RT Journal Article
SR 00
ID 10.1155/2011/369648
A1 Castelló, Alfredo
A1 Álvarez, Enrique
A1 Carrasco, Luis
T1 The multifaceted poliovirus 2A protease: regulation of gene expression by picornavirus proteases
JF Journal of Biomedicine and Biotechnology
YR 2011
FD 2011
VO 2011
AB After entry into animal cells, most viruses hijack essential components involved in gene expression. This is the case of poliovirus, which abrogates cellular translation soon after virus internalization. Abrogation is achieved by cleavage of both eIF4GI and eIF4GII by the viral protease 2A. Apart from the interference of poliovirus with cellular protein synthesis, other gene expression steps such as RNA and protein trafficking between nucleus and cytoplasm are also altered. Poliovirus 2Apro is capable of hydrolyzing components of the nuclear pore, thus preventing an efficient antiviral response by the host cell. Here, we compare in detail poliovirus 2Apro with other viral proteins (from picornaviruses and unrelated families) as regard to their activity on key host factors that control gene expression. It is possible that future analyses to determine the cellular proteins targeted by 2Apro will uncover other cellular functions ablated by poliovirus infection. Further understanding of the cellular proteins hydrolyzed by 2Apro will add further insight into the molecular mechanism by which poliovirus and other viruses interact with the host cell.
PB Hindawi
SN 1110-7243
LK https://eprints.gla.ac.uk/219038/