TY  - JOUR
ID  - enlighten282033
UR  - https://eprints.gla.ac.uk/282033/
A1  - Gulati, Martha
A1  - Khan, Najah
A1  - George, Maria
A1  - Berry, Colin
A1  - Chieffo, Alaide
A1  - Camici, Paolo G.
A1  - Crea, Filippo
A1  - Kaski, Juan-Carlos
A1  - Marzilli, Mario
A1  - Merz, C. Noel Bairey
Y1  - 2023/01/15/
N2  - Background: There is limited information available regarding evidence of ischemia with no obstructive coronary arteries (INOCA) and quality of life.

Purpose: To determine associations between INOCA and self-reported physical, social, and mental health.

Methods: We conducted a survey of all members (n = 1579) of the INOCA International patient support group. Current self-reported diagnosis and health measures were collected. Functional capacity was retrospectively estimated using the Duke Activity Status Index (DASI), assessing levels of activities performed prior and after symptom onset.

Results: A total of 297 (20.8% response rate, 91% women) reported symptoms of chest pain, pressure, or discomfort in 92.9%. Overall, 34.4% were living with symptoms for ?3 years before an INOCA diagnosis, and 77.8% were told their symptoms were not cardiac. Estimated functional capacity was higher prior to compared to after symptom onset (8.6 � 1.8 METs vs 5.6 � 1.8 METs; P < 0.0001). Most respondents reported an adverse impact of symptoms on their home life (80.5%), social life (80.1%), mental health (70.4%), outlook on life (69.7%), sex life (55.9%), and their partner/spouse relationship (53.9%), while approximately three-quarters reduced their work hours or stopped work completely, 47.5% retired early, and 38.4% applied for disability.

Conclusions: INOCA symptoms are associated with adverse physical, mental and social health quality of life. Increased patient awareness, physician recognition and diagnosis, and clinical trials are needed to develop evidence-based guidelines for this increasingly recognized cardiovascular disorder.
PB  - Elsevier
JF  - International Journal of Cardiology
VL  - 371
SN  - 0167-5273
TI  - Ischemia with no obstructive coronary artery disease (INOCA): a patient self-report quality of life survey from INOCA international
SP  - 28
AV  - public
EP  - 39
ER  -