TY  - JOUR
AV  - public
N2  - Breakthroughs in our understanding of the complex interplay between cellular nanoenvironment and biomolecular signalling pathways are facilitating development of targeted osteogenic platforms. As critical biomolecules for osteogenesis, growth factors stimulate osteogenesis by activating key genes and transcription factors. The first half of this review presents emerging interconnectedness and recent discoveries of osteogenic signalling pathways initiating from growth factors for example, bone morphogenetic protein 2 (BMP-2). To complement this, the second half of review proposes a number of strategies to induce osteogenesis which include metallic, organic implants, nanotopological environments as well as growth factor immobilization techniques. The drawbacks of traditional osteogenic implants and how these have been overcome by biomedical engineers in the recent years without producing side-effects have also been summarized.
Y1  - 2022/02//
SN  - 0958-1669
VL  - 73
PB  - Elsevier
TI  - An ossifying landscape: materials and growth factor strategies for osteogenic signalling and bone regeneration
SP  - 355
EP  - 363
JF  - Current Opinion in Biotechnology
UR  - https://eprints.gla.ac.uk/258831/
ID  - enlighten258831
A1  - Dhawan, Udesh
A1  - Jaffery, Hussain
A1  - Salmeron-Sanchez, Manuel
A1  - Dalby, Matthew J.
ER  -