RT Journal Article
SR 00
ID 10.1016/j.schres.2024.12.005
A1 Brunner, Gina
A1 Gajwani, Ruchika
A1 Gross, Joachim
A1 Gumley, Andrew
A1 Timmerman, Rosanne H.
A1 Taylor, Rebecca
A1 Krishnadas, Rajeev
A1 Lawrie, Stephen M.
A1 Schwannauer, Matthias
A1 Schultze-Lutter, Frauke
A1 Uhlhaas, Peter
A1 Fracasso, Alessio
T1 Choroid plexus morphology in schizophrenia and early-stage psychosis: a cross-sectional study
JF Schizophrenia Research
YR 2025
FD 2025-01
VO 275
SP 107
OP 114
AB Background:  The choroid plexus is an important structure within the ventricular system. Schizophrenia has been associated with morphological changes to the choroid plexus but the presence and extent of alterations at different illness stages is unclear.    Methods:  We examined choroid plexus volumes in participants at clinical high-risk for psychosis (N = 110), participants with first-episode psychosis (N = 37), participants with schizophrenia (N = 28), clinical (N = 38) and non-clinical controls (N = 75). Automated segmentation (Gaussian mixture model) was used to estimate choroid plexus volumes from T1 magnetic resonance (MR) images. We then conducted a linear model and Bayes factor analysis to investigate group differences. In addition, the relationship between choroid plexus volumes and clinical characteristics was assessed.    Results:  Schizophrenia patients were characterized by increased choroid plexus and ventricular volume while first-episode psychosis and clinical high-risk for psychosis participants showed no differences in choroid plexus volumes. However, choroid plexus volumes in schizophrenia patients did not significantly differ from controls when controlling for ventricular volume. Finally, choroid plexus volumes were not associated with clinical characteristics in the clinical high-risk group.    Conclusion:  Our findings suggest that morphological alterations are not specific to the choroid plexus in schizophrenia and early-stage psychosis. Previously reported choroid plexus abnormalities in schizophrenia patients could be explained by changes in ventricular volume.
NO The study was supported by the Medical Research Council (MR/L011689/1). This publication was supported by the University of Glasgow's Lord Kelvin/Adam Smith (LKAS) PhD Scholarship.
PB Elsevier
SN 0920-9964
LK https://eprints.gla.ac.uk/343467/