eprintid: 160545
rev_number: 18
eprint_status: archive
userid: 37347
dir: disk0/00/16/05/45
datestamp: 2018-04-30 12:54:33
lastmod: 2021-10-06 11:01:57
status_changed: 2018-04-30 12:54:33
type: article
metadata_visibility: show
sword_depositor: 37347
creators_name: Rørth, Rasmus
creators_name: Jhund, Pardeep S.
creators_name: Mogensen, Ulrik M.
creators_name: Kristensen, Søren L.
creators_name: Petrie, Mark C.
creators_name: Køber, Lars
creators_name: McMurray, John J.V.
creators_orcid: 0000-0003-4306-5317
creators_orcid: 0000-0002-6333-9496
creators_orcid: 0000-0002-6317-3975
title: Risk of incident heart failure in patients with diabetes and asymptomatic left ventricular systolic dysfunction
ispublished: pub
divisions: 25200000
full_text_status: public
keywords: Internal medicine, endocrinology, diabetes and metabolism, advanced and specialised nursing.
abstract: Objective:
Although diabetes is well known to be common in prevalent heart failure (HF) and portends a poor prognosis, the role of diabetes in the development of incident HF is less well understood. We studied the role of diabetes in the transition from asymptomatic left ventricular systolic dysfunction (ALVSD) to overt HF in the prevention arm of the Studies of Left Ventricular Dysfunction (SOLVD-P).

Research Design and Methods:
We examined the development of symptomatic HF, HF hospitalization, and cardiovascular death according to diabetes status at baseline in patients in SOLVD-P. These outcomes were analyzed by using cumulative incidence curves and Cox regression models adjusted for age, sex, and other prognostic factors, including randomized treatment, HF severity, and comorbidity.

Results:
Of the 4,223 eligible participants, 647 (15%) had diabetes at baseline. Patients with diabetes were older and had a higher average weight, systolic blood pressure, and heart rate. During the median follow-up of 36 months, 861 of the 3,576 patients without diabetes (24%) developed HF compared with 214 of the 647 patients with diabetes (33%). In unadjusted analyses, patients with diabetes had a higher risk of development of HF (hazard ratio 1.53 [95% CI 1.32–1.78]; P <  0.001), HF hospitalization (2.04 [1.65–2.52]; P <  0.0001), and the composite outcome of development of HF or cardiovascular death (1.48 [1.30–1.69]; P < 0.001). The effect of enalapril on outcomes was not modified by diabetes status.

Conclusions:
In patients with ALVSD, diabetes is associated with an increased risk of developing HF. Development of HF is associated with an increased risk of death irrespective of diabetes status.
date: 2018-06-01
date_type: published
publication: Diabetes Care
volume: 41
number: 6
publisher: American Diabetes Association
pagerange: 1285-1291
id_number: 10.2337/dc17-2583
refereed: TRUE
issn: 0149-5992
copyright_holders: Copyright © 2018 The American Diabetes Association
prior: First published in Diabetes Care 41(6): 1285-1291
repro: Reproduced in accordance with the copyright policy of the publisher
uniqueid: glaseprints:2018-160545
issn_online: 1935-5548
pubmed_id: 29626073
euro_pubmed_id: 29626073
item_issues2_id: duplicate_doi_201428
item_issues2_id: duplicate_title_201428
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item_issues2_type: duplicate_title
item_issues2_description: Duplicate DOI to 

<a href="http://eprints.gla.ac.uk/cgi/users/home?screen=EPrint::View&amp;eprintid=201428">Risk of Incident Heart Failure in Patients With Diabetes and Asymptomatic Left Ventricular Systolic Dysfunction</a>


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<a href="http://eprints.gla.ac.uk/cgi/users/home?screen=EPrint::View&amp;eprintid=201428">Risk of Incident Heart Failure in Patients With Diabetes and Asymptomatic Left Ventricular Systolic Dysfunction</a>


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hoa_compliant: 511
hoa_emb_len: 0
hoa_ref_pan: AB
hoa_date_acc: 2018-03-17
hoa_date_pub: 2018-04-06
hoa_date_foa: 2018-04-30
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oa_research_materials_ack: Yes
citation:    Rørth, R., Jhund, P. S. <http://eprints.gla.ac.uk/view/author/10428.html>  <http://orcid.org/0000-0003-4306-5317>, Mogensen, U. M. <http://eprints.gla.ac.uk/view/author/34979.html>, Kristensen, S. L. <http://eprints.gla.ac.uk/view/author/31665.html>, Petrie, M. C. <http://eprints.gla.ac.uk/view/author/14153.html>  <http://orcid.org/0000-0002-6333-9496>, Køber, L. and McMurray, J. J.V. <http://eprints.gla.ac.uk/view/author/7025.html>  <http://orcid.org/0000-0002-6317-3975>  (2018)  Risk of incident heart failure in patients with diabetes and asymptomatic left ventricular systolic dysfunction.   Diabetes Care <https://eprints.gla.ac.uk/view/journal_volume/Diabetes_Care.html>, 41(6),  pp. 1285-1291.   (doi: 10.2337/dc17-2583 <https://doi.org/10.2337/dc17-2583>) (PMID:29626073)        
document_url: https://eprints.gla.ac.uk/160545/1/160545.pdf