TY  - JOUR
ID  - enlighten236478
UR  - https://eprints.gla.ac.uk/236478/
IS  - 10
A1  - Lees, Jennifer S.
A1  - Rankin, Alastair J.
A1  - Gillis, Keith A.
A1  - Zhu, Luke Y.
A1  - Mangion, Kenneth
A1  - Rutherford, Elaine
A1  - Roditi, Giles H.
A1  - Witham, Miles D.
A1  - Chantler, Donna
A1  - Panarelli, Maurizio
A1  - Jardine, Alan G.
A1  - Mark, Patrick B.
N2  - Premature cardiovascular disease and death with a functioning graft are leading causes of death and graft loss respectively in kidney transplant recipients (KTR). Vascular stiffness and calcification are markers of cardiovascular disease that are prevalent in KTR and associated with subclinical vitamin K deficiency. We performed a single?centre, phase II, parallel?group, randomised, double?blind, placebo?controlled trial (ISRCTN22012044) to test whether vitamin K supplementation reduced vascular stiffness (MRI?based aortic distensibility) or calcification (coronary artery calcium score on computed tomography) in KTR over 1 year of treatment. The primary outcome was between?group difference in vascular stiffness (ascending aortic distensibility). KTR were recruited between September 2017 and June 2018, and randomised 1:1 to vitamin K (Menadiol diphosphate 5mg; n=45) or placebo (n=45) thrice?weekly. Baseline demographics, clinical history and immunosuppression regimens were similar between groups. There was no impact of vitamin K on vascular stiffness (treatment effect ?0.23 (95% CI ?0.75 to 0.29) x10?3 mmHg?1; p=0.377), vascular calcification (treatment effect ?141 (95% CI ?320 to 38) units; p=0.124), nor any other outcome measure. In this heterogeneous cohort of prevalent KTR, vitamin K supplementation did not reduce vascular stiffness or calcification over 1 year. Improving vascular health in KTR is likely to require a multifaceted approach.
VL  - 21
TI  - The ViKTORIES trial: a randomised, double-blind, placebo-controlled trial of vitamin K supplementation to improve vascular health in kidney transplant recipients
AV  - public
EP  - 3368
N1  - We would like to thank the kidney research nurses, clinical trials pharmacy and ViKTORIES participants. ViKTORIES was an investigator-led clinical trial that was funded by Kidney Research UK (TF_013_20161225) and Darlinda?s Charity for Renal Research. J.S.L. was personally funded by a Kidney Research UK Training Fellowship (TF_013_20161225) and a British Heart Foundation Centre of Excellence Award (RE/13/5/30177). J.S.L. and E.R. are
currently funded by Chief Scientist Office (Scotland) Postdoctoral Lectureships. M.D.W. acknowledges support from the NIHR Newcastle Biomedical Research Centre.
Y1  - 2021/10//
PB  - Wiley
JF  - American Journal of Transplantation
SN  - 1600-6135
SP  - 3356
ER  -