eprintid: 186839 rev_number: 10 eprint_status: archive userid: 37347 dir: disk0/00/18/68/39 datestamp: 2019-12-12 13:30:11 lastmod: 2020-05-28 22:02:47 status_changed: 2019-12-12 13:30:11 type: article metadata_visibility: show sword_depositor: 37347 creators_name: Freeman, Suzanne C. creators_name: Kerby, Clareece R. creators_name: Patel, Amit creators_name: Cooper, Nicola J. creators_name: Quinn, Terry creators_name: Sutton, Alex J. creators_orcid: 0000-0003-1401-0181 title: Development of an interactive web-based tool to conduct and interrogate meta-analysis of diagnostic test accuracy studies: MetaDTA ispublished: pub divisions: 25200000 full_text_status: public keywords: Application, meta-analysis, diagnostic test accuracy. note: The Complex Reviews Support Unit is funded by the National Institute for Health Research (project number 14/178/29). AP is funded by a National Institute for Health Research Systematic Review Fellowship. abstract: BACKGROUND:Recommended statistical methods for meta-analysis of diagnostic test accuracy studies require relatively complex bivariate statistical models which can be a barrier for non-statisticians. A further barrier exists in the software options available for fitting such models. Software accessible to non-statisticians, such as RevMan, does not support the fitting of bivariate models thus users must seek statistical support to use R, Stata or SAS. Recent advances in web technologies make analysis tool creation much simpler than previously. As well as accessibility, online tools can allow tailored interactivity not found in other packages allowing multiple perspectives of data to be displayed and information to be tailored to the user's preference from a simple interface. We set out to: (i) Develop a freely available web-based "point and click" interactive tool which allows users to input their DTA study data and conduct meta-analyses for DTA reviews, including sensitivity analyses. (ii) Illustrate the features and benefits of the interactive application using an existing DTA meta-analysis for detecting dementia. METHODS:To create our online freely available interactive application we used the existing R packages lme4 and Shiny to analyse the data and create an interactive user interface respectively. RESULTS:MetaDTA, an interactive online application was created for conducting meta-analysis of DTA studies. The user interface was designed to be easy to navigate having different tabs for different functions. Features include the ability for users to enter their own data, customise plots, incorporate quality assessment results and quickly conduct sensitivity analyses. All plots produced can be exported as either .png or .pdf files to be included in report documents. All tables can be exported as .csv files. CONCLUSIONS:MetaDTA, is a freely available interactive online application which meta-analyses DTA studies, plots the summary ROC curve, incorporates quality assessment results and allows for sensitivity analyses to be conducted in a timely manner. Due to the rich feature-set and user-friendliness of the software it should appeal to a wide audience including those without specialist statistical knowledge. We encourage others to create similar applications for specialist analysis methods to encourage broader uptake which in-turn could improve research quality. date: 2019-04-18 date_type: published publication: BMC Medical Research Methodology volume: 19 number: 1 publisher: BioMed Central id_number: 10.1186/s12874-019-0724-x refereed: TRUE issn: 1471-2288 funders: ** Funder: National Institute for Health Research; Grant(s): 14/178/29 copyright_holders: Copyright © 2019 The Authors prior: First published in BMC Medical Research Methodology 19(1):81 repro: Reproduced under a Creative Commons License uniqueid: glaseprints:2019-186839 issn_online: 1471-2288 article_number: 81 pubmed_id: 30999861 euro_pubmed_id: 30999861 pmcid: PMC6471890 item_issues2_id: duplicate_doi_185639 item_issues2_id: duplicate_doi_185771 item_issues2_id: duplicate_title_185639 item_issues2_id: duplicate_title_185771 item_issues2_type: duplicate_doi item_issues2_type: duplicate_doi item_issues2_type: duplicate_title item_issues2_type: duplicate_title item_issues2_description: Duplicate DOI to Development of an interactive web-based tool to conduct and interrogate meta-analysis of diagnostic test accuracy studies: MetaDTA.
User Workarea, Publications Router - [ Manage ] [ Compare & Merge ] [ Acknowledge ] item_issues2_description: Duplicate DOI to Development of an interactive web-based tool to conduct and interrogate meta-analysis of diagnostic test accuracy studies: MetaDTA.
User Workarea, Publications Router - [ Manage ] [ Compare & Merge ] [ Acknowledge ] item_issues2_description: Duplicate Title to Development of an interactive web-based tool to conduct and interrogate meta-analysis of diagnostic test accuracy studies: MetaDTA.
User Workarea, Publications Router - [ Manage ] [ Compare & Merge ] [ Acknowledge ] item_issues2_description: Duplicate Title to Development of an interactive web-based tool to conduct and interrogate meta-analysis of diagnostic test accuracy studies: MetaDTA.
User Workarea, Publications Router - [ Manage ] [ Compare & Merge ] [ Acknowledge ] item_issues2_timestamp: 2019-06-07 09:01:35 item_issues2_timestamp: 2019-06-07 09:01:35 item_issues2_timestamp: 2019-06-07 09:01:35 item_issues2_timestamp: 2019-06-07 09:01:35 item_issues2_status: discovered item_issues2_status: discovered item_issues2_status: discovered item_issues2_status: discovered hoa_compliant: 9205 hoa_ref_pan: AB hoa_date_acc: 2019-03-31 hoa_date_pub: 2019-04-18 hoa_date_foa: 2019-12-12 hoa_version_fcd: VoR hoa_exclude: FALSE hoa_gold: TRUE oa_research_materials_ack: Yes citation: Freeman, S. C., Kerby, C. R., Patel, A., Cooper, N. J., Quinn, T. and Sutton, A. J. (2019) Development of an interactive web-based tool to conduct and interrogate meta-analysis of diagnostic test accuracy studies: MetaDTA. BMC Medical Research Methodology , 19(1), 81. (doi: 10.1186/s12874-019-0724-x ) (PMID:30999861) (PMCID:PMC6471890) document_url: https://eprints.gla.ac.uk/186839/1/article.pdf