RT Journal Article
SR 00
ID 10.1007/s11906-024-01317-0
A1 Zhou, Manshi
A1 Mary, Sheon
A1 Delles, Christian
A1 Padmanabhan, Sandosh
A1 Graham, Delyth
A1 McBride, Martin W.
A1 Dominiczak, Anna
T1 Insights into uromodulin and blood pressure
JF Current Hypertension Reports
YR 2024
FD 2024-09-11
K1 Uromodulin, blood pressure regulation, hypertension, Mendelian randomisation, ethnic and sex diferences, biomarker
AB Purpose of Review  We review the role of uromodulin, a protein exclusively expressed in the kidney, in blood pressure regulation and hypertension.    Recent Findings  The last few years have seen a shift of focus from genetic association to mendelian randomisation and uromodulin-salt interaction studies, thus confirming the causal role of uromodulin in blood pressure regulation and hypertension. This work has been complemented by phenome-wide association studies in a wider range of ethnicities. Important recent molecular work elucidated uromodulin trafficking and secretion and provided more insights into the pathophysiological roles of circulating and urinary uromodulin.    Summary  Uromodulin has a causal role in blood pressure regulation and hypertension. Recent studies show utility of the uromodulin as a biomarker and a possible precision medicine application based on genetically determined differential responses to loop diuretics.
PB Springer
SN 1522-6417
LK https://eprints.gla.ac.uk/334611/