TY  - JOUR
KW  - Clinical high-risk
KW  -  psychosis
KW  -  early detection and intervention
KW  -  web screening
KW  -  longitudinal outcomes.
AV  - public
N2  - Clinical high-risk for psychosis (CHR-P) individuals are typically recruited from clinical services but the clinical and functional outcomes of community-recruited CHR-P individuals remain largely unclear. The Youth Mental Health Risk and Resilience Study (YouR-Study) obtained a community sample of CHR-P individuals through an online-screening approach and followed-up these individuals for a period of up to 3 years to determine transition rates, persistence of attenuated psychotic symptoms (APS) and functional outcomes. Baseline data were obtained from n?=?144 CHR-P participants, n?=?51 participants who met online cutoff criteria but not CHR-P criteria (CHR-Ns), and n?=?58 healthy controls. Baseline assessments included clinical measures for assessing CHR-P status, including the Comprehensive Assessment of At-Risk Mental States (CAARMS) and the Schizophrenia Proneness Instrument, Adult version (SPI-A), as well as functioning and cognitive measures. CHR-P and CHR-N groups were followed-up. Results show that 12.1% of CHR-P individuals transitioned to psychosis over 3 years, with no transitions in the CHR-N group. Nearly 60% of CHR-P individuals experienced poor functional outcome (PFO) and over 40% experienced persistent APS. A combination of CAARMS/SPI-A criteria was associated with a higher likelihood of PFO, but not with transition to psychosis nor APS persistence. However, transition risk was generally higher among those meeting both CAARMS/SPI-A criteria (64.3%) vs CAARMS (28.6%) or SPI-A (7.1%) alone. In summary, community-recruited CHR-P individuals are characterized by similar clinical characteristics and longitudinal outcomes to those recruited from clinical services, emphasizing the need to widen the scope of early detection and intervention strategies.
Y1  - 2024/01//
N1  - This study was supported by project MR/L011689/1 from the Medical Research Council (MRC).
VL  - 5
SN  - 2632-7899
IS  - 1
PB  - Oxford University Press
TI  - Clinical and functional outcomes of community-recruited individuals at clinical high-risk for psychosis: results from the Youth Mental Health Risk and Resilience Study (YouR-Study)
JF  - Schizophrenia Bulletin Open
A1  - Haining, Kate
A1  - Gajwani, Ruchika
A1  - Gross, Joachim
A1  - Gumley, Andrew I.
A1  - Lawrie, Stephen M.
A1  - Schultze-Lutter, Frauke
A1  - Schwannauer, Matthias
A1  - Uhlhaas, Peter J.
UR  - https://eprints.gla.ac.uk/341059/
ID  - enlighten341059
ER  -