TY  - JOUR
N2  - This paper studies human gallbladder (GB) smooth muscle contractions. A two-state cross-bridge model was used to estimate the apparent attachment and detachment rate constants, as well as increased Ca(2+) concentration from the peak active stress during the isometric contraction. The active stress was computed from a mechanical model based entirely on non-invasive routine ultrasound scans. In the two-state cross-bridge model, the two apparent rate constants, representing the total attached/detached cross-bridges, respectively, were estimated using active stress prediction for 51 subjects undergoing cholecystokinin-provocation test, together with estimates from the four-state cross-bridge model for a swine carotid, bovine tracheal and guinea pig GB smooth muscles. The study suggests that the apparent rate constants should be patient-specific, i.e. patients with a lower stress level are characterized by smaller apparent rate constants. In other words, the diseased GB may need to develop fast cycling cross-bridges to compensate in the emptying process. This is a first step towards more quantitative and non-invasive measures of GB pain, and may provide useful insight in understanding GB motility and developing effective drug treatments.
AV  - none
Y1  - 2011/11/01/
VL  - 32
SN  - 0142-4319
PB  - Springer Verlag
TI  - Cross-bridge apparent rate constants of human gallbladder smooth muscle
SP  - 209
EP  - 220
IS  - 3
JF  - Journal of Muscle Research and Cell Motility
ID  - enlighten56490
UR  - http://dx.doi.org/10.1007/s10974-011-9260-y
A1  - Li, W.G.
A1  - Luo, X.Y.
A1  - Hill, N.A.
A1  - Ogden, R.W.
A1  - Tian, T.H.
A1  - Smythe, A.
A1  - Majeed, A.W.
A1  - Bird, N.
ER  -