RT Journal Article
SR 00
ID 10.1002/ccd.28373
A1 Ford, Thomas J.
A1 Khan, Adnan
A1 Docherty, Kiernan F.
A1 Jackson, Alice
A1 Morrow, Andrew
A1 Sidik, Novalia
A1 Rocchiccioli, Paul
A1 Good, Richard
A1 Eteiba, Hany
A1 Watkins, Stuart
A1 Shaukat, Aadil
A1 Lindsay, Mitchell
A1 Robertson, Keith
A1 Petrie, Mark
A1 Berry, Colin
A1 Oldroyd, Keith
A1 McEntegart, Margaret
T1 Sex differences in procedural and clinical outcomes following rotational atherectomy
JF Catheterization and Cardiovascular Interventions
YR 2020
FD 2020-02
VO 95
IS 2
SP 232
OP 241
AB Aim:    Evaluate sex differences in procedural net adverse clinical events and long‐term outcomes following rotational atherectomy (RA).  Methods and Results:    From August 2010 to 2016, 765 consecutive patients undergoing RA PCI were followed up for a median of 4.7 years. 285 (37%) of subjects were female. Women were older (mean 76 years vs. 72 years; p < .001) and had more urgent procedures (64.6 vs. 47.3%; p < .001). Females received fewer radial procedures (75.1 vs. 85.1%; p < .001) and less intravascular imaging guidance (16.8 vs. 25.0%; p = .008). After propensity score adjustment, the primary endpoint of net adverse cardiac events (net adverse clinical events: all‐cause death, myocardial infarction, stroke, target vessel revascularization plus any procedural complication) occurred more often in female patients (15.1 vs. 9.0%; adjusted OR 1.81 95% CI 1.04–3.13; p = .037). This was driven by an increased risk of procedural complications rather than procedural major adverse cardiac events (MACE). Specifically, women were more likely to experience coronary dissection (4.6 vs. 1.3%; p = .008), cardiac tamponade (2.1 vs. 0.4%; p = .046) and significant bleeding (BARC ≥2: 5.3 vs. 2.3). Despite this, overall MACE‐free survival was similar between males and females (adjusted HR 1.03; 95% CI 0.80–1.34; p = .81). Procedural complications during RA were associated with almost double the incidence of MACE at long‐term follow‐up (HR 1.92; 95% CI 1.34–2.77; p < .001).  Conclusion:    Women may be at greater risk of procedural complications following rotational atherectomy. These include periprocedural bleeding episodes and coronary perforation leading to cardiac tamponade. Despite this, the adjusted overall long‐term survival free of major adverse cardiac events was similar between males and females.
PB Wiley
SN 1522-1946
LK https://eprints.gla.ac.uk/189184/