TY  - JOUR
ID  - enlighten221335
UR  - https://eprints.gla.ac.uk/221335/
IS  - 4
A1  - Brown, Oliver
A1  - Costanzo, Pierluigi
A1  - Clark, Andrew L.
A1  - Condorelli, Gianluigi
A1  - Cleland, John G.F.
A1  - Sathyapalan, Thozhukat
A1  - Hepburn, David
A1  - Kilpatrick, Eric S.
A1  - Atkin, Stephen L.
Y1  - 2020/12//
N2  - Objective: 

This study aims to evaluate the relationship between a single measurement at baseline of body mass index (BMI), glycated hemoglobin (HbA1c) and subsequent clinical outcomes in patients with type 2 diabetes mellitus (T2DM).
Method:

Patients with T2DM were recruited from an outpatient diabetes clinic in a single large teaching hospital in Kingston upon Hull, UK. At baseline, demographics and HbA1c were recorded. Patients were categorized by BMI: normal weight (18.5?24.9?kg/m2), overweight (25?29.9?kg/m2), and obese (>30?kg/m2). Multivariable Cox regression models that included demographic, risk factors, and comorbidities were separately constructed for all-cause, cardiovascular, cancer and sepsis-related mortality, using four groups of HbA1c (<6%, 6.0?6.9%, 7.0?7.9%, and >8%).
Results:

In total, 6220 patients with T2DM (median age 62?years, 54% male) were followed for a median of 10.6?years. HbA1c levels >8.0% were associated with increased risk of all-cause mortality and cardiovascular death. However, this increased risk was not consistent across the weight categories and reached statistical significance only in overweight patients (BMI 25?29.9?kg/m2).
Conclusions:

In a large cohort of patients with T2DM elevated HbA1c levels at baseline did not consistently predict increased risk of all-cause and cardiovascular mortality across the different BMI categories.
PB  - Lippincott, Williams and Wilkins
JF  - Cardiovascular Endocrinology and Metabolism
VL  - 9
SN  - 2574-0954
TI  - Relationship between a single measurement at baseline of body mass index, glycated hemoglobin, and the risk of mortality and cardiovascular morbidity in type 2 diabetes mellitus
SP  - 177
AV  - public
EP  - 182
ER  -