TY  - JOUR
ID  - enlighten334611
UR  - https://eprints.gla.ac.uk/334611/
A1  - Zhou, Manshi
A1  - Mary, Sheon
A1  - Delles, Christian
A1  - Padmanabhan, Sandosh
A1  - Graham, Delyth
A1  - McBride, Martin W.
A1  - Dominiczak, Anna
Y1  - 2024/09/11/
N2  - Purpose of Review
We review the role of uromodulin, a protein exclusively expressed in the kidney, in blood pressure regulation and hypertension.

Recent Findings
The last few years have seen a shift of focus from genetic association to mendelian randomisation and uromodulin-salt interaction studies, thus confirming the causal role of uromodulin in blood pressure regulation and hypertension. This work has been complemented by phenome-wide association studies in a wider range of ethnicities. Important recent molecular work elucidated uromodulin trafficking and secretion and provided more insights into the pathophysiological roles of circulating and urinary uromodulin.

Summary
Uromodulin has a causal role in blood pressure regulation and hypertension. Recent studies show utility of the uromodulin as a biomarker and a possible precision medicine application based on genetically determined differential responses to loop diuretics.
PB  - Springer
JF  - Current Hypertension Reports
KW  - Uromodulin
KW  -  blood pressure regulation
KW  -  hypertension
KW  -  Mendelian randomisation
KW  -  ethnic and sex diferences
KW  -  biomarker
SN  - 1522-6417
TI  - Insights into uromodulin and blood pressure
AV  - public
ER  -