eprintid: 243103 rev_number: 44 eprint_status: archive userid: 45630 dir: disk0/00/24/31/03 datestamp: 2021-06-02 12:57:41 lastmod: 2023-08-28 13:55:42 status_changed: 2021-06-02 12:57:41 type: article metadata_visibility: show creators_name: Martin, Tamara P. creators_name: MacDonald, Eilidh A. creators_name: Elbassioni, Ali Ali creators_name: Zaeri, Ali Abdullah I. creators_name: O'Toole, Dylan creators_name: Nicklin, Stuart A. creators_name: Gray, Gillian A. creators_name: Loughrey, Christopher M. creators_orcid: 0000-0002-2509-2613 creators_orcid: 0000-0002-7771-754X creators_orcid: 0000-0002-9691-6210 creators_orcid: 0000-0003-1297-9159 title: Pre-clinical models of myocardial infarction: from mechanism to translation ispublished: pub divisions: 25200000 divisions: 20300000 full_text_status: public abstract: Approximately 7 million people are affected by acute myocardial infarction (MI) each year, and despite significant therapeutic and diagnostic advancements, MI remains a leading cause of mortality worldwide. Pre-clinical animal models have significantly advanced our understanding of MI and enable the development of therapeutic strategies to combat this debilitating disease. Notably, some drugs currently used to treat MI and heart failure (HF) in patients had initially been studied in pre-clinical animal models. Despite this, pre-clinical models are limited in their ability to fully recapitulate the complexity of MI in humans. The pre-clinical model must be carefully selected to maximise the translational potential of experimental findings. This review describes current experimental models of MI and considers how they have been used to understand drug mechanisms of action (MOA) and support translational medicine development. date: 2022-03 date_type: published publication: British Journal of Pharmacology volume: 179 number: 5 publisher: Wiley pagerange: 770-791 id_number: 10.1111/bph.15595 refereed: TRUE issn: 0007-1188 copyright_holders: Copyright © 2021 The Authors prior: First published in British Journal of Pharmacology 179(5): 770-791 repro: Reproduced under a Creative Commons License uniqueid: glaseprints:2022-243103 issn_online: 1476-5381 funding_project_code: 308798 funding_project_code: 301985 funding_project_code: 300489 funding_project_code: 303944 funding_project_name: Targeting RUNX to Attenuate Adverse Cardiac Remodelling funding_project_name: Investigating the Therapeutic Potential of Runx1 for Myocardial Infarction funding_project_name: Cardiac gene therapy with angiotensin-(1-9): dissecting the underlying mechanism for preservation of cardiac function post-myocardial infarction funding_project_name: BHF Centre of Excellence funding_investigator_name: Christopher Loughrey funding_investigator_name: Christopher Loughrey funding_investigator_name: Stuart Nicklin funding_investigator_name: Rhian Touyz funding_funder_name: British Heart Foundation (BHF) funding_funder_name: British Heart Foundation (BHF) funding_funder_name: British Heart Foundation (BHF) funding_funder_name: British Heart Foundation (BHF) funding_funder_code: RG/20/6/35095 funding_funder_code: PG/18/9/33548 funding_funder_code: PG/17/17/32877 funding_funder_code: RE/18/6/34217 funding_investigator_dept: Vets - Veterinary Pathology, Public Health & Disease Investigation funding_investigator_dept: CAMS - Cardiovascular Science funding_investigator_dept: CAMS - Cardiovascular Science funding_investigator_dept: CAMS - Cardiovascular Science pubmed_id: 34131903 euro_pubmed_id: 34131903 legacy_divisions: L20300000 hoa_compliant: 9023 hoa_emb_len: 0 hoa_ref_pan: AB hoa_date_acc: 2021-05-28 hoa_date_pub: 2021-06-15 hoa_date_foa: 2021-08-17 hoa_version_fcd: AM hoa_exclude: FALSE hoa_gold: TRUE oa_research_materials_ack: Yes-no-data rioxx2_license_ref_input_license_ref: http://creativecommons.org/licenses/by/4.0/ rioxx2_license_ref_input_start_date: 2021-08-11 citation: Martin, T. P. , MacDonald, E. A. , Elbassioni, A. A. , Zaeri, A. A. I. , O'Toole, D. , Nicklin, S. A. , Gray, G. A. and Loughrey, C. M. (2022) Pre-clinical models of myocardial infarction: from mechanism to translation. British Journal of Pharmacology , 179(5), pp. 770-791. (doi: 10.1111/bph.15595 ) (PMID:34131903) document_url: https://eprints.gla.ac.uk/243103/1/243103.pdf