RT Journal Article SR 00 ID 10.3389/frym.2021.639681 A1 Farthing, Andrew G. A1 Howell, Jessie A1 Baillie, J. Kenneth A1 Forde, Taya A1 Garrett, Alice A1 Goodyear, Carl S. A1 Gracie, Jennifer A1 Graham, Colin A1 Hammarton, Tansy C. A1 Murphy, Michael E. A1 Peveler, William J. A1 Pybus, Simon A1 Sajib, Mohammad Saiful Islam A1 Thomson, Gill A1 Jimenez, Melanie T1 Sepsis: when a simple infection becomes deadly JF Frontiers for Young Minds YR 2021 FD 2021 VO 9 AB The immune system plays a crucial role in maintaining a healthy body by working around the clock to recognize and respond to infection. Inflammation is part of the immune system’s protective response to an infection. The inflammatory response is incredibly powerful, so much so that it can damage the body’s cells if it is not tightly controlled. Sometimes, inflammation affects the whole body—this is called sepsis. The powerful and complex mechanisms in place to wipe out the infection can cause serious damage to healthy cells and tissues. Uncontrolled inflammation can cause irreversible damage to the body’s organs, such as the kidneys, eventually causing organs to shut down. If sepsis is not treated rapidly, it can lead to death. In this article, we describe the symptoms and diagnosis of sepsis and some of the current research being performed to better understand this dangerous process. PB Frontiers Media SN 2296-6846 LK https://eprints.gla.ac.uk/242310/