TY  - JOUR
ID  - enlighten282572
UR  - https://eprints.gla.ac.uk/282572/
IS  - 17
A1  - Salah, Husam M.
A1  - Goldberg, Lee R.
A1  - Molinger, Jeroen
A1  - Felker, G. Michael
A1  - Applefeld, Willard
A1  - Rassaf, Tienush
A1  - Tedford, Ryan J.
A1  - Mirro, Michael
A1  - Cleland, John G.F.
A1  - Fudim, Marat
Y1  - 2022/10/25/
N2  - In addition to the diaphragm?s role as the primary respiratory muscle, it also plays an under-recognized role in cardiac function. It serves as a pump facilitating venous and lymph return, modulating left ventricular afterload hemodynamics and pericardial pressures, as well as regulating autonomic tone. Heart failure (HF) is associated with diaphragmatic changes (ie, muscle fiber atrophy and weakness, increased ratio of type I to type II muscle fibers, and altered muscle metaboreflex) that lead to diaphragmatic dysfunction with subsequent symptomatic manifestations of HF. Herein, it is proposed that targeting the diaphragm in patients with HF via inspiratory muscle training or device-based stimulation can provide a novel treatment pathway for HF. Reviewed are several potential mechanisms through which therapies targeting the diaphragm can be beneficial in HF (ie, improving preload reserve, atrial and ventricular synchrony, and metaboreflex activity; reducing pericardial restraint; and restoring diaphragm strength).
PB  - Elsevier
JF  - Journal of the American College of Cardiology
VL  - 80
SN  - 0735-1097
TI  - Diaphragmatic function in cardiovascular disease: JACC review topic of the week
SP  - 1647
AV  - public
EP  - 1659
ER  -