RT Journal Article
SR 00
ID 10.1093/schizbullopen/sgae029
A1 Haining, Kate
A1 Gajwani, Ruchika
A1 Gross, Joachim
A1 Gumley, Andrew I.
A1 Lawrie, Stephen M.
A1 Schultze-Lutter, Frauke
A1 Schwannauer, Matthias
A1 Uhlhaas, Peter J.
T1 Clinical and functional outcomes of community-recruited individuals at clinical high-risk for psychosis: results from the Youth Mental Health Risk and Resilience Study (YouR-Study)
JF Schizophrenia Bulletin Open
YR 2024
FD 2024-01
VO 5
IS 1
K1 Clinical high-risk, psychosis, early detection and intervention, web screening, longitudinal outcomes.
AB Clinical high-risk for psychosis (CHR-P) individuals are typically recruited from clinical services but the clinical and functional outcomes of community-recruited CHR-P individuals remain largely unclear. The Youth Mental Health Risk and Resilience Study (YouR-Study) obtained a community sample of CHR-P individuals through an online-screening approach and followed-up these individuals for a period of up to 3 years to determine transition rates, persistence of attenuated psychotic symptoms (APS) and functional outcomes. Baseline data were obtained from n = 144 CHR-P participants, n = 51 participants who met online cutoff criteria but not CHR-P criteria (CHR-Ns), and n = 58 healthy controls. Baseline assessments included clinical measures for assessing CHR-P status, including the Comprehensive Assessment of At-Risk Mental States (CAARMS) and the Schizophrenia Proneness Instrument, Adult version (SPI-A), as well as functioning and cognitive measures. CHR-P and CHR-N groups were followed-up. Results show that 12.1% of CHR-P individuals transitioned to psychosis over 3 years, with no transitions in the CHR-N group. Nearly 60% of CHR-P individuals experienced poor functional outcome (PFO) and over 40% experienced persistent APS. A combination of CAARMS/SPI-A criteria was associated with a higher likelihood of PFO, but not with transition to psychosis nor APS persistence. However, transition risk was generally higher among those meeting both CAARMS/SPI-A criteria (64.3%) vs CAARMS (28.6%) or SPI-A (7.1%) alone. In summary, community-recruited CHR-P individuals are characterized by similar clinical characteristics and longitudinal outcomes to those recruited from clinical services, emphasizing the need to widen the scope of early detection and intervention strategies.
NO This study was supported by project MR/L011689/1 from the Medical Research Council (MRC).
PB Oxford University Press
SN 2632-7899
LK https://eprints.gla.ac.uk/341059/