RT Journal Article
SR 00
ID 10.1016/j.bpsc.2023.09.006
A1 Dheerendra, Pradeep
A1 Grent-'t-Jong, Tineke
A1 Gajwani, Ruchika
A1 Gross, Joachim
A1 Gumley, Andrew I.
A1 Krishnadas, Rajeev
A1 Lawrie, Stephen M.
A1 Schwannauer, Matthias
A1 Schultze-Lutter, Frauke
A1 Uhlhaas, Peter J.
T1 Intact mismatch negativity responses in clinical high-risk for psychosis and first-episode psychosis: evidence from source-reconstructed event-related fields and time-frequency data
JF Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
YR 2024
FD 2024-01
VO 9
IS 1
SP 121
OP 131
AB Background:  To examine whether Mismatch Negativity (MMN) Responses are impaired in participants at clinical high-risk for psychosis (CHR-P) and first episode psychosis (FEP) patients and whether MMN-deficits predict clinical outcomes in CHR-Ps.    Methods:  Magnetoencephalography (MEG) data were collected during a duration-deviant MMN-paradigm for a group of 116 CHR-P participants, 33 FEP patients, (15 antipsychotic-naïve), a psychosis-risk-negative group (CHR-N: n=38) with substance abuse and affective disorder and 49 healthy controls (HC). Analysis of group differences of source-reconstructed event-related fields as well as time-frequency and inter-trial-phase-coherence (ITPC) focused on bilateral Heschl’s gyri and superior temporal gyri.    Results:  Significant MMNm responses were found across participants in bilateral Heschl’s gyrus and superior temporal gyri. However, MMN-amplitude as well as time-frequency and ITPC-responses were intact in CHR-P and FEP-patients relative to HC. Furthermore, MMN-deficits were not related to persistent attenuated psychotic symptoms nor transitions to psychosis in CHR-Ps.    Conclusions:  Our data suggest that MMNm responses in MEG-data are not impaired in early-stage psychosis and may not predict clinical outcomes in CHR-P participants.
PB Elsevier
SN 2451-9022
LK https://eprints.gla.ac.uk/307596/