibrahim, H., Kim, D.-H., Quashie, N.B., Burgess, K.E., Changtam, C., Barrett, M.P. ORCID: https://orcid.org/0000-0001-9447-3519, Suksamrarn, A. and De Koning, H.P. ORCID: https://orcid.org/0000-0002-9963-1827 (2015) Potent Trypanocidal curcumin analogs bearing a monoenone linker motif act on Trypanosoma brucei by forming an adduct with Trypanothione. Molecular Pharmacology, 87(3), pp. 451-464. (doi: 10.1124/mol.114.096016) (PMID:25527638)

Shameer, S. et al. (2015) TrypanoCyc: a community-led biochemical pathways database for Trypanosoma brucei. Nucleic Acids Research, 43(D1), D637-D644. (doi: 10.1093/nar/gku944) (PMID:25300491) (PMCID:PMC4384016)

Hai, Yang, Kerkhoven, Eduard J., Barrett, Michael ORCID: https://orcid.org/0000-0001-9447-3519 and Christianson, David W. (2015) Crystal structure of an arginase-like protein fromtrypanosoma bruceithat evolved without a binuclear manganese cluster. Biochemistry, 54(2), pp. 458-471. (doi: 10.1021/bi501366a) (PMID:25536859)

Vincent, I.M. ORCID: https://orcid.org/0000-0003-2663-4389 and Barrett, M.B. ORCID: https://orcid.org/0000-0001-9447-3519 (2015) Metabolomic-based strategies for anti-parasite drug discovery. Journal of Biomolecular Screening, 20(1), pp. 44-55. (doi: 10.1177/1087057114551519) (PMID:25281738)

2014

Giordani, Federica ORCID: https://orcid.org/0000-0001-9964-281X, Buschini, Annamaria, Baliani, Alessandro, Kaiser, Marcel, Brun, Reto, Barrett, Michael P. ORCID: https://orcid.org/0000-0001-9447-3519, Pellacani, Claudia, Poli, Paola and Gilbert, Ian H. (2014) Characterization of a melamino nitroheterocycle as a potential lead for the treatment of human African trypanosomiasis. Antimicrobial Agents and Chemotherapy, 58(10), pp. 5747-5757. (doi: 10.1128/AAC.01449-13)

Achcar, Fiona ORCID: https://orcid.org/0000-0001-8792-7615, Kerkhoven, Eduard J. and Barrett, Michael P ORCID: https://orcid.org/0000-0001-9447-3519 (2014) Trypanosoma brucei: meet the system. Current Opinion in Microbiology, 20, pp. 162-169. (doi: 10.1016/j.mib.2014.06.007)

Bourquin, Yannyk, Syed, Abeer, Reboud, Julien ORCID: https://orcid.org/0000-0002-6879-8405, Ranford-Cartwright, Lisa C. ORCID: https://orcid.org/0000-0003-1992-3940, Barrett, Michael P. ORCID: https://orcid.org/0000-0001-9447-3519 and Cooper, Jonathan M. ORCID: https://orcid.org/0000-0002-2358-1050 (2014) Rare-cell enrichment by a rapid, label-free, ultrasonic isopycnic technique for medical diagnostics. Angewandte Chemie (International Edition), 53(22), pp. 5587-5590. (doi: 10.1002/anie.201310401) (PMID:24677583) (PMCID:PMC4232275)

Munday, J. C. et al. (2014) Trypanosoma brucei aquaglyceroporin 2 is a high-affinity transporter for pentamidine and melaminophenyl arsenic drugs and the main genetic determinant of resistance to these drugs. Journal of Antimicrobial Chemotherapy, 69(3), pp. 651-663. (doi: 10.1093/jac/dkt442) (PMID:24235095) (PMCID:PMC3922157)

Giordani, Federica ORCID: https://orcid.org/0000-0001-9964-281X, Munde, Manoj, Wilson, W. David, Ismail, Mohamed A., Kumar, Arvind, Boykin, David W. and Barrett, Michael P. ORCID: https://orcid.org/0000-0001-9447-3519 (2014) Green fluorescent diamidines as diagnostic probes for trypanosomes. Antimicrobial Agents and Chemotherapy, 58(3), pp. 1793-1796. (doi: 10.1128/AAC.02024-13)

Barrett, M.P. ORCID: https://orcid.org/0000-0001-9447-3519, Nikkhah, D., Gilbert, Philip and Dheansa, Baljit (2014) Why aren’t we doing more to safeguard vulnerable adults from thermal injuries? Burns, 40(2), pp. 360-361. (doi: 10.1016/j.burns.2013.08.018) (PMID:24035041)

Chokkathukalam, Achuthanunni, Kim, Dong-Hyun, Barrett, Michael P. ORCID: https://orcid.org/0000-0001-9447-3519, Breitling, Rainer ORCID: https://orcid.org/0000-0001-7173-0922 and Creek, Darren J. (2014) Stable isotope-labeling studies in metabolomics: new insights into structure and dynamics of metabolic networks. Bioanalysis, 6(4), pp. 511-524. (doi: 10.4155/bio.13.348) (PMID:24568354) (PMCID:PMC4048731)

Kremer, Clemens, Witte, Christian, Neale, Steven L. ORCID: https://orcid.org/0000-0002-4588-276X, Reboud, Julien ORCID: https://orcid.org/0000-0002-6879-8405, Barrett, Michael P. ORCID: https://orcid.org/0000-0001-9447-3519 and Cooper, Jonathan M. ORCID: https://orcid.org/0000-0002-2358-1050 (2014) Shape-dependent optoelectronic cell lysis. Angewandte Chemie (International Edition), 53(3), pp. 842-846. (doi: 10.1002/anie.201307751) (PMID:24402800) (PMCID:PMC4441254)

Barrett, Michael P. ORCID: https://orcid.org/0000-0001-9447-3519 and Croft, Simon L. (2014) Emerging paradigms in anti-infective drug design. Parasitology, 141(1), pp. 1-7. (doi: 10.1017/S0031182013001224)

Creek, Darren J. and Barrett, Michael P. ORCID: https://orcid.org/0000-0001-9447-3519 (2014) Determination of antiprotozoal drug mechanisms by metabolomics approaches. Parasitology, 141(1), pp. 83-92. (doi: 10.1017/S0031182013000814)

Achcar, F. et al. (2014) The silicon trypanosome: a test case of iterative model extension in systems biology. Advances in Microbial Physiology, 64, pp. 115-143. (doi: 10.1016/B978-0-12-800143-1.00003-8) (PMID:24797926) (PMCID:PMC4773886)

Giordani, Federica ORCID: https://orcid.org/0000-0001-9964-281X, Mwenechanya, Roy and Barrett, Michael ORCID: https://orcid.org/0000-0001-9447-3519 (2014) Advances in understanding and treatment of human African trypanosomiasis: divergent diseases caused by distinct parasites. In: Padmanabhan, Sandosh (ed.) Handbook of Pharmacogenomics and Stratified Medicine. Academic Press, pp. 901-917. ISBN 9780123868824 (doi: 10.1016/B978-0-12-386882-4.00039-6)

Khalaf, Abedawn I., Huggan, Judith K., Suckling, Colin J., Gibson, Colin L., Stewart, Kirsten, Giordani, Federica ORCID: https://orcid.org/0000-0001-9964-281X, Barrett, Michael P. ORCID: https://orcid.org/0000-0001-9447-3519, Wong, Pui Ee, Barrack, Keri L. and Hunter, William N. (2014) Structure-based design and synthesis of antiparasitic pyrrolopyrimidines targeting pteridine reductase 1. Journal of Medicinal Chemistry, 57(15), pp. 6479-6494. (doi: 10.1021/jm500483b)

Oppenheim, R. D. et al. (2014) BCKDH: the missing link in apicomplexan mitochondrial metabolism is required for full virulence of Toxoplasma gondii and Plasmodium berghei. PLoS Pathogens, 10(7), e1004263. (doi: 10.1371/journal.ppat.1004263) (PMID:25032958) (PMCID:PMC4102578)

Trochine, Andrea, Creek, Darren J., Faral-Tello, Paula, Barrett, Michael P. ORCID: https://orcid.org/0000-0001-9447-3519 and Robello, Carlos (2014) Benznidazole biotransformation and multiple targets in Trypanosoma cruzi revealed by metabolomics. PLoS Neglected Tropical Diseases, 8(5), e2844. (doi: 10.1371/journal.pntd.0002844)

2013

Kerkhoven, E. J. et al. (2013) Handling uncertainty in dynamic models: the pentose phosphate pathway in trypanosoma brucei. PLoS Computational Biology, 9(12), e1003371. (doi: 10.1371/journal.pcbi.1003371) (PMID:24339766) (PMCID:PMC3854711)

Munday, J.C. ORCID: https://orcid.org/0000-0001-7792-2749, Rojas López, K.E., Eze, A.A., Delespaux, V., Van Den Abbeele, J., Rowan, T., Barrett, M.P. ORCID: https://orcid.org/0000-0001-9447-3519, Morrison, L.J. and De Koning, H.P. ORCID: https://orcid.org/0000-0002-9963-1827 (2013) Functional expression of TcoAT1 reveals it to be a P1-type nucleoside transporter with no capacity for diminazene uptake. International Journal for Parasitology: Drugs and Drug Resistance, 3, pp. 69-76. (doi: 10.1016/j.ijpddr.2013.01.004)

Millerioux, Y. et al. (2013) The threonine degradation pathway of the Trypanosoma brucei procyclic form: the main carbon source for lipid biosynthesis is under metabolic control. Molecular Microbiology, 90(1), pp. 114-129. (doi: 10.1111/mmi.12351) (PMID:23899193) (PMCID:PMC4034587)

Achcar, F. ORCID: https://orcid.org/0000-0001-8792-7615, Barrett, M.P. ORCID: https://orcid.org/0000-0001-9447-3519 and Breitling, R. ORCID: https://orcid.org/0000-0001-7173-0922 (2013) Explicit consideration of topological and parameter uncertainty gives new insights into a well-established model of glycolysis. FEBS Journal, 280(18), pp. 4640-4651. (doi: 10.1111/febs.12436) (PMID:23865459) (PMCID:PMC4768353)

Barrett, M.P. ORCID: https://orcid.org/0000-0001-9447-3519, Gemmell, C.G. and Suckling, C.J. (2013) Minor groove binders as anti-infective agents. Pharmacology and Therapeutics, 139(1), pp. 12-23. (doi: 10.1016/j.pharmthera.2013.03.002)

Creek, Darren J., Nijagal, Brunda, Kim, Dong-Hyun, Rojas, Federico, Matthews, Keith R. and Barrett, Michael P. ORCID: https://orcid.org/0000-0001-9447-3519 (2013) Metabolomics guides rational development of a simplified cell culture medium for drug screening against Trypanosoma brucei. Antimicrobial Agents and Chemotherapy, 57(6), pp. 2768-2779. (doi: 10.1128/AAC.00044-13)

Kim, D.-H. and Barrett, M.P. ORCID: https://orcid.org/0000-0001-9447-3519 (2013) Metabolite-dependent regulation of gene expression in trypanosoma brucei. Molecular Microbiology, 88(5), pp. 841-845. (doi: 10.1111/mmi.12243)

Limenitakis, J., Oppenheim, R.D., Creek, D.J., Foth, B.J., Barrett, M.P. ORCID: https://orcid.org/0000-0001-9447-3519 and Soldati-Favre, D. (2013) The 2-methylcitrate cycle is implicated in the detoxification of propionate inToxoplasma gondii. Molecular Microbiology, 87(4), pp. 894-908. (doi: 10.1111/mmi.12139)

Chokkathukalam, A., Jankevics, A., Creek, D.J., Achcar, F., Barrett, M.P. ORCID: https://orcid.org/0000-0001-9447-3519 and Breitling, R. ORCID: https://orcid.org/0000-0001-7173-0922 (2013) mzMatch-ISO: an R tool for the annotation and relative quantification of isotope-labelled mass spectrometry data. Bioinformatics, 29(2), pp. 281-283. (doi: 10.1093/bioinformatics/bts674) (PMID:23162054) (PMCID:PMC3546800)

Creek, D.J., Vincent, I.M. ORCID: https://orcid.org/0000-0003-2663-4389 and Barrett, M.P. ORCID: https://orcid.org/0000-0001-9447-3519 (2013) Pharmacological metabolomics in trypanosomes. In: Jäger, T., Koch, O. and Flohé, L. (eds.) Trypanosomatid Diseases. Series: Drug discovery in infectious diseases (4). John Wiley and Sons, Inc.: Weinheim, pp. 37-56. ISBN 9783527670390 (doi: 10.1002/9783527670383.ch3)

De Muylder, G. et al. (2013) A trypanosoma brucei kinesin heavy chain promotes parasite growth by triggering host arginase activity. PLoS Pathogens, 9(10), e1003731. (doi: 10.1371/journal.ppat.1003731)

Myburgh, E. ORCID: https://orcid.org/0000-0002-2007-5902, Coles, J.A., Ritchie, R., Kennedy, P.G.E., McLatchie, A., Rodgers, J. ORCID: https://orcid.org/0000-0002-2093-3882, Taylor, M., Barrett, M. ORCID: https://orcid.org/0000-0001-9447-3519, Brewer, J. ORCID: https://orcid.org/0000-0001-7933-0915 and Mottram, J.C. ORCID: https://orcid.org/0000-0001-5574-3766 (2013) In vivo imaging of trypanosome-brain interactions and development of a rapid screening test for drugs against CNS stage trypanosomiasis. PLoS Neglected Tropical Diseases, 7(8), e2384. (doi: 10.1371/journal.pntd.0002384)

2012

Creek, D.J., Chokkathukalam, A., Jankevics, A., Burgess, K.E.V., Breitling, R. ORCID: https://orcid.org/0000-0001-7173-0922 and Barrett, M.P. ORCID: https://orcid.org/0000-0001-9447-3519 (2012) Stable isotope-assisted metabolomics for network-wide metabolic pathway elucidation. Analytical Chemistry, 84(20), pp. 8442-8447. (doi: 10.1021/ac3018795) (PMID:22946681) (PMCID:PMC3472505)

Clark, R.L., Clements, C.J., Barrett, M.P. ORCID: https://orcid.org/0000-0001-9447-3519, Mackay, S.P., Rathnam, R.P., Owusu-Dapaah, G., Spencer, J. and Huggan, J.K. (2012) Identification and development of the 1,4-benzodiazepin-2-one and quinazoline-2,4-dione scaffolds as submicromolar inhibitors of HAT. Bioorganic and Medicinal Chemistry, 20(20), pp. 6019-6033. (doi: 10.1016/j.bmc.2012.08.049)

Baker, Nicola, Glover, Lucy, Munday, Jane C. ORCID: https://orcid.org/0000-0001-7792-2749, Aguinaga Andres, David, Barrett, Michael P. ORCID: https://orcid.org/0000-0001-9447-3519, De Koning, Harry P. ORCID: https://orcid.org/0000-0002-9963-1827 and Horn, David (2012) Aquaglyceroporin 2 controls susceptibility to melarsoprol and pentamidine in African trypanosomes. Proceedings of the National Academy of Sciences of the United States of America, 109(27), pp. 10996-11001. (doi: 10.1073/pnas.1202885109)

Creek, D.J., Jankevics, A., Burgess, K.E.V., Breitling, R. ORCID: https://orcid.org/0000-0001-7173-0922 and Barrett, M.P. ORCID: https://orcid.org/0000-0001-9447-3519 (2012) IDEOM: an excel interface for analysis of LC-MS based metabolomics data. Bioinformatics, 28(7), pp. 1048-1049. (doi: 10.1093/bioinformatics/bts069) (PMID:22308147)

Achcar, F., Kerkhoven, E.J., SilicoTryp Consortium, Bakker, B.M., Barrett, M.P. ORCID: https://orcid.org/0000-0001-9447-3519 and Breitling, R. ORCID: https://orcid.org/0000-0001-7173-0922 (2012) Dynamic modelling under uncertainty: the case of Trypanosoma brucei energy metabolism. PLoS Computational Biology, 8(1), e1002352. (doi: 10.1371/journal.pcbi.1002352) (PMID:22379410) (PMCID:PMC3269904)

Barrett, M.P. ORCID: https://orcid.org/0000-0001-9447-3519 and Croft, S.L. (2012) Management of trypanosomiasis and leishmaniasis. British Medical Bulletin, 104(1), pp. 175-196. (doi: 10.1093/bmb/lds031)

Bringaud, F., Barrett, M. ORCID: https://orcid.org/0000-0001-9447-3519 and Zilberstein, D. (2012) Multiple roles of proline transport and metabolism in trypanosomatids. Frontiers in Bioscience, 17(1), p. 349. (doi: 10.2741/3931)

Creek, D., Anderson, J. ORCID: https://orcid.org/0000-0001-7290-6635, McConville, M.J. and Barrett, M.P. ORCID: https://orcid.org/0000-0001-9447-3519 (2012) Metabolomic analysis of trypanosomatid protozoa. Molecular and Biochemical Parasitology, 181(2), pp. 73-84. (doi: 10.1016/j.molbiopara.2011.10.003)

Menachery, A., Kremer, C., Wong, P.E., Carlsson, A., Neale, S.L. ORCID: https://orcid.org/0000-0002-4588-276X, Barrett, M.P. ORCID: https://orcid.org/0000-0001-9447-3519 and Cooper, J.M. ORCID: https://orcid.org/0000-0002-2358-1050 (2012) Counterflow dielectrophoresis for trypanosome enrichment and detection in blood. Scientific Reports, 2, 775. (doi: 10.1038/srep00775) (PMID:23105971) (PMCID:PMC3481117)

Vincent, I.M. ORCID: https://orcid.org/0000-0003-2663-4389, Creek, D.J., Burgess, K., Woods, D.J., Burchmore, R.J.S. ORCID: https://orcid.org/0000-0003-1663-9004 and Barrett, M.P. ORCID: https://orcid.org/0000-0001-9447-3519 (2012) Untargeted metabolomics reveals a lack of synergy between nifurtimox and eflornithine against trypanosoma brucei. PLoS Neglected Tropical Diseases, 6(5), e1618. (doi: 10.1371/journal.pntd.0001618) (PMID:22563508) (PMCID:PMC3341325)

Zhang, T., Creek, D.J., Barrett, M.P. ORCID: https://orcid.org/0000-0001-9447-3519, Blackburn, G. and Watson, D.G. (2012) Evaluation of coupling reversed phase, aqueous normal phase, and hydrophilic interaction liquid chromatography with orbitrap mass spectrometry for metabolomic studies of human urine. Analytical Chemistry, 84(4), pp. 1994-2001. (doi: 10.1021/ac2030738)

2011

Burgess, K., Creek, D., Dewsbury, P., Cook, K. and Barrett, M.P. ORCID: https://orcid.org/0000-0001-9447-3519 (2011) Semi-targeted analysis of metabolites using capillary-flow ion chromatography coupled to high-resolution mass spectrometry. Rapid Communications in Mass Spectrometry, 25(22), pp. 3447-3452. (doi: 10.1002/rcm.5247)

Leader, D.P. ORCID: https://orcid.org/0000-0002-0635-1843, Burgess, K., Creek, D. and Barrett, M.P. ORCID: https://orcid.org/0000-0001-9447-3519 (2011) Pathos: a web facility that uses metabolic maps to display experimental changes in metabolites identified by mass spectrometry. Rapid Communications in Mass Spectrometry, 25(22), pp. 3422-3426. (doi: 10.1002/rcm.5245)

Barrett, M.P. ORCID: https://orcid.org/0000-0001-9447-3519, Vincent, I.M. ORCID: https://orcid.org/0000-0003-2663-4389, Burchmore, R.J.S. ORCID: https://orcid.org/0000-0003-1663-9004, Kazibwe, A.J.N. and Matovu, E. (2011) Drug resistance in human African trypanosomiasis. Future Microbiology, 6(9), pp. 1037-1047. (doi: 10.2217/fmb.11.88) (PMID:21958143)

Teka, I. A. et al. (2011) The diamidine diminazene aceturate is a substrate for the high-affinity pentamidine transporter: implications for the development of high resistance levels in trypanosomes. Molecular Pharmacology, 80(1), pp. 110-116. (doi: 10.1124/mol.111.071555)

Holm, Stefan H., Beech, Jason P., Barrett, Michael P. ORCID: https://orcid.org/0000-0001-9447-3519 and Tegenfeldt, Jonas O. (2011) Separation of parasites from human blood using deterministic lateral displacement. Lab on a Chip, 11(7), pp. 1326-1332. (doi: 10.1039/c0lc00560f)

Goodwin, R.J.A., Pitt, A.R., Harrison, D., Weidt, S.K., Langridge-Smith, P.R.R., Barrett, M.P. ORCID: https://orcid.org/0000-0001-9447-3519 and Mackay, C.L. (2011) Matrix-free mass spectrometric imaging using laser desorption ionisation Fourier transform ion cyclotron resonance mass spectrometry. Rapid Communications in Mass Spectrometry, 25(7), pp. 969-972. (doi: 10.1002/rcm.4939)

Spencer, J., Rathnam, R.P., Harvey, A.L., Clements, C.J., Clark, R.L., Barrett, M.P. ORCID: https://orcid.org/0000-0001-9447-3519, Wong, P.E., Male, L., Coles, S.J. and Mackay, S.P. (2011) Synthesis and biological evaluation of 1,4-benzodiazepin-2-ones with antitrypanosomal activity. Bioorganic and Medicinal Chemistry, 19(5), pp. 1802-1815. (doi: 10.1016/j.bmc.2011.01.010)

Brun, R., Don, R., Jacobs, R.T., Wang, M.Z. and Barrett, M.P. ORCID: https://orcid.org/0000-0001-9447-3519 (2011) Development of novel drugs for human African trypanosomiasis. Future Microbiology, 6(6), pp. 677-691. (doi: 10.2217/fmb.11.44)

Creek, D.J., Jankevics, A., Breitling, R. ORCID: https://orcid.org/0000-0001-7173-0922, Watson, D.G., Barrett, M.P. ORCID: https://orcid.org/0000-0001-9447-3519 and Burgess, K.E.V. (2011) Toward global metabolomics snalysis with Hydrophilic Interaction Liquid Chromatography–Mass Spectrometry: improved metabolite identification by retention time prediction. Analytical Chemistry, 83(22), pp. 8703-8710. (doi: 10.1021/ac2021823)

Rodgers, Jean ORCID: https://orcid.org/0000-0002-2093-3882, Jones, Amy, Gibaud, Stephane, Bradley, Barbara, McCabe, Chris ORCID: https://orcid.org/0000-0003-3111-031X, Barrett, Michael P. ORCID: https://orcid.org/0000-0001-9447-3519, Gettinby, George and Kennedy, Peter G.E. (2011) Melarsoprol cyclodextrin inclusion complexes as promising oral candidates for the treatment of human African trypanosomiasis. PLoS Neglected Tropical Diseases, 5(9), e1308. (doi: 10.1371/journal.pntd.0001308)

Rogers, S. ORCID: https://orcid.org/0000-0003-3578-4477, Scheltema, R.A., Barrett, M. ORCID: https://orcid.org/0000-0001-9447-3519 and Breitling, R. ORCID: https://orcid.org/0000-0001-7173-0922 (2011) Bayesian approaches for mass spectrometry-based metabolomics. In: Stumpf, M.P.H., Balding, D.J. and Girolami, M. (eds.) Handbook of Statistical Systems Biology. John Wiley & Sons: Chichester, UK, pp. 467-476. ISBN 9780470710869 (doi: 10.1002/9781119970606.ch24)

Stoffel, S.A., Alibu, V.P., Hubert, J., Ebikeme, C., Portais, J.C., Bringaud, F., Schweingruber, M.E. and Barrett, M. ORCID: https://orcid.org/0000-0001-9447-3519 (2011) Transketolase in Trypanosoma brucei. Molecular and Biochemical Parasitology, 179(1), pp. 1-7. (doi: 10.1016/j.molbiopara.2011.04.006)

Ward, C.P., Wong, P.E., Burchmore, R.J.S. ORCID: https://orcid.org/0000-0003-1663-9004, De Koning, H.P. ORCID: https://orcid.org/0000-0002-9963-1827 and Barrett, M.P. ORCID: https://orcid.org/0000-0001-9447-3519 (2011) Trypanocidal furamidine analogues: influence of pyridine nitrogens on trypanocidal activity, transport kinetics, and resistance patterns. Antimicrobial Agents and Chemotherapy, 55(5), pp. 2352-2361. (doi: 10.1128/AAC.01551-10)

2010

Barrett, Michael P. ORCID: https://orcid.org/0000-0001-9447-3519 (2010) Potential new drugs for human African trypanosomiasis: some progress at last. Current Opinion in Infectious Diseases, 23(6), pp. 603-608. (doi: 10.1097/QCO.0b013e32833f9fd0)

Naula, C.M. ORCID: https://orcid.org/0000-0003-1165-693X, Logan, F.M., Wong, P.E., Barrett, M.P. ORCID: https://orcid.org/0000-0001-9447-3519 and Burchmore, R.J. ORCID: https://orcid.org/0000-0003-1663-9004 (2010) A glucose transporter can mediate ribose uptake: definition of residues that confer substrate specificity in a sugar transporter. Journal of Biological Chemistry, 285(39), pp. 29721-29728. (doi: 10.1074/jbc.M110.106815)

Bakker, B., Krauth-Siegel, R.L., Clayton, C., Matthews, K., Girolami, M., Westerhoff, H.V., Michels, P.A.M., Breitling, R. ORCID: https://orcid.org/0000-0001-7173-0922 and Barrett, M.P. ORCID: https://orcid.org/0000-0001-9447-3519 (2010) The silicon trypanosome. Parasitology, 137(9), pp. 1333-1341. (doi: 10.1017/S0031182010000466) (PMID:20444304)

Barrett, M.P., Bakker, B.M. and Breitling, R. (2010) Metabolomic systems biology of trypanosomes. Parasitology, 137(9), pp. 1285-1290. (doi: 10.1017/S003118201000017X) (PMID:20158937)

Paine, M.F. et al. (2010) Diamidines for human African trypanosomiasis. Current Opinion in Investigational Drugs, 11(8), pp. 876-883.

Ruda, Gian Filippo, Campbell, Gordon, Alibu, Vincent P., Barrett, M.P. ORCID: https://orcid.org/0000-0001-9447-3519, Brenk, Ruth and Gilbert, Ian H. (2010) Virtual fragment screening for novel inhibitors of 6-phosphogluconate dehydrogenase. Bioorganic and Medicinal Chemistry, 18(14), pp. 5056-5062. (doi: 10.1016/j.bmc.2010.05.077)

Stewart, M.L. et al. (2010) Multiple genetic mechanisms lead to loss of functional TbAT1 expression in drug-resistant trypanosomes. Eukaryotic Cell, 9(2), pp. 336-343. (doi: 10.1128/EC.00200-09) (PMID:19966032) (PMCID:PMC2823006)

Conti, P., Pinto, A., Wong, P.E., Major, L.L., Tamborini, L., Iannuzzi, M.C., De Micheli, C., Barrett, M.P. ORCID: https://orcid.org/0000-0001-9447-3519 and Smith, T.K. (2010) Synthesis and in vitro/in vivo Evaluation of the Antitrypanosomal Activity of 3-Bromoacivicin, a Potent CTP Synthetase Inhibitor. ChemMedChem, 6(2), pp. 329-333. (doi: 10.1002/cmdc.201000417)

Cottret, L., Wildridge, D., Vinson, F., Barrett, M.P. ORCID: https://orcid.org/0000-0001-9447-3519, Charles, H., Sagot, M.-F. and Jourdan, F. (2010) MetExplore: a web server to link metabolomic experiments and genome-scale metabolic networks. Nucleic Acids Research, 38(Suppl), W132-W137. (doi: 10.1093/nar/gkq312)

González, D., Pérez, J.L., Serrano, M.L., Igoillo-Esteve, M., Cazzulo, J.J., Barrett, M.P. ORCID: https://orcid.org/0000-0001-9447-3519, Bubis, J. and Mendoza-León, A. (2010) The 6-Phosphogluconate Dehydrogenase of Leishmania (Leishmania) mexicana: Gene Characterization and Protein Structure Prediction. Journal of Molecular Microbiology and Biotechnology, 19(4), pp. 213-223. (doi: 10.1159/000320697)

Jourdan, Fabien, Cottret, Ludovic, Huc, Laurence, Wildridge, David, Scheltema, Richard, Hillenweck, Anne, Barrett, M.P., Zalko, Daniel, Watson, David G. and Debrauwer, Laurent (2010) Use of reconstituted metabolic networks to assist in metabolomic data visualization and mining. Metabolomics, 6(2), pp. 312-321. (doi: 10.1007/s11306-009-0196-9) (PMID:20526351) (PMCID:PMC2874485)

Klee, Nina, Wong, Pui Ee, Baragana, Beatriz, Mazouni, Farah El, Phillips, Margaret A., Barrett, M.P. ORCID: https://orcid.org/0000-0001-9447-3519 and Gilbert, Ian H. (2010) Selective delivery of 2-hydroxy APA to Trypanosoma brucei using the melamine motif. Bioorganic and Medicinal Chemistry Letters, 20(15), pp. 4364-4366. (doi: 10.1016/j.bmcl.2010.06.070)

Ruda, G.F., Wong, P.E., Alibu, V.P., Norval, S., Read, K.D., Barrett, M.P. ORCID: https://orcid.org/0000-0001-9447-3519 and Gilbert, I.H. (2010) Aryl phosphoramidates of 5-phospho erythronohydroxamic acid, a new class of potent Trypanocidal compounds. Journal of Medicinal Chemistry, 53(16), pp. 6071-6078. (doi: 10.1021/jm1004754)

Vincent, I.M. ORCID: https://orcid.org/0000-0003-2663-4389, Creek, D., Watson, D.G., Kamleh, M.A., Woods, D.J., Wong, P.E., Burchmore, R.J.S. ORCID: https://orcid.org/0000-0003-1663-9004 and Barrett, M.P. ORCID: https://orcid.org/0000-0001-9447-3519 (2010) A molecular mechanism for eflornithine resistance in African trypanosomes. PLoS Pathogens, 6(11), e1001204. (doi: 10.1371/journal.ppat.1001204) (PMID:21124824) (PMCID:PMC2991269)

Ward, Christopher P., Burgess, Karl E.V., Burchmore, R.J.S. ORCID: https://orcid.org/0000-0003-1663-9004, Barrett, M.P. ORCID: https://orcid.org/0000-0001-9447-3519 and De Koning, H.P. (2010) A fluorescence-based assay for the uptake of CPD0801 (DB829) by African trypanosomes. Molecular and Biochemical Parasitology, 174(2), pp. 145-149. (doi: 10.1016/j.molbiopara.2010.07.002)

2009

Kazibwe, A.J.N., Nerima, B., De Koning, H.P. ORCID: https://orcid.org/0000-0002-9963-1827, Mäser, P., Barrett, M.P. ORCID: https://orcid.org/0000-0001-9447-3519 and Matovu, E. (2009) Genotypic status of the TbAT1/P2 adenosine transporter of Trypanosoma brucei gambiense isolates from northwestern Uganda following melarsoprol withdrawal. PLoS Neglected Tropical Diseases, 3(9), e523. (doi: 10.1371/journal.pntd.0000523)

Mukhopadhyay, A., Chen, C.Y., Doerig, C., Henriquez, F.L., Roberts, C.W. and Barrett, M.P. ORCID: https://orcid.org/0000-0001-9447-3519 (2009) The Toxoplasma gondii Plastid replication and Repair Enzyme complex, PREX. Parasitology, 136(7), pp. 747-755. (doi: 10.1017/S0031182009006027)

Rodgers, J. ORCID: https://orcid.org/0000-0002-2093-3882, Stone, T.W., Barrett, M.P., Bradley, B.M. and Kennedy, P.G.E. (2009) Kynurenine pathway inhibition reduces central nervous system inflammation in a model of human African trypanosomiasis. Brain, 132(5), pp. 1259-1267. (doi: 10.1093/brain/awp074)

Jhingran, A., Chawla, B., Saxena, S., Barrett, M.P. ORCID: https://orcid.org/0000-0001-9447-3519 and Madhubala, R. (2009) Paromomycin: Uptake and resistance in Leishmania donovani. Molecular and Biochemical Parasitology, 164(2), pp. 111-117. (doi: 10.1016/j.molbiopara.2008.12.007)

Wenzel, N., Wong, P.E., Maes, L., Muller, T.J., Krauth-Siegel, R.L., Barrett, M.P. ORCID: https://orcid.org/0000-0001-9447-3519 and Davioud-Charvet, E. (2009) Unsaturated mannich bases active against multidrug-resistant Trypanosoma brucei brucei strains. ChemMedChem, 4(3), pp. 339-351. (doi: 10.1002/cmdc.200800360)

Baliani, A., Peal, V., Gros, L., Brun, R., Kaiser, M., Barrett, M.P. ORCID: https://orcid.org/0000-0001-9447-3519 and Gilbert, I.H. (2009) Novel functionalized melamine-based nitroheterocycles: synthesis and activity against trypanosomatid parasites. Organic and Biomolecular Chemistry, 7(6), pp. 1154-1166. (doi: 10.1039/b813394h)

Chollet, C., Baliani, A., Wong, P.E., Barrett, M.P. ORCID: https://orcid.org/0000-0001-9447-3519 and Gilbert, I.H. (2009) Targeted delivery of compounds to Trypanosoma brucei using the melamine motif. Bioorganic and Medicinal Chemistry, 17(6), pp. 2512-2523. (doi: 10.1016/j.bmc.2009.01.058)

Collar, C.J., Al Salabi, M.I., Stewart, M.L., Barrett, M.P. ORCID: https://orcid.org/0000-0001-9447-3519, Wilson, W.D. and de Koning, H.P. (2009) Predictive computational models of substrate binding by a nucleoside transporter. Journal of Biological Chemistry, 284(49), pp. 34028-34035. (doi: 10.1074/jbc.M109.049726)

2008

Checchi, F., Filipe, J.A.N., Barrett, M.P. ORCID: https://orcid.org/0000-0001-9447-3519 and Chandramohan, D. (2008) The natural progression of gambiense sleeping sickness: what is the evidence? PLoS Neglected Tropical Diseases, 2(12), e303. (doi: 10.1371/journal.pntd.0000303) (PMID:19104656) (PMCID:PMC2602732)

Scheltema, R.A., Kamleh, A., Wildridge, D., Ebikeme, C., Watson, D.G., Barrett, M. ORCID: https://orcid.org/0000-0001-9447-3519, Jansen, R.C. and Breitling, R. (2008) Increasing the mass accuracy of high-resolution LC-MS data using background ions - a case study on the LTQ-Orbitrap. Proteomics, 8(22), pp. 4647-4656. (doi: 10.1002/pmic.200800314)

Kamleh, A., Barrett, M.P. ORCID: https://orcid.org/0000-0001-9447-3519, Wildridge, D., Burchmore, R.J.S. ORCID: https://orcid.org/0000-0003-1663-9004, Scheltema, R.A.. and Watson, D.G. (2008) Metabolomic profiling using Orbitrap Fourier transform mass spectrometry with hydrophilic interaction chromatography: a method with wide applicability to analysis of biomolecules. Rapid Communications in Mass Spectrometry, 22(12), pp. 1912-1918. (doi: 10.1002/rcm.3564)

Coustou, V., Biran, M., Breton, M., Guegan, F., Riviere, L., Plazolles, N., Nolan, D., Barrett, M.P. ORCID: https://orcid.org/0000-0001-9447-3519, Franconi, J.M. and Bringaud, F. (2008) Glucose-induced remodeling of intermediary and energy metabolism in procyclic Trypanosoma brucei. Journal of Biological Chemistry, 283(24), pp. 16342-16354. (doi: 10.1074/jbc.M709592200)

Ebikeme, C.E., Peacock, L., Coustou, V., Riviere, L., Bringaud, F., Gibson, W.C. and Barrett, M.P. (2008) N-acetyl D-glucosamine stimulates growth in procyclic forms of Trypanosoma brucei by inducing a metabolic shift. Parasitology, 135(5), pp. 585-594. (doi: 10.1017/S0031182008004241)

Checchi, F. and Barrett, M.P. (2008) African sleeping sicknesss - Eflornithine should be the drug of choice for stage 2 disease, but resistance must be monitored. British Medical Journal, 336(7646), pp. 679-680. (doi: 10.1136/bmj.39505.490544.BE)

Breitling, R. ORCID: https://orcid.org/0000-0001-7173-0922, Vitkup, D. and Barrett, M.P. (2008) New surveyor tools for charting microbial metabolic maps. Nature Reviews Microbiology, 6, pp. 156-161. (doi: 10.1038/nrmicro1797)

Reid, C.M., Ebikeme, C., Barrett, M.P., Patzewitz, E.M., Muller, S., Robins, D.J. and Sutherland, A. (2008) Synthesis and anti-protozoal activity of C2-substituted polyazamacrocycles. Bioorganic and Medicinal Chemistry Letters, 18(7), pp. 2455-2458. (doi: 10.1016/j.bmcl.2008.02.037)

Arrighi, R. B. G., Ebikeme, C., Jiang, Y., Ranford-Cartwright, L.C. ORCID: https://orcid.org/0000-0003-1992-3940, Barrett, M.P. ORCID: https://orcid.org/0000-0001-9447-3519, Langel, U. and Faye, I. (2008) Cell-Penetrating Peptide TP10 Shows Broad-Spectrum Activity against both Plasmodium falciparum and Trypanosoma brucei brucei. Antimicrobial Agents and Chemotherapy, 52(9), pp. 3414-3417. (doi: 10.1128/AAC.01450-07)

Jourdan, F., Breitling, R., Barrett, M.P. and Gilbert, D. (2008) MetaNetter: inference and visualization of high-resolution metabolomic networks. Bioinformatics, 24(1), pp. 143-145. (doi: 10.1093/bioinformatics/btm536)

Reid, Caroline M., Ebikeme, Charles, Barrett, M.P. ORCID: https://orcid.org/0000-0001-9447-3519, Patzewitz, Eva-Maria, Muller, S., Robins, David J. and Sutherland, Andrew (2008) Synthesis of novel benzamidine- and guanidine-derived polyazamacrocycles: Selective anti-protozoal activity for human African trypanosomiasis. Bioorganic and Medicinal Chemistry Letters, 18(20), pp. 5399-5401. (doi: 10.1016/j.bmcl.2008.09.047)

2007

Sundaramoorthy, Ramasubramanian, Iulek, Jorge, Barrett, Michael P. ORCID: https://orcid.org/0000-0001-9447-3519, Bidet, Olivier, Ruda, Gian Filippo, Gilbert, Ian H. and Hunter, William N. (2007) Crystal structures of a bacterial 6-phosphogluconate dehydrogenase reveal aspects of specificity, mechanism and mode of inhibition by analogues of high-energy reaction intermediates. FEBS Journal, 274(1), pp. 275-286. (doi: 10.1111/j.1742-4658.2006.05585.x)

Barrett, M ORCID: https://orcid.org/0000-0001-9447-3519 (2007) Human African trypanosomiasis: pharmacological re-engagement with a neglected disease. British Journal of Pharmacology, 152(8), pp. 1155-1171. (doi: 10.1038/sj.bjp.0707354)

Naula, C. ORCID: https://orcid.org/0000-0003-1165-693X, Alibu, V., Brock, J., Veitch, N.J. ORCID: https://orcid.org/0000-0002-9583-3915, Burchmore, R.J.S. ORCID: https://orcid.org/0000-0003-1663-9004 and Barrett, M. (2007) A new erythrose 4-phosphate dehydrogenase coupled assay for transketolase. Journal of Biochemical and Biophysical Methods, 70(6), pp. 1185-1187. (doi: 10.1016/j.jprot.2007.11.002)

Ogbunude, POJ, Lamour, N and Barrett, MP ORCID: https://orcid.org/0000-0001-9447-3519 (2007) Molecular cloning, expression and characterization of ribokinase of Leishmania major. Acta Biochimica et Biophysica Sinica, 39, pp. 462-466. (doi: 10.1111/j.1745-7270.2007.00298.x)

2006

Anene, B.M., Ezeokonkwo, R.C., Mmesirionye, T.I., Tettey, J.N.A., Brock, J.M., Barrett, M.P. ORCID: https://orcid.org/0000-0001-9447-3519 and De Koning, H.P. ORCID: https://orcid.org/0000-0002-9963-1827 (2006) A diminazene-resistant strain of Trypanosoma brucei brucei isolated from a dog is cross-resistant to pentamidine in experimentally infected albino rats. Parasitology, 132(1), pp. 127-133. (doi: 10.1017/S0031182005008760)

Barrett, MP ORCID: https://orcid.org/0000-0001-9447-3519 and Gilbert, IH (2006) Targeting of toxic compounds to the trypanosome's interior. Advances in Parasitology, 63, pp. 125-183. (doi: 10.1016/S0065-308X(06)63002-9)

Breitling, R, Ritchie, S, Goodenowe, D, Stewart, ML and Barrett, MP ORCID: https://orcid.org/0000-0001-9447-3519 (2006) Ab initio prediction of metabolic networks using Fourier transform mass spectrometry data. Metabolomics, 2, pp. 155-164. (doi: 10.1007/s11306-006-0029-z)

Dardonville, C, Barrett, MP ORCID: https://orcid.org/0000-0001-9447-3519, Brun, R, Kaiser, M, Tanious, F and Wilson, WD (2006) DNA binding affinity of bisguanidine and bis(2-aminoimidazoline) derivatives with in vivo antitrypanosomal activity. Journal of Medicinal Chemistry, 49, pp. 3748-3752. (doi: 10.1021/jm060295c)

Lanteri, C.A., Stewart, M.L., Brock, J.M., Alibu, V.P., Meshnick, S.R., Tidwell, R.R. and Barrett, M.P. ORCID: https://orcid.org/0000-0001-9447-3519 (2006) Roles for the Trypanosoma brucei P2 transporter in DB75 uptake and resistance. Molecular Pharmacology, 70(5), pp. 1585-1592. (doi: 10.1124/mol.106.024653)

Mukherjee, A, Padmanabhan, PK, Sahani, MH, Barrett, MP ORCID: https://orcid.org/0000-0001-9447-3519 and Madhubala, R (2006) Roles for mitochondria in pentamidine susceptibility and resistance in Leishmania donovani. Molecular and Biochemical Parasitology, 145, pp. 1-10. (doi: 10.1016/j.molbiopara.2005.08.016)

2005

Baliani, A, Bueno, GJ, Stewart, ML, Yardley, V, Brun, R, Barrett, MP ORCID: https://orcid.org/0000-0001-9447-3519 and Gilbert, IH (2005) Design and synthesis of a series of melamine-based nitroheterocycles with activity against trypanosomatid parasites. Journal of Medicinal Chemistry, 48, pp. 5570-5579. (doi: 10.1021/jm050177+)

Besteiro, S, Barrett, MP ORCID: https://orcid.org/0000-0001-9447-3519, Riviere, L and Bringaud, F (2005) Energy generation in insect stages of Trypanosoma brucei: metabolism in flux. Trends in Parasitology, 21, pp. 185-191.

Croft, SL, Barrett, MP ORCID: https://orcid.org/0000-0001-9447-3519 and Urbina, JA (2005) Chemotherapy of trypanosomiases and leishmaniasis. Trends in Parasitology, 21, pp. 508-512. (doi: 10.1016/j.pt.2005.08.026)

Lamour, N, Riviere, L, Coustou, V, Coombs, GH, Barrett, MP ORCID: https://orcid.org/0000-0001-9447-3519 and Bringaud, F (2005) Proline metabolism in procyclic Trypanosoma brucei is down-regulated in the presence of glucose. Journal of Biological Chemistry, 280, pp. 11902-11910. (doi: 10.1074/jbc.M414274200)

Stewart, ML, Boussard, C, Brun, R, Gilbert, IH and Barrett, MP ORCID: https://orcid.org/0000-0001-9447-3519 (2005) Interaction of monobenzamidine-linked trypanocides with the Trypanosoma brucei P2 aminopurine transporter. Antimicrobial Agents and Chemotherapy, 49, pp. 5169-5171. (doi: 10.1128/AAC.49.12.5169-5171.2005)

Stewart, ML, Krishna, S, Burchmore, RJS ORCID: https://orcid.org/0000-0003-1663-9004, Brun, R, de Koning, HP ORCID: https://orcid.org/0000-0002-9963-1827, Boykin, DW, Tidwell, RR, Hall, JE and Barrett, MP ORCID: https://orcid.org/0000-0001-9447-3519 (2005) Detection of arsenical drug resistance in Trypanosoma brucei with a simple fluorescence test. Lancet, 366, pp. 486-487. (doi: 10.1016/S0140-6736(05)66793-1)

2004

Janssen, C.S., Phillips, R.S., Turner, Charles and Barrett, M.P. ORCID: https://orcid.org/0000-0001-9447-3519 (2004) Plasmodium interspersed repeats: the major multigene superfamily of malaria parasites. Nucleic Acids Research, 32(19), pp. 5712-5720. (doi: 10.1093/nar/gkh907)

Azema, L. et al. (2004) Interaction of substituted hexose analogues with the Trypanosoma brucei hexose transporter. Biochemical Pharmacology, 67, pp. 459-467. (doi: 10.1016/j.bcp.2003.09.005)

Dardonville, C, Rinaldi, E, Barrett, MP ORCID: https://orcid.org/0000-0001-9447-3519, Brun, R, Gilbert, IH and Hanau, S (2004) Selective inhibition of Trypanosoma brucei 6-phosphogluconate dehydrogenase by high-energy intermediate and transition-state analogues. Journal of Medicinal Chemistry, 47, pp. 3427-3437. (doi: 10.1021/jm031066i)

de Koning, HP ORCID: https://orcid.org/0000-0002-9963-1827, Anderson, LF, Stewart, M, Burchmore, RJS ORCID: https://orcid.org/0000-0003-1663-9004, Wallace, LJM and Barrett, MP ORCID: https://orcid.org/0000-0001-9447-3519 (2004) The trypanocide diminazene aceturate is accumulated predominantly through the TbAT1 purine transporter: additional insights on diamidine resistance in African trypanosomes. Antimicrobial Agents and Chemotherapy, 48, pp. 1515-1519. (doi: 10.1128/AAC.48.5.1515-1519.2004)

Hanau, S, Rinaldi, E, Dallocchio, F, Gilbert, IH, Dardonville, C, Adams, MJ, Gover, S and Barrett, MP ORCID: https://orcid.org/0000-0001-9447-3519 (2004) 6-phosphogluconate dehydrogenase: A target for drugs in African trypanosomes. Current Medicinal Chemistry, 11, pp. 2639-2650.

Janssen, CS, Phillips, RS, Turner, CMR and Barrett, MP (2004) Plasmodium interspersed repeats: the major multigene superfamily of malaria parasites. Nucleic Acids Research, 32, pp. 5712-5720. (doi: 10.1093/nar/gkh907)

Stewart, M.L., Bueno, G.J., Baliani, A., Klenke, B., Brun, R., Brock, J.M., Gilbert, I,H. and Barrett, M,P, ORCID: https://orcid.org/0000-0001-9447-3519 (2004) Trypanocidal activity of melamine-based nitroheterocycles. Antimicrobial Agents and Chemotherapy, 48(5), pp. 1733-1738. (doi: 10.1128/AAC.48.5.1733-1738.2004)

Veitch, N.V. ORCID: https://orcid.org/0000-0002-9583-3915, Maugeri, D.A., Cazzulo, J.J., Lindqvist, Y. and Barrett, M.P. (2004) Transketolase from Leishmania mexicana has a dual subcellular localization. Biochemical Journal, 382(2), pp. 759-767. (doi: 10.1042/BJ20040459)

2003

Barrett, MP ORCID: https://orcid.org/0000-0001-9447-3519, Burchmore, RJS ORCID: https://orcid.org/0000-0003-1663-9004, Stich, A, Lazzari, JO, Frasch, AC, Cazzulo, JJ and Krishna, S (2003) The trypanosomiases. Lancet, 362(9394), pp. 1469-1480. (doi: 10.1016/S0140-6736(03)14694-6)

Bray, PG, Barrett, MP ORCID: https://orcid.org/0000-0001-9447-3519, Ward, SA and de Koning, HP ORCID: https://orcid.org/0000-0002-9963-1827 (2003) Pentamidine uptake and resistance in pathogenic protozoa: past, present and future. Trends in Parasitology, 19(5), pp. 232-239. (doi: 10.1016/S1471-4922(03)00069-2)

Burchmore, RJS ORCID: https://orcid.org/0000-0003-1663-9004, Rodriguez-Contreras, D, McBride, K, Barrett, MP ORCID: https://orcid.org/0000-0001-9447-3519, Modi, G, Sacks, D and Landfear, SM (2003) Genetic characterization of glucose transporter function in Leishmania mexicana. Proceedings of the National Academy of Sciences of the United States of America, 100(7), pp. 3901-3906. (doi: 10.1073/pnas.0630165100)

Burchmore, RJS ORCID: https://orcid.org/0000-0003-1663-9004, Wallace, LJM, Candlish, D, Al-Salabi, MI, Beal, PR, Barrett, MP ORCID: https://orcid.org/0000-0001-9447-3519, Baldwin, SA and de Koning, HP ORCID: https://orcid.org/0000-0002-9963-1827 (2003) Cloning, heterologous expression, and in situ characterization of the first high affinity nucleobase transporter from a protozoan. Journal of Biological Chemistry, 278(26), pp. 23502-23507. (doi: 10.1074/jbc.M301252200)

Dardonville, C, Rinaldi, E, Hanau, S, Barrett, MP ORCID: https://orcid.org/0000-0001-9447-3519, Brun, R and Gilbert, IH (2003) Synthesis and biological evaluation of substrate-based inhibitors of 6-phosphogluconate dehydrogenase as potential drugs against African trypanosomiasis. Bioorganic and Medicinal Chemistry Letters, 11(14), pp. 3205-3214. (doi: 10.1016/S0968-0896(03)00191-3)

Enanga, B, Ariyanayagam, MR, Stewart, ML and Barrett, MP ORCID: https://orcid.org/0000-0001-9447-3519 (2003) Activity of megazol, a trypanocidal nitroimidazole, is associated with DNA damage. Antimicrobial Agents and Chemotherapy, 47(10), pp. 3368-3370. (doi: 10.1128/AAC.47.10.3368-3370.2003)

Klenke, B, Barrett, MP ORCID: https://orcid.org/0000-0001-9447-3519, Brun, R and Gilbert, IH (2003) Antiplasmodial activity of a series of 1,3,5-triazine-substituted polyamines. Journal of Antimicrobial Chemotherapy, 52(2), pp. 290-293. (doi: 10.1093/jac/dkg307)

Matovu, E. et al. (2003) Mechanisms of arsenical and diamidine uptake and resistance in Trypanosoma brucei. Eukaryotic Cell, 2(5), pp. 1003-1008. (doi: 10.1128/EC.2.5.1003-1008.2003)

Maugeri, DA, Cazzulo, JJ, Burchmore, RJS ORCID: https://orcid.org/0000-0003-1663-9004, Barrett, MP ORCID: https://orcid.org/0000-0001-9447-3519 and Ogbunude, POJ (2003) Pentose phosphate metabolism in Leishmania mexicana. Molecular and Biochemical Parasitology, 130(2), pp. 117-125. (doi: 10.1016/S0166-6851(03)00173-7)

Stich, A, Barrett, MP ORCID: https://orcid.org/0000-0001-9447-3519 and Krishna, S (2003) Waking up to sleeping sickness. Trends in Parasitology, 19(5), pp. 195-197. (doi: 10.1016/S1471-4922(03)00055-2)

2002

Leslie, G., Barrett, M. ORCID: https://orcid.org/0000-0001-9447-3519 and Burchmore, R. ORCID: https://orcid.org/0000-0003-1663-9004 (2002) Leishmania mexicana: promastigotes migrate through osmotic gradients. Experimental Parasitology, 102(2), pp. 117-120. (doi: 10.1016/S0014-4894(03)00031-6)

Barrett, M ORCID: https://orcid.org/0000-0001-9447-3519 (2002) Perspectives for new drugs against trypanosomiasis and leishmaniasis. Current Topics in Medicinal Chemistry, 2(5), pp. 471-482. (doi: 10.2174/1568026024607427)

Basselin, M, Denise, H, Coombs, GH and Barrett, MP ORCID: https://orcid.org/0000-0001-9447-3519 (2002) Resistance to pentamidine in Leishmania mexicana involves exclusion of the drug from the mitochondrion. Antimicrobial Agents and Chemotherapy, 46(12), pp. 3731-3738. (doi: 10.1128/AAC.46.12.3731-3788.2002)

Burchmore, RJS ORCID: https://orcid.org/0000-0003-1663-9004, Ogbunude, POJ, Enanga, B and Barrett, MP ORCID: https://orcid.org/0000-0001-9447-3519 (2002) Chemotherapy of human African trypanosomiasis. Current Pharmaceutical Design, 8(4), pp. 257-267. (doi: 10.2174/1381612023396159)

Enanga, B, Burchmore, RJS ORCID: https://orcid.org/0000-0003-1663-9004, Stewart, ML and Barrett, MP ORCID: https://orcid.org/0000-0001-9447-3519 (2002) Sleeping sickness and the brain. Cellular and Molecular Life Sciences, 59(5), pp. 845-858. (doi: 10.1007/s00018-002-8472-0)

Greenblatt, CL, Schnur, LF, Bar-Gal, GK, Ermolaev, H, Peleg, N and Barrett, MP ORCID: https://orcid.org/0000-0001-9447-3519 (2002) Polymorphism among alleles of the 6-Phosphogluconate dehydrogenase gene from Leishmania major and Leishmania tropica. Molecular and Biochemical Parasitology, 125(1-2), pp. 185-188. (doi: 10.1016/S0166-6851(02)00213-X)

Janssen, CS, Barrett, MP ORCID: https://orcid.org/0000-0001-9447-3519, Turner, CMR and Phillips, RS (2002) A large gene family for putative variant antigens shared by human and rodent malaria parasites. Proceedings of the Royal Society of London Series B: Biological Sciences, 269(1800), pp. 431-436. (doi: 10.1098/rspb.2001.1903)

2001

Bertelli, M., El-Bastawissy, E., Knaggs, M.H., Barrett, M.P. ORCID: https://orcid.org/0000-0001-9447-3519, Hanau, S. and Gilbert, I.H. (2001) Selective inhibition of 6-phosphogluconate dehydrogenase from Trypanosoma brucei. Journal of Computer-Aided Molecular Design, 15(5), pp. 465-475. (doi: 10.1023/A:1011196508214)

Burchmore, RJS ORCID: https://orcid.org/0000-0003-1663-9004 and Barrett, MP ORCID: https://orcid.org/0000-0001-9447-3519 (2001) Life in vacuoles - nutrient acquisition by Leishmania amastigotes. International Journal for Parasitology, 31(12), pp. 1311-1320. (doi: 10.1016/S0020-7519(01)00259-4)

Denise, H. and Barrett, M.P. ORCID: https://orcid.org/0000-0001-9447-3519 (2001) Uptake and mode of action of drugs used against sleeping sickness. Biochemical Pharmacology, 61(1), pp. 1-5. (doi: 10.1016/S0006-2952(00)00477-9)

Janssen, CS, Barrett, MP ORCID: https://orcid.org/0000-0001-9447-3519, Lawson, D, Quail, MA, Harris, D, Bowman, S, Phillips, RS and Turner, CMR (2001) Gene discovery in Plasmodium chabaudi by genome survey sequencing. Molecular and Biochemical Parasitology, 113(2), pp. 251-260. (doi: 10.1016/S0166-6851(01)00224-9)

Klenke, B, Stewart, M, Barrett, MP ORCID: https://orcid.org/0000-0001-9447-3519, Brun, R and Gilbert, IH (2001) Synthesis and biological evaluation of s-triazine substituted polyamines as potential new anti-trypanosomal drugs. Journal of Medicinal Chemistry, 44(21), pp. 3440-3452. (doi: 10.1021/jm010854+)

2000

De Koning, H.P. ORCID: https://orcid.org/0000-0002-9963-1827, MacLeod, A. ORCID: https://orcid.org/0000-0002-0150-5049, Barrett, M.P. ORCID: https://orcid.org/0000-0001-9447-3519, Cover, B. and Jarvis, S.M. (2000) Further evidence for a link between melarsoprol resistance and P2 transporter function in African trypanosomes. Molecular and Biochemical Parasitology, 106(1), pp. 181-185. (doi: 10.1016/S0166-6851(99)00206-6)

1999

Carter, N.S., Barrett, M.P. ORCID: https://orcid.org/0000-0001-9447-3519 and De Koning, H.P. ORCID: https://orcid.org/0000-0002-9963-1827 (1999) A drug resistance determinant in trypanosoma brucei. Trends in Microbiology, 7(12), pp. 469-471. (doi: 10.1016/S0966-842X(99)01643-1)

Tetaud, Emmanuel, Hanau, Stefania, Wekks, Jeremy M., Le Page, Richard W.F., Adams, Margaret J., Arkison, Scott ORCID: https://orcid.org/0000-0001-9471-4239 and Barrett, Michael P. ORCID: https://orcid.org/0000-0001-9447-3519 (1999) 6-phosphogluconate dehydrogenase from Lactococcus lactis: a role for arginine residues in binding substrate and coenzyme. Biochemical Journal, 338(1), pp. 55-60. (doi: 10.1042/bj3380055) (PMID:9931298) (PMCID:PMC1220024)

1998

Tetaud, E., Hall, D.R., Gourley, D.G., Leonard, G.A., Arkison, S. ORCID: https://orcid.org/0000-0001-9471-4239, Barrett, M.P. ORCID: https://orcid.org/0000-0001-9447-3519 and Hunter, W.N. (1998) Crystallization and preliminary X-ray diffraction studies of 6-phosphogluconate dehydrogenase from Lactococcus lactis. Acta Crystallographica Section D: Biological Crystallography, 54(6.2), pp. 1422-1424. (doi: 10.1107/s0907444998004909) (PMID:10089526)

1997

Barrett, Michael P. ORCID: https://orcid.org/0000-0001-9447-3519, MacLeod, Annette ORCID: https://orcid.org/0000-0002-0150-5049, Tovar, Jorge, Sweetman, Justin P., Tait, Andrew, Le Page, Richard W.F. and Melville, Sara E. (1997) A single locus minisatellite sequence which distinguishes between Trypanosoma brucei isolates. Molecular and Biochemical Parasitology, 86(1), pp. 95-99. (doi: 10.1016/S0166-6851(97)02832-6) (PMID:9178271)